DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a5 and cyp46a1.4

DIOPT Version :9

Sequence 1:	NP_650168.1	Gene:	Cyp313a5 / 41486	FlyBaseID:	FBgn0038005	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	XP_005160404.1	Gene:	cyp46a1.4 / 393451	ZFINID:	ZDB-GENE-040426-1224	Length:	501	Species:	Danio rerio

Alignment Length:	510	Identity:	106/510 - (20%)
Similarity:	207/510 - (40%)	Gaps:	94/510 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IFEAFAIILCVYFLWSRRRFYIMMLKLPGPMGFPFIGLAFEYIRLKRKIRLR--TILFKIYGKTV 68
            :|.|| :..|:|..:..:::.    .:|||   |.....|.:.....|....  :::..::
Zfish    17 VFTAF-LAYCLYIHYVHQKYD----HIPGP---PRDNFLFGHSPSLTKSMYADDSLIHDLF---- 69

  Fly    69 LTW------------IGLTPVLVTCEPKILEDIFTSPNCSNRSSVVDKAIS----SCLGLGLLT- 116
            |.|            :....::|.| |:..:.|..||..:....|..:..:    ..||.||:|
Zfish    70 LQWAEKYGPVYRINSLHYIAIVVHC-PEATKTILMSPKYTKDPFVYRRLFNLFGKRFLGYGLITA 133

  Fly   117 LKNNHWNERRKLLLPSFKNNAVLSFVPVLNNEANFLVTLLAEFVDGGDINLLPEL-NKWSFKIAA 180
            :.::.|..:|:::.|:|.::.:.|.:...:..:..|:..|.|..:.....::.:| |..:..:..
Zfish   134 VDHDIWYRQRRIMDPAFSSSYLRSLISTFDEMSERLMDKLEEMANNKTPAVMHDLVNCVTLDVIC 198

  Fly   181 QITMGDEV----RNQANYQNGNLL------------------ESYKALNNLIPIGVVM-----PW 218
            ::..|.::    :..:.:||...|                  :::|.::.:.....::     .|
Zfish   199 KVAFGVDLNFLAQKDSPFQNAVELCLNGMTVDLRDPFFRLFPKNWKLIHQIRDAAELLRKTGEKW 263

  Fly   219 LRNKYLGKLFSYEKRRLEAATQSNAFIKDIIDKKLSSTDNSSEPALIDRILNLVRIGELSYDDVM 283
            ::|            |..|........|||:.:.|.|.:..          |:....:|  :.::
Zfish   264 IQN------------RKTAVKNGEDVPKDILTQILKSAEEE----------NVNNTDDL--EQML 304

  Fly   284 GEFSNIIFAASDTLSITVNNVLILMAMFPKYQDNVFEELAEVFPSGGEFEASHADLEKLVKLDRV 348
            ..|.....|..:|.:..::..::.:...|:.......|:.||.  |.:.|.|:.||.|...|.:|
Zfish   305 DNFVTFFIAGQETTANQLSFAIMALGRNPEIYKRAKAEVDEVL--GTKREISNEDLGKFTYLSQV 367

  Fly   349 LHETMRLIPAVPLLIRQTSHSIQLSNGFYIPEGVTLMIDIFHTHRNKDIWGPQANAFNPDNFLPE 413
            |.||:||.|..|...|.. |...:.||..||.|.::|...:.:.|.:..:..... |:|:.|  :
Zfish   368 LKETLRLYPTAPGTNRWL-HEDMVINGIKIPGGCSVMFSSYVSQRLEKFFKDPLK-FDPERF--D 428

  Fly   414 NKRARPPYSYLPFSKGKKTCLGWKLSLISAKLALAKILRNYMLS----TTFLYKD 464
            ....:|.|.|.||:.|.:||||...|.:.||:.|||:|:.:..|    .:|..||
Zfish   429 VNAPKPYYCYFPFALGPRTCLGQVFSQMEAKVVLAKLLQRFEFSLVPGQSFDIKD 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a5	NP_650168.1	p450	33..458	CDD:299894	98/475 (21%)
cyp46a1.4	XP_005160404.1	p450	39..495	CDD:278495	101/483 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D825914at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010