DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a2 and Cyp4v3

DIOPT Version :9

Sequence 1:	NP_650169.3	Gene:	Cyp313a2 / 41487	FlyBaseID:	FBgn0038006	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_598730.1	Gene:	Cyp4v3 / 102294	MGIID:	2142763	Length:	525	Species:	Mus musculus

Alignment Length:	524	Identity:	135/524 - (25%)
Similarity:	231/524 - (44%)	Gaps:	61/524 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IQLLIAASLILWIRFLWSRRKLYMLMMQLPG-RMGLPLLGNSVRYLIISRGRMSSRTTYMD---K 64
            :.|..|..||.....|.|..:.:..|..:|. ....||:|::: |:..:......:..|..   :
Mouse    22 VSLAGATILISIFPMLVSYARKWQQMRSIPSVARAYPLVGHAL-YMKPNNAEFFQQLIYYTEEFR 85

  Fly    65 HGSTYMAWIGTTPIVITRDPKIAEKVLTSPFCINRSSQTTNALALSMGYGLLTLQGSKWMARRKH 129
            |......|||..|:|.....:..|.:|||...|::|. ....|...:|.||||..||||..|||.
Mouse    86 HLPIIKLWIGPVPLVALYKAENVEVILTSSKQIDKSF-LYKFLQPWLGLGLLTSTGSKWRTRRKM 149

  Fly   130 MNPAFKHSVLLSFLPIFNAETDLLVSVFDSFVGQGEKDVLSDLIRWSFAIATQTTLGTDVTKDDN 194
            :.|.|..::|.:||.:.|.:.::||:..:..|.|...:....:...:..|..:|.:|.::....|
Mouse   150 LTPTFHFTILENFLDVMNEQANILVNKLEKHVNQEAFNCFFYITLCALDIICETAMGKNIGAQSN 214

  Fly   195 FENDAILKTYQSMLRLTIINIFVPFVQNKIVSKLFGLEWL--------------RRRDASAINKM 245
            .:::.:...|:               .:.::.:...:.||              .:|....::..
Mouse   215 NDSEYVRTVYR---------------MSDMIYRRMKMPWLWFDLWYLVFKEGRDHKRGLKCLHTF 264

  Fly   246 INNILDKKLNSN--PENY-------CESELKTVIHRAIELFRNDE----MSLMELGAECSSMVLA 297
            .||::.:::...  .|::       ..|:.|......:.|...||    :|..::..|..:.:..
Mouse   265 TNNVIAERVKERKAEEDWTGAGRGPIPSKNKRKAFLDLLLSVTDEEGNRLSQEDIREEVDTFMFE 329

  Fly   298 AFETSAHTVYYALVLLAMFPEHQEMVFNEIKE-----HFPLAKGIEVTHTDLQQLVYLDRVLNET 357
            ..:|:|..:.::|.||...||.|..|..|:.|     |.|      ||..||::|.|||.|:.||
Mouse   330 GHDTTAAAINWSLYLLGTNPEVQRKVDQELDEVFGRSHRP------VTLEDLKKLKYLDCVIKET 388

  Fly   358 LRLMPSVPFSSRETLEDLRLSNGVVIPKGMTISIDIFNTQRNTDYWGSEAAQFNPENFLPEKIHD 422
            ||:.||||..:|...||..: .|..:.||....|..:...|:..|: .:..:|.||.|.||....
Mouse   389 LRVFPSVPLFARSLSEDCEV-GGYKVTKGTEAIIIPYALHRDPRYF-PDPEEFRPERFFPENSQG 451

  Fly   423 RHPYAFIPFSKGKRNCIGWRYGLMSSKLALVKILRNYKLKTSFPYENLEFVDHMVIKLAQSPQLA 487
            |||||::|||.|.|||||.::.:|..|..|..|||.:.::::...|.|.....::::......:.
Mouse   452 RHPYAYVPFSAGPRNCIGQKFAVMEEKTILACILRQFWVESNQKREELGLAGDLILRPNNGIWIK 516

  Fly   488 FERR 491
            .:||
Mouse   517 LKRR 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a2	NP_650169.3	p450	33..463	CDD:299894	124/465 (27%)
Cyp4v3	NP_598730.1	p450	51..517	CDD:278495	126/490 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810