DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp313a5 and Cyp4d14

DIOPT Version :9

Sequence 1:	NP_650168.1	Gene:	Cyp313a5 / 41486	FlyBaseID:	FBgn0038005	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_001259179.1	Gene:	Cyp4d14 / 45706	FlyBaseID:	FBgn0023541	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	511	Identity:	133/511 - (26%)
Similarity:	228/511 - (44%)	Gaps:	56/511 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EAFAIILCVYFLWS---RRRFYIMMLK--LPGPMGFPFIGLAFEYIR--LKRKIRLRTILFKI-- 63
            |.|||:|.....|.   :||...|..:  :.||..:|.:|.|...|.  .|.|..:..:.|::
  Fly     4 ELFAILLATALAWDYMRKRRHNKMYAEAGIRGPKSYPLVGNAPLLINESPKSKSSIFDMQFRLIA 68

  Fly    64 -YGKTVLTWIGLTPVLVTCEPKILEDIFTSPNCSNRSSVVDKAISSCLGLGLLTLKNNHWNERRK 127
             :||.:.|.:......:|.:.|::|.|.:|.....::::....: :.||.|||..:...|..|||
  Fly    69 EFGKNIKTQMLGESGFMTADSKMIEAIMSSQQTIQKNNLYSLLV-NWLGDGLLISQGKKWFRRRK 132

  Fly   128 LLLPSFKNNAVLSFVPVLNNEANFLVTLLAEFVDGGD-INLLPELNKWSFKIAAQITMGDEVRNQ 191
            ::.|:|....:..||.|.:.::..:|..|.:..||.. ||:.|.....:..|.|:..||.::..|
  Fly   133 IITPAFHFKILEDFVEVFDQQSATMVQKLYDRADGKTVINMFPVACLCAMDIIAETAMGVKINAQ 197

  Fly   192 ANYQNGNLLESYKALNNLIPIGVVMPWLRNKYLGKLFSYEK---RRLEAATQSNAFIKDIIDKK- 252
            ...| ...::|....:.::....:.|..|..:..||| |.|   :..:|....:.|...:|.::
  Fly   198 LQPQ-FTYVQSVTTASAMLAERFMNPLQRLDFTMKLF-YPKLLDKLNDAVKNMHDFTNSVITERR 260

  Fly   253 -----------------LSSTDNSSEPALIDRILNLVRIG-ELSYDDVMGEFSNIIFAASDTLSI 299
                             |:........||:|.:|.....| .||.||:..|....:|...||.:.
  Fly   261 ELLQKAIADGGDADAALLNDVGQKRRMALLDVLLKSTIDGAPLSNDDIREEVDTFMFEGHDTTTS 325

  Fly   300 TVNNVLILMAMFPKYQDNVFEELAEVFPSGGEFEASHADLEKLVKLDRVLHETMRLIPAVPLLIR 364
            ::.....|:|..|:.|..||:|:.:|.........:...|.:|..|:.|:.|::||.|:||::.|
  Fly   326 SIAFTCYLLARHPEVQARVFQEVRDVIGDDKSAPVTMKLLGELKYLECVIKESLRLFPSVPIIGR 390

  Fly   365 QTSHSIQLSNGFYIPEGVTLMIDIFHTHRNKDIWGPQANAFNPDNFLPENKRARPPYSYLPFSKG 429
            ..|....| :|..||....::|.|:|..|:.|.: |....|.||.|..|.|....|::|.|||.|
  Fly   391 YISQDTVL-DGKLIPADSNVIILIYHAQRDPDYF-PDPEKFIPDRFSMERKGEISPFAYTPFSAG 453

  Fly   430 KKTCLGWKLSLISAKLALAKILRNYMLSTTFLYKDLRFIDNTTMKLAE--QPLLAV 483
            .:.|:|.|.:::..|..::|::|::.|                :.|.|  ||:|.|
  Fly   454 PRNCIGQKFAMLEMKSTISKMVRHFEL----------------LPLGEEVQPVLNV 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a5	NP_650168.1	p450	33..458	CDD:299894	118/452 (26%)
Cyp4d14	NP_001259179.1	p450	34..489	CDD:278495	120/475 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.860