DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a5 and Cyp4a10

DIOPT Version :9

Sequence 1:	NP_650168.1	Gene:	Cyp313a5 / 41486	FlyBaseID:	FBgn0038005	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_034141.3	Gene:	Cyp4a10 / 13117	MGIID:	88611	Length:	509	Species:	Mus musculus

Alignment Length:	494	Identity:	112/494 - (22%)
Similarity:	201/494 - (40%)	Gaps:	74/494 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LQIFEAFAIIL----CVYFLWSRRRFYIMMLKLPGPMGFPFIGLAFEYIRLKRKIRLRTILFKI- 63
            ||:.....::|    .|.|...|:.......:.|.|   ||... |.:.:.|....|:.|:..|
Mouse    19 LQVASVLGLLLLLVKAVQFYLHRQWLLKAFQQFPSP---PFHWF-FGHEKFKGDQELQEIVSCIE 79

  Fly    64 -YGKTVLTWI-GLTPVLVTCEPKILEDIF--TSPNCSNRSSVVDKAISSCLGLGLLTLKNNHWNE 124
             :......|. |....|...:|..::.|.  :.|    :::...:.::..:|.|||.|....|.:
Mouse    80 NFPSAFPRWFWGSKAYLTVYDPDYMKVILGRSDP----KANGAYRLLAPWIGYGLLLLNGQPWFQ 140

  Fly   125 RRKLLLPSFKNNAVLSFVPVLNNEANFLVTLLAEFVDGGDINLLPELNKW--------SFKIAAQ 181
            .|::|.|:|..:.:   .|.:.|.|:             .|.|:  |:||        |.:|...
Mouse   141 HRRMLTPAFHYDIL---KPYVKNMAD-------------SIRLM--LDKWERLADQDSSIEIFQH 187

  Fly   182 ITM-------------GDEVRNQANYQNGNLLESYKALNNLIPIGVVMPWLRNKYLGKLFSYEKR 233
            |::             ...|:...||:  ..|::...||||....|...:.:|..:.||.|..:.
Mouse   188 ISLMTLDTVMKCAFSHKGSVQVDGNYR--TYLQAIGDLNNLFHSRVRNIFHQNDTIYKLSSNGRL 250

  Fly   234 RLEAATQSNAFIKDIIDKKLSSTDNSSEPALIDR--------ILNLVRI---GELSYDDVMGEFS 287
            ..:|...::.....:|..:.....:..|...|.:        ||...|:   ..:|..|:..|..
Mouse   251 AKQACQLAHDHTDGVIKLRKDQLQDEGELEKIKKKRRLDFLDILLFARMENGDSMSDKDLRAEVD 315

  Fly   288 NIIFAASDTLSITVNNVLILMAMFPKYQDNVFEELAEVFPSGGEFEASHADLEKLVKLDRVLHET 352
            ..:|...||.:..|:.:...:|..|.:|....||:..:...|......|  |:::......:.|.
Mouse   316 TFMFEGHDTTASGVSWIFYALATHPDHQQRCREEVQSLLGDGSSITWDH--LDQIPYTTMCIKEA 378

  Fly   353 MRLIPAVPLLIRQTSHSIQLSNGFYIPEGVTLMIDIFHTHRNKDIWGPQANAFNPDNFLPENKRA 417
            :||.|.||.::|:.|.|:...:|..:|:||.:.:.|:..|.|..:| |....|:|..|.|::  .
Mouse   379 LRLYPPVPGIVRELSTSVTFPDGRSLPKGVQVTLSIYGLHHNPKVW-PNPEVFDPSRFAPDS--P 440

  Fly   418 RPPYSYLPFSKGKKTCLGWKLSLISAKLALAKILRNYML 456
            |..:|:||||.|.:.|:|.:.::...|:.:|..|..:.|
Mouse   441 RHSHSFLPFSGGARNCIGKQFAMSELKVIVALTLLRFEL 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a5	NP_650168.1	p450	33..458	CDD:299894	106/461 (23%)
Cyp4a10	NP_034141.3	p450	52..503	CDD:278495	106/461 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810