Protein Alignment Cyp313a5 and CYP4A22

DIOPT Version :9

• Sequence 1: NP_650168.1
• Gene: Cyp313a5 / 41486
• FlyBaseID: FBgn0038005
• Length: 487
• Species: Drosophila melanogaster
• Sequence 2: NP_001010969.2
• Gene: CYP4A22 / 284541
• HGNCID: 20575
• Length: 519
• Species: Homo sapiens
• Alignment Length: 482
• Identity: 107/482 - (22%)
• Similarity: 206/482 - (42%)
• Gaps: 50/482 - (10%)

  Fly     6 IFEAFAIILCVYFLWSRRRFYI---MMLK----LPGPMGFPFIG--LAFEYIRLKRKIRLRTILF 61
            |.:..::::.:..|....:.|:   .:||    .|.|......|  ..|::.:..::|:.|.
Human    18 ILQVTSLLILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLFGHIQEFQHDQELQRIQERV--- 79

  Fly    62 KIYGKTVLTWIGLTPVLVTC-EPKILEDIFTSPNCSNRSSVVDKAISSCLGLGLLTLKNNHWNER 125
            |.:......||....|.|.. :|..::.|....:..:..|.  |.::..:|.|||.|....|.:.
Human    80 KTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGSY--KFLAPRIGYGLLLLNGQTWFQH 142

  Fly   126 RKLLLPSFKNNAVLSFVPVLNNEANFLVTLLAEFVDGGDINL----------LPELNKWSFKIAA 180
            |::|.|:|.|:.:..:|.::.:....::....|.: |.|..|          |..:.|.:|....
Human   143 RRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELL-GQDSPLEVFQHVSLMTLDTIMKSAFSHQG 206

  Fly   181 QITMGDEVRNQANYQNGNLLESYKALNNLIPIGVVMPWLRNKYLGKLFSYEKRRLEAATQSNAFI 245
            .|.:.   ||..:|     :::...||:|:...:...:..|..:..|.|..:....|...::...
Human   207 SIQVD---RNSQSY-----IQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHT 263

  Fly   246 KDIIDKKLSSTDNSSEPALIDR--------ILNLVRIGE---LSYDDVMGEFSNIIFAASDTLSI 299
            ..:|..:.:......|...|.|        ||.|.::..   ||..|:..|....:|...||.:.
Human   264 DQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTAS 328

  Fly   300 TVNNVLILMAMFPKYQDNVFEELAEVFPSGGEFEASHADLEKLVKLDRVLHETMRLIPAVPLLIR 364
            .::.:|..:|..||:|:...||:..:...|.....:|  |:::......:.|.:||.|.||.:.|
Human   329 GISWILYALATHPKHQERCREEIHGLLGDGASITWNH--LDQMPYTTMCIKEALRLYPPVPGIGR 391

  Fly   365 QTSHSIQLSNGFYIPEGVTLMIDIFHTHRNKDIWGPQANAFNPDNFLPENKRARPPYSYLPFSKG 429
            :.|..:...:|..:|:|:.:::.|:..|.|..:| |....|:|..|.|.:  |:..:::||||.|
Human   392 ELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVW-PNLEVFDPSRFAPGS--AQHSHAFLPFSGG 453

  Fly   430 KKTCLGWKLSLISAKLALAKILRNYML 456
            .:.|:|.:.::...|:|.|..|..:.|
Human   454 SRNCIGKQFAMNQLKVARALTLLRFEL 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a5	NP_650168.1	p450	33..458	CDD:299894	102/448 (23%)
CYP4A22	NP_001010969.2	p450	52..505	CDD:278495	102/448 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D825914at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820