Protein Alignment Cyp313a5 and CYP3A43

DIOPT Version :10

• Sequence 1: NP_650168.1
• Gene: Cyp313a5 / 41486
• FlyBaseID: FBgn0038005
• Length: 487
• Species: Drosophila melanogaster
• Sequence 2: NP_073731.1
• Gene: CYP3A43 / 64816
• HGNCID: 17450
• Length: 504
• Species: Homo sapiens
• Alignment Length: 513
• Identity: 126/513 - (24%)
• Similarity: 223/513 - (43%)
• Gaps: 84/513 - (16%)

  Fly    12 IILCVYFLWSRRRFYIMMLKLPGPMGFPFIGLAFEYIR----LKRKIRLRTILFKIYGKTVLTWI 72
            ::|.:|...|.:.|  ..|.:|||...||:|....|:|    ..|:...:      ||:....:.
Human    20 VLLYIYGTHSHKLF--KKLGIPGPTPLPFLGTILFYLRGLWNFDRECNEK------YGEMWGLYE 76

  Fly    73 GLTPVLVTCEPKILEDIFTSPNCSNRSSVVDKAISSCLGLGLLTLKNNHWNERRKLLLPSFKNNA 137
            |..|:||..:|.:::.:......|..::.:.......|...|...::..|...|.||.|:|.:..
Human    77 GQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVK 141

  Fly   138 VLSFVPVLNNEANFLV-TLLAEFVDGGDINLLPELNKWSFKIAAQITMGDEVRNQANYQNG---- 197
            ....||:::...:.|| :|..|..:...|||......::..:......|..:.:..|.|:.
Human   142 FKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKN 206

  Fly   198 -------NLLESYKALNNLIP----------IGV----VMPWLRNKY----LGKLFSYEKRRLEA 237
                   :.|:.:..|.:|.|          ||:    |..:|:|..    ..:|...:|.|::
Human   207 MKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVD- 270

  Fly   238 ATQSNAFIKDIIDKKLSSTDNSSEPALIDRILNLVRIGELSYDDVMGEFSNIIFAASDTLSITVN 302
                  |.:.:||.: :|.:..|..||.|  |.||           .:...|||||.||.|.|:.
Human   271 ------FFQQMIDSQ-NSKETKSHKALSD--LELV-----------AQSIIIIFAAYDTTSTTLP 315

  Fly   303 NVLILMAMFPKYQDNVFEELAEVFPSGGEFEASHADLEKLVKLDRVLHETMRLIPAVPLLIRQTS 367
            .::..:|..|..|..:.||:..|.|:  :...::..|.::..||.|::||:||.|.|..:.|...
Human   316 FIMYELATHPDVQQKLQEEIDAVLPN--KAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCK 378

  Fly   368 HSIQLSNGFYIPEGVTLMIDIFHTHRNKDIWGPQANAFNPDNFLPE------NKRARPPYSYLPF 426
            ..|:: ||.:||:|:.:|:.|:..|.:...|      ..|:.|.||      ||.:...|.|:||
Human   379 KDIEI-NGVFIPKGLAVMVPIYALHHDPKYW------TEPEKFCPESRFSKKNKDSIDLYRYIPF 436

  Fly   427 SKGKKTCLGWKLSLISAKLALAKILRNYMLSTTFLYKDLRF---IDNTTMKLAEQPLL 481
            ..|.:.|:|.:.:|.:.|||:.:.|:|:.....   |:.:.   :||..:...|:|::
Human   437 GAGPRNCIGMRFALTNIKLAVIRALQNFSFKPC---KETQIPLKLDNLPILQPEKPIV 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a5	NP_650168.1	CYP313-like	65..482	CDD:410680	111/456 (24%)
CYP3A43	NP_073731.1	cytochrome_P450	67..493	CDD:477761	112/464 (24%)