DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a5 and Cyp4b1

DIOPT Version :9

Sequence 1:	NP_650168.1	Gene:	Cyp313a5 / 41486	FlyBaseID:	FBgn0038005	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_031849.1	Gene:	Cyp4b1 / 13120	MGIID:	103225	Length:	511	Species:	Mus musculus

Alignment Length:	501	Identity:	116/501 - (23%)
Similarity:	200/501 - (39%)	Gaps:	92/501 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 AFAIILCV------YFLWSRRRFYIMMLKLPGPMGFPFIGLAFEYIRLKRKIRLRTILFKIYG-K 66
            |..:||.|      ..|:.|::....:...|||......|.|.|             :.|..| .
Mouse    17 ASVVILMVTVLKLLSLLFRRQKLARALDSFPGPPKHWLFGHALE-------------IQKTGGLD 68

  Fly    67 TVLTWIGLTP------------VLVTCEPKILEDIFTSPNCSNRSSVVDKAISSCLGLGLLTLKN 119
            .|:||....|            .|...||...:.:::..:  .:::.|.......:|.|||.|:.
Mouse    69 KVVTWTEQFPYAHPLWLGQFIVFLNIYEPDYAKAVYSRGD--PKAAYVYDFFLQWIGKGLLVLEG 131

  Fly   120 NHWNERRKLLLPSFKNNAVLSFVPVLNNEANFLVTLLAEFVDGGDINLLPELNKW--------SF 176
            ..|.:.||||.|.|..:.:..:|.:.......:                  |:||        ||
Mouse   132 PKWFQHRKLLTPGFHYDVLKPYVAIFAESTRVM------------------LDKWEKKASENKSF 178

  Fly   177 KIAAQI-TMGDEVRNQANYQNGN--LLES----YKALNNLIPIGVVMP------WLRNKYLGKLF 228
            .|...: .|..:...:..:..|:  |..|    |.|:::|.   ::|.      ...|.::..|.
Mouse   179 DIFCDVGHMALDTLMKCTFGKGDSGLSHSDNSYYLAVSDLT---LLMQQRIDSFQYHNDFIYWLT 240

  Fly   229 SYEKRRLEAATQSNAFIKDII-DKKLSSTDNSSEPALIDR----ILNLVRIG-------ELSYDD 281
            .:.:|.|.|...::.....:| .:|.:..|...:..|.:|    .|::: :|       :||..|
Mouse   241 PHGRRFLRACQIAHDHTDHVIRQRKAALQDEKEQKKLQERRHLDFLDIL-LGARDESGIKLSDAD 304

  Fly   282 VMGEFSNIIFAASDTLSITVNNVLILMAMFPKYQDNVFEELAEVFPSGGEFEASHADLEKLVKLD 346
            :..|....:|...||.:..::..|..||::|.:|....||:.|:......|:..  ||.::..|.
Mouse   305 LRAEVDTFMFEGHDTTTSGISWFLYCMALYPMHQQRCREEVREILGDRDSFQWD--DLAQMTYLT 367

  Fly   347 RVLHETMRLIPAVPLLIRQTSHSIQLSNGFYIPEGVTLMIDIFHTHRNKDIWGPQANAFNPDNFL 411
            ..:.|..||.|.||.:.||.|..:...:|..:|.|..:.:.|:..|||..:| |....|:|..|.
Mouse   368 MCMKECFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISLHIYALHRNSAVW-PDPEVFDPLRFS 431

  Fly   412 PENKRARPPYSYLPFSKGKKTCLGWKLSLISAKLALAKILRNYMLS 457
            |||...|.|::::|||.|.:.|:|.:.::...|:..|..|..:..|
Mouse   432 PENMTGRHPFAFMPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFS 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a5	NP_650168.1	p450	33..458	CDD:299894	110/471 (23%)
Cyp4b1	NP_031849.1	p450	47..500	CDD:278495	110/471 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810