Protein Alignment Cyp313a5 and CYP26A1

DIOPT Version :10

• Sequence 1: NP_650168.1
• Gene: Cyp313a5 / 41486
• FlyBaseID: FBgn0038005
• Length: 487
• Species: Drosophila melanogaster
• Sequence 2: NP_000774.2
• Gene: CYP26A1 / 1592
• HGNCID: 2603
• Length: 497
• Species: Homo sapiens
• Alignment Length: 480
• Identity: 114/480 - (23%)
• Similarity: 223/480 - (46%)
• Gaps: 59/480 - (12%)

  Fly     1 MLTLQIFEAFAIILCVYFLWSRRRFYIMMLKLPGPMGFPFIGLAFEYIRLKRKI-----RLRTIL 60
            :|.|.:|.|...:..:|.:..|.|...:.|. ||.|||||.|...:.:..:||.     |....:
Human    15 VLPLLLFLAAIKLWDLYCVSGRDRSCALPLP-PGTMGFPFFGETLQMVLQRRKFLQMKRRKYGFI 78

  Fly    61 FK--IYGKTVLTWIGLTPV--LVTCEPKILEDIFTSPNCSNRSSVVDKAISSCLGLGLLT-LKNN 120
            :|  ::|:..:..:|...|  ::..|.:::...:.:            ::.:.||.|.|: |.::
Human    79 YKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPA------------SVRTILGSGCLSNLHDS 131

  Fly   121 HWNERRKLLLPSFKNNAVLSFVPVLNNEANFLVTLLAEFVDGGDINLL--PELNKWSFKIAAQIT 183
            ...:|:|:::.:|...|:..:|||:..|..   :.|.:::..|:..||  ||:.:..|:||.:|.
Human   132 SHKQRKKVIMRAFSREALECYVPVITEEVG---SSLEQWLSCGERGLLVYPEVKRLMFRIAMRIL 193

  Fly   184 MGDEVRNQANYQN-GNLLESYKAL-NNLIPIGVVMPWLRNKYLGKLFSYEKRRLEAATQSNAFIK 246
            :|.|.:...:..: ..|:|:::.: .||..:.:.:|          ||...|.::|....:|.|:
Human   194 LGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVP----------FSGLYRGMKARNLIHARIE 248

  Fly   247 DIIDKKL-----SSTDNSSEPALIDRILNLVRIGE-LSYDDVMGEFSNIIFAASDTLSITVNNVL 305
            ..|..|:     |......:.||...|.:....|| |....:....:.::|...:|.:....:::
Human   249 QNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLI 313

  Fly   306 ILMAMFPKYQDNVFEELAEVFPSGGEFEASHAD-------LEKLVKLDRVLHETMRLIPAVPLLI 363
            ..:.::|    :|.:::.|...|.|....|:.|       ||:|..:..|:.||:||.|.||...
Human   314 TYLGLYP----HVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGF 374

  Fly   364 RQTSHSIQLSNGFYIPEGVTLMIDIFHTHRNKDIWGPQANAFNPDNFLPENKRARPPYSYLPFSK 428
            |....:.:| ||:.||:|..::..|..||...:|: .....||||.|:..:......:|::||..
Human   375 RVALKTFEL-NGYQIPKGWNVIYSICDTHDVAEIF-TNKEEFNPDRFMLPHPEDASRFSFIPFGG 437

  Fly   429 GKKTCLGWKLSLISAKLALAKILRN 453
            |.::|:|.:.:.|..|:...::.|:
Human   438 GLRSCVGKEFAKILLKIFTVELARH 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a5	NP_650168.1	CYP313-like	65..482	CDD:410680	94/409 (23%)
CYP26A1	NP_000774.2	CYP26A1	55..490	CDD:410731	99/439 (23%)