DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a5 and cyp4v8

DIOPT Version :9

Sequence 1:	NP_650168.1	Gene:	Cyp313a5 / 41486	FlyBaseID:	FBgn0038005	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_001071070.1	Gene:	cyp4v8 / 558851	ZFINID:	ZDB-GENE-061103-601	Length:	513	Species:	Danio rerio

Alignment Length:	515	Identity:	137/515 - (26%)
Similarity:	241/515 - (46%)	Gaps:	58/515 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 AFAIILC-VYFLWSRRRFYIMMLK----LPGPMG--FPFIGLAFEYIRLKRKIRLRTI------- 59
            |...::| .|..:...:.|:...|    :|| :|  |||||.|.:: :......|:.:
Zfish    15 ASVCVICFAYITYQLLKSYLHKWKELKPIPG-IGNTFPFIGNALQF-KSNGDFFLQLVGYTTEFQ 77

  Fly    60 ---LFKIYGKTVLTWIGLTPVLVTCEPKILEDIFTSPNCSNRSSVVDKA-----ISSCLGLGLLT 116
               |.||       |||..|.|:....:.:|.:..:|      ..:|||     :...||.||||
Zfish    78 NSPLLKI-------WIGPIPFLILFHAETVETVLNNP------VHIDKAYAYQFLHPWLGTGLLT 129

  Fly   117 LKNNHWNERRKLLLPSFKNNAVLSFVPVLNNEANFLVTLLAEFVDGGDINLLPELNKWSFKIAAQ 181
            ...:.|..|||:|.|:|..:.:..|:.|:|.:|..|:..|.:....|..|....:...:..|..:
Zfish   130 STGDKWRRRRKMLTPTFHFSILTEFLEVMNEQAEVLIEKLEKQAGKGPFNCFSHITLCALDIICE 194

  Fly   182 ITMGDEVRNQANYQNGNLLESYKALNNLIPIGVVMPWLRNKYLGKLFSYEKRRLEAATQSNAFIK 246
            ..||..:..|:||.:..:...|: ::::|.....|||....::.......:....:....::|.:
Zfish   195 TAMGKRIYAQSNYDSEYVRTVYR-MSDIITRRQRMPWYWPDFVYNYVGEGREHNRSLKILHSFTE 258

  Fly   247 DIIDKK---LSSTDNSSEP--------ALIDRILNLV-RIGE-LSYDDVMGEFSNIIFAASDTLS 298
            .:|:::   ||..::.||.        |.:|.:|... ..|: |::.|:..|....:|...||.:
Zfish   259 SVINERAEYLSYVESDSESDQGMRKRRAFLDMLLKTKDEDGKMLTHKDIQEEVDTFMFEGHDTTA 323

  Fly   299 ITVNNVLILMAMFPKYQDNVFEELAEVFPSGGEFE--ASHADLEKLVKLDRVLHETMRLIPAVPL 361
            ..:|..:.|:...|:.|....:||.|||   ||.|  .:..||:||..|:.|:.|::||.|:||.
Zfish   324 AAMNWAIHLLGSHPEVQRKAQQELFEVF---GESERPVNTEDLKKLRYLECVIKESLRLFPSVPF 385

  Fly   362 LIRQTSHSIQLSNGFYIPEGVTLMIDIFHTHRNKDIWGPQANAFNPDNFLPENKRARPPYSYLPF 426
            ..|......|: |||.:|:|..:::..:..||:...: |....|.|:.|||||...|.||:|:||
Zfish   386 FARTICDDTQI-NGFKVPKGTNIVVITYALHRDPRFF-PDPEEFRPERFLPENCVGRHPYAYIPF 448

  Fly   427 SKGKKTCLGWKLSLISAKLALAKILRNYMLSTTFLYKDLRFIDNTTMKLAEQPLLAVKRR 486
            |.|.:.|:|.:.:::..|:.||.|||.:.:......::||.:....::..:...:.::||
Zfish   449 SAGLRNCIGQRFAIMEEKVILAYILRYFNIVACQKREELRPLGELVLRPEQGIWITLERR 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a5	NP_650168.1	p450	33..458	CDD:299894	128/456 (28%)
cyp4v8	NP_001071070.1	p450	44..501	CDD:278495	130/477 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810