DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a2 and Cyp26a1

DIOPT Version :9

Sequence 1:	NP_650169.3	Gene:	Cyp313a2 / 41487	FlyBaseID:	FBgn0038006	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_031837.2	Gene:	Cyp26a1 / 13082	MGIID:	1096359	Length:	497	Species:	Mus musculus

Alignment Length:	499	Identity:	126/499 - (25%)
Similarity:	211/499 - (42%)	Gaps:	65/499 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLIAASLILWIRFLWSRRKLYMLMMQLPGRMGLPLLGNSVRYLIISRG--RMSSRTTYMDKHGST 68
            ||..|:|.||..:..|.|.....:...||.||.|..|.:::.::..|.  :|..|     |:|..
Mouse    19 LLFLAALKLWDLYCVSSRDRSCALPLPPGTMGFPFFGETLQMVLQRRKFLQMKRR-----KYGFI 78

  Fly    69 YMAWIGTTPIVITRDPKIAEKVLTSPFCINRSSQTTNALALSMGYGLLT-LQGSKWMARRKHMNP 132
            |...:...|.|.........::|.....: .|.....::...:|.|.|: |..|....|:|.:..
Mouse    79 YKTHLFGRPTVRVMGADNVRRILLGEHRL-VSVHWPASVRTILGAGCLSNLHDSSHKQRKKVIMQ 142

  Fly   133 AFKHSVLLSFLPIFNAETDLLVSVFDSFVGQGEKDVL--SDLIRWSFAIATQTTLGTDVTKDDNF 195
            ||....|..::|:...|..   |..:.::..||:.:|  .::.|..|.||.:..||.:.......
Mouse   143 AFSREALQCYVPVIAEEVS---SCLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPGPAGGG 204

  Fly   196 END-AILKTYQSMLR-LTIINIFVPFVQNKIVSKLFGLEWLRRRDASAINKMINNILDKKLNSN- 257
            |:: .:::.::.|.| |..:.|.|||      |.|:       |...|     .|::..::..|
Mouse   205 EDEQQLVEAFEEMTRNLFSLPIDVPF------SGLY-------RGVKA-----RNLIHARIEENI 251

  Fly   258 -----------PENYCESELKTVIHRAIELFRNDEMSLMELGAECSSMVLAAFETSAHTVYYALV 311
                       |:..|:..|:.:|..:.|  |.:.:.:..|....:.::....||:|......:.
Mouse   252 RAKIRRLQATEPDGGCKDALQLLIEHSWE--RGERLDMQALKQSSTELLFGGHETTASAATSLIT 314

  Fly   312 LLAMFPEHQEMVFNEIKEHFPLAKGIEVTHTD---LQQLVYLDRVLNETLRLMPSVPFSSRETLE 373
            .|.::|...:.|..|||....|.|..:....|   |:||.|...|:.|||||.|.||...|..|:
Mouse   315 YLGLYPHVLQKVREEIKSKGLLCKSNQDNKLDMETLEQLKYTGCVIKETLRLNPPVPGGFRVALK 379

  Fly   374 DLRLSNGVVIPKGMTISIDIFNTQRNTDYWGSEAAQFNPENFLPEKIHDRHPYAFIPFSKGKRNC 438
            ...| ||..||||..:...|.:|....|.: :...:|||:.|:.....|...::||||..|.|:|
Mouse   380 TFEL-NGYQIPKGWNVIYSICDTHDVADIF-TNKEEFNPDRFIVPHPEDASRFSFIPFGGGLRSC 442

  Fly   439 IGWRYGLMSSKLALVKILRNY---------KLKTS---FPYENL 470
            :|..:..:..|:..|::.|:.         .:|||   :|.:||
Mouse   443 VGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTVYPVDNL 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a2	NP_650169.3	p450	33..463	CDD:299894	112/460 (24%)
Cyp26a1	NP_031837.2	p450	43..491	CDD:299894	118/475 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4598
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.860