Protein Alignment Cyp313a2 and CYP3A7

DIOPT Version :10

• Sequence 1: NP_650169.3
• Gene: Cyp313a2 / 41487
• FlyBaseID: FBgn0038006
• Length: 493
• Species: Drosophila melanogaster
• Sequence 2: NP_000756.3
• Gene: CYP3A7 / 1551
• HGNCID: 2640
• Length: 503
• Species: Homo sapiens
• Alignment Length: 522
• Identity: 134/522 - (25%)
• Similarity: 227/522 - (43%)
• Gaps: 83/522 - (15%)

  Fly     6 LLIAASLILWIRFLWSRRKLYML-MMQLPGRMGLPLLGNSVRYLIISRGRMSSRTTYMDKHGSTY 69
            ||:|.||||  .:|:..|...:. .:.:||...||.|||::.:   .:|..:.......|:...:
Human    13 LLLAVSLIL--LYLYGTRTHGLFKKLGIPGPTPLPFLGNALSF---RKGYWTFDMECYKKYRKVW 72

  Fly    70 MAWIGTTPIVITRDPKIAEKVLT----SPFCINRS----SQTTNALALSMGYGLLTLQGSKWMAR 126
            ..:....|::...||.:.:.||.    |.|...|.    ....||::::        :..:|...
Human    73 GIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISIA--------EDEEWKRI 129

  Fly   127 RKHMNPAFKHSVLLSFLPIFNAETDLLVSVFDSFVGQGEKDVLSDLI-RWSFAIATQTTLGTDVT 190
            |..::|.|....|...:||.....|:||.........|:...|..:. .:|..:.|.|:.|..:
Human   130 RSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSI- 193

  Fly   191 KDDNFEN--DAILKTYQSMLRLTIINIFV------PFVQNKIVSKLFGLEWLRRRDASAINKMIN 247
              |:..|  |..::..:.:||...::.||      ||:..  :.:...:....|:..|.:.|.:.
Human   194 --DSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTP--ILEALNITVFPRKVISFLTKSVK 254

  Fly   248 NILDKKLNS-------------NPENYCESELKTVIHRAIELFRNDEMSLMELGAECSSMVLAAF 299
            .|.:.:|..             :.:|..:||    .|:|        :|.:||.|:....:.|.:
Human   255 QIKEGRLKETQKHRVDFLQLMIDSQNSKDSE----THKA--------LSDLELMAQSIIFIFAGY 307

  Fly   300 ETSAHTVYYALVLLAMFPEHQEMVFNEIKEHFPLAKGIEVTHTDLQQLVYLDRVLNETLRLMPSV 364
            ||::..:.:.:..||..|:.|:.|..||....|  .....|:..:.||.|||.|:||||||.|..
Human   308 ETTSSVLSFIIYELATHPDVQQKVQKEIDTVLP--NKAPPTYDTVLQLEYLDMVVNETLRLFPVA 370

  Fly   365 PFSSRETLEDLRLSNGVVIPKGMTISIDIFNTQRNTDYWGSEAAQFNPENFLPEKIHDRH----- 424
            ....|...:|:.: ||:.||||:.:.|..:....:..||      ..||.||||:...::
Human   371 MRLERVCKKDVEI-NGMFIPKGVVVMIPSYVLHHDPKYW------TEPEKFLPERFSKKNKDNID 428

  Fly   425 PYAFIPFSKGKRNCIGWRYGLMSSKLALVKILRNYKLK----TSFP----YENLEFVDHMVIKLA 481
            ||.:.||..|.|||||.|:.|::.|||||::|:|:..|    |..|    :..|...:..::..|
Human   429 PYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLKA 493

  Fly   482 QS 483
            :|
Human   494 ES 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a2	NP_650169.3	CYP313-like	66..487	CDD:410680	116/461 (25%)
CYP3A7	NP_000756.3	CYP3A	67..492	CDD:410743	115/458 (25%)