DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp313a5 and Cyp46a1

DIOPT Version :9

Sequence 1:	NP_650168.1	Gene:	Cyp313a5 / 41486	FlyBaseID:	FBgn0038005	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_034140.1	Gene:	Cyp46a1 / 13116	MGIID:	1341877	Length:	500	Species:	Mus musculus

Alignment Length:	508	Identity:	114/508 - (22%)
Similarity:	212/508 - (41%)	Gaps:	65/508 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLTLQIFEAFAIILCVYFLWSRRRFYIMMLKLPGPMGFPFIGLAFEYIRLKRKI--RLRTILF-- 61
            :|...:..||.  ||..|:...|..|   ..:|||....|:.....|...|.:.  |:...:|
Mouse     7 LLGSAVLLAFG--LCCTFVHRARSRY---EHIPGPPRPSFLLGHLPYFWKKDEDCGRVLQDVFLD 66

  Fly    62 --KIYGKTVLTWIGLTPVLVTCEPKILEDIFTSPNCSNRSSVVDKAISS-----CLGLGLLT-LK 118
              |.||..|...:.....::...|:.::....|.. .|:.|.:.:|:.:     ..|.||:: ..
Mouse    67 WAKKYGPVVRVNVFYKTSVIVTSPESVKKFLMSTK-YNKDSKMYRALQTVFGERLFGQGLVSECD 130

  Fly   119 NNHWNERRKLLLPSFKNNAVLSFVPVLNNEANFLVTLLAEFVDG-GDINLLPELNKWSFKIAAQI 182
            ...|.::||::..:|..::::|.:...|.:|..||.:|....|| ..:::...|...:..|.|:.
Mouse   131 YGRWYKQRKVMDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTCATIDILAKA 195

  Fly   183 TMGDEVRNQANYQNGNLLESYKALNNLIPI---GVVMPWLRNKYLGKLFSYEKRRLEAATQSNAF 244
            ..|.|        ...||.:.|.|:..:.:   |:...  ||. |.|....::::|....:|...
Mouse   196 AFGME--------TSMLLGAQKPLSQAVKVMLEGISAS--RNT-LAKFMPGKRKQLREIRESIRL 249

  Fly   245 I----KDIIDKKLSSTDNSSE-PALIDRILNLVRIGELSYDD--VMGEFSNIIFAASDTLSITVN 302
            :    ||.:.::..:.....: ||  |.:..:::..|.:.||  ::..|.....|..:|.:..:.
Mouse   250 LRQVGKDWVQRRREALKRGEDMPA--DILTQILKAEEGAQDDEVLLDNFVTFFIAGHETSANHLA 312

  Fly   303 NVLILMAMFPKYQDNVFEELAEVFPSGGEFEASHADLEKLVKLDRVLHETMRLIP----AVPLLI 363
            ..::.::..|:....:..|:.||.  |.:....:.||.:|..|.:||.|::||.|    ...||.
Mouse   313 FTVMELSRQPEIVARLQAEVDEVV--GSKRHLDYEDLGRLQYLSQVLKESLRLYPPAWGTFRLLE 375

  Fly   364 RQTSHSIQLSNGFYIPEGVTLMIDIFHTHRNKDIWGPQANAFNPDNFLPENKRARPPYSYLPFSK 428
            .:|     |.:|..:|....|:...:...| .|.:......||||.|.|  ...:|.::|.|||.
Mouse   376 EET-----LIDGVRVPGNTPLLFSTYVMGR-MDTYFEDPLTFNPDRFGP--GAPKPRFTYFPFSL 432

  Fly   429 GKKTCLGWKLSLISAKLALAKILRNYMLSTTFLYKDLRFIDNTTMKLAEQPLL 481
            |.::|:|.:.:.:..|:.:||:|:..         :.|.:......|.||..|
Mouse   433 GHRSCIGQQFAQMEVKVVMAKLLQRI---------EFRLVPGQRFGLQEQATL 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a5	NP_650168.1	p450	33..458	CDD:299894	101/451 (22%)
Cyp46a1	NP_034140.1	p450	34..466	CDD:278495	102/464 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D825914at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010