Protein Alignment Cyp313a2 and CYP4A11

DIOPT Version :10

• Sequence 1: NP_650169.3
• Gene: Cyp313a2 / 41487
• FlyBaseID: FBgn0038006
• Length: 493
• Species: Drosophila melanogaster
• Sequence 2: NP_000769.2
• Gene: CYP4A11 / 1579
• HGNCID: 2642
• Length: 519
• Species: Homo sapiens
• Alignment Length: 527
• Identity: 125/527 - (23%)
• Similarity: 204/527 - (38%)
• Gaps: 78/527 - (14%)

  Fly     6 LLIAASLILWIRFLWSRRKLYM-------LMMQLPGRMGLPLLGNSVRYLIISRGRMSSRTTYMD 63
            :|.||||::.:..|....:||:       .:.|.|......|.|:             .:....|
Human    18 ILQAASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLFGH-------------IQELQQD 69

  Fly    64 KHGSTYMAWIGTTPI------------VITRDPKIAEKVL--TSPFCINRSSQTTNALALSMGYG 114
            :.......|:.|.|.            |...||...:.:|  :.|    :|..:...||..:|||
Human    70 QELQRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDP----KSHGSYRFLAPWIGYG 130

  Fly   115 LLTLQGSKWMARRKHMNPAFKHSVLLSFLPIFNAETDLLVSVFDSFVGQGEKDVLSDLIRWSFAI 179
            ||.|.|..|...|:.:.|||.:.:|..::.:......:::..::..:||       |.....|..
Human   131 LLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQ-------DSPLEVFQH 188

  Fly   180 ATQTTLGT----------DVTKDDNFENDAILKTYQSMLRLTIINIFVPFVQNKIVSKLFGL-EW 233
            .:..||.|          .:..|.|  :.:.::....:..|....:...|.||..:..|... .|
Human   189 VSLMTLDTIMKCAFSHQGSIQVDRN--SQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRW 251

  Fly   234 LRRRDASAINKMINNILDKKLNSNPENYCESELKTVIH----RAIELFRNDEMSLM---ELGAEC 291
            ..|....|.......|..:|.....|...| ::|...|    ..:.|.:.:..|::   :|.||.
Human   252 THRACQLAHQHTDQVIQLRKAQLQKEGELE-KIKRKRHLDFLDILLLAKMENGSILSDKDLRAEV 315

  Fly   292 SSMVLAAFETSAHTVYYALVLLAMFPEHQEMVFNEIKEHFPLAKGIEVTHTDLQQLVYLDRVLNE 356
            .:.:....:|:|..:.:.|..||..|:|||....||  |..|..|..:|...|.|:.|....:.|
Human   316 DTFMFEGHDTTASGISWILYALATHPKHQERCREEI--HSLLGDGASITWNHLDQMPYTTMCIKE 378

  Fly   357 TLRLMPSVPFSSRETLEDLRLSNGVVIPKGMTISIDIFNTQRNTDYWGSEAAQFNPENFLPEKIH 421
            .|||.|.||...||....:...:|..:|||:.:.:.|:....|...|.:... |:|..|.|...
Human   379 ALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEV-FDPFRFAPGSA- 441

  Fly   422 DRHPYAFIPFSKGKRNCIGWRYGLMSSKLALVKILRNYKL---KTSFPYENLEFVDHMVIKLAQS 483
             :|.:||:|||.|.|||||.::.:...|:|....|..::|   .|..|..    :..:|:|....
Human   442 -QHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIP----IARLVLKSKNG 501

  Fly   484 PQLAFER 490
            ..|...|
Human   502 IHLRLRR 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a2	NP_650169.3	CYP313-like	66..487	CDD:410680	110/455 (24%)
CYP4A11	NP_000769.2	CYP4B-like	74..505	CDD:410771	110/453 (24%)