Protein Alignment Cyp313a5 and CYP4X1

DIOPT Version :10

• Sequence 1: NP_650168.1
• Gene: Cyp313a5 / 41486
• FlyBaseID: FBgn0038005
• Length: 487
• Species: Drosophila melanogaster
• Sequence 2: NP_828847.1
• Gene: CYP4X1 / 260293
• HGNCID: 20244
• Length: 509
• Species: Homo sapiens
• Alignment Length: 492
• Identity: 118/492 - (23%)
• Similarity: 202/492 - (41%)
• Gaps: 71/492 - (14%)

  Fly     2 LTLQIFEAFAIILCVYFLWSRRRFYIMMLKLPGPMGFPFIGLAFEYIRLKRKIRLRTILFKIYGK 66
            |.|.:.:|..:.|      .|:|....:...|.|....|:|.. ::|:.....:|..|:.| |.:
Human    22 LALGLLQAIKLYL------RRQRLLRDLRPFPAPPTHWFLGHQ-KFIQDDNMEKLEEIIEK-YPR 78

  Fly    67 TVLTWIG-LTPVLVTCEPKILEDIF--TSPNCSNRSSVVDKAISSCLGLGLLTLKNNHWNERRKL 128
            ....||| ........:|...:.:.  |.|    :|..:.|.....||.||..|....|.:.|:|
Human    79 AFPFWIGPFQAFFCIYDPDYAKTLLSRTDP----KSQYLQKFSPPLLGKGLAALDGPKWFQHRRL 139

  Fly   129 LLPSFKNNAVLSFVPVLNNEANFLVTLLAEFVDGGD--INLLPELNKWSFKIAAQITMGDEVRNQ 191
            |.|.|..|.:.:::.|:.:....::....:.....|  :.:...:|..|..|..:.....|...|
Human   140 LTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETNCQ 204

  Fly   192 ANYQNGNLLESYKALNNLI------------------PIGVVMPWLR---NKYLGKLFSYEKRRL 235
            .|..:....::...|:.:|                  |.|.....|.   |:|...:....|:.|
Human   205 TNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSL 269

  Fly   236 EAATQSNAFIK----DIIDKKLSSTDNSSEPALIDRILNLVRIGELSYDDVMGEFSNIIFAASDT 296
            :|..:.:...|    |.:|..||:.|.|.              ...|..||..|.|..:.|..||
Human   270 QAGVKQDNTPKRKYQDFLDIVLSAKDESG--------------SSFSDIDVHSEVSTFLLAGHDT 320

  Fly   297 LSITVNNVLILMAMFPKYQDNVFEELAEVFPSGGEF------EASHADLEKLVKLDRVLHETMRL 355
            |:.:::.:|..:|:.|::|:...||:..:...|...      |.|:..:        .:.||.||
Human   321 LAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQLGEMSYTTM--------CIKETCRL 377

  Fly   356 IPAVPLLIRQTSHSIQLSNGFYIPEGVTLMIDIFHTHRNKDIWGPQANAFNPDNFLPENKRARPP 420
            |||||.:.|..|..:...:|..:|.|:|:::.|:..|.|..:| .....|:|..|..||...|.|
Human   378 IPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVW-KNPKVFDPLRFSQENSDQRHP 441

  Fly   421 YSYLPFSKGKKTCLGWKLSLISAKLALAKILRNYMLS 457
            |:|||||.|.:.|:|.:.::|..|:.:|.||.::.::
Human   442 YAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVT 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a5	NP_650168.1	CYP313-like	65..482	CDD:410680	103/429 (24%)
CYP4X1	NP_828847.1	CYP4B-like	66..502	CDD:410771	107/441 (24%)
		heme binding region	447..460		5/12 (42%)