Protein Alignment Cyp313a5 and CYP46A1

DIOPT Version :10

• Sequence 1: NP_650168.1
• Gene: Cyp313a5 / 41486
• FlyBaseID: FBgn0038005
• Length: 487
• Species: Drosophila melanogaster
• Sequence 2: NP_006659.1
• Gene: CYP46A1 / 10858
• HGNCID: 2641
• Length: 500
• Species: Homo sapiens
• Alignment Length: 511
• Identity: 120/511 - (23%)
• Similarity: 219/511 - (42%)
• Gaps: 71/511 - (13%)

  Fly     1 MLTLQIFEAFAIILCVYFLWSRRRFYIMMLKLPGPMGFPFIGLAFEYIRLKRKIRLRTI--LF-- 61
            :|...:..||.  ||..|:...|..|   ..:|||....|:.........|.::..|.:  :|
Human     7 LLGSAVLLAFG--LCCTFVHRARSRY---EHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLD 66

  Fly    62 --KIYGKTV-LTWIGLTPVLVTCEPKILEDIFTSPNCSNRSSVVDKAISS-----CLGLGLLTLK 118
              |.||..| :.....|.|:|| .|:.::....|.. .|:.|.:.:|:.:     ..|.||::..
Human    67 WAKKYGPVVRVNVFHKTSVIVT-SPESVKKFLMSTK-YNKDSKMYRALQTVFGERLFGQGLVSEC 129

  Fly   119 N-NHWNERRKLLLPSFKNNAVLSFVPVLNNEANFLVTLLAEFVDG-GDINLLPELNKWSFKIAAQ 181
            | ..|:::|:::..:|..::::|.:...|.:|..||.:|....|| ..:::...|...:..|.|:
Human   130 NYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAK 194

  Fly   182 ITMGDEVRNQANYQNGNLLESYKALNNLIPI---GVVMPWLRNKYLGKLFSYEKRRLEAATQSNA 243
            ...|.|        ...||.:.|.|:..:.:   |:...  ||. |.|....::::|....:|..
Human   195 AAFGME--------TSMLLGAQKPLSQAVKLMLEGITAS--RNT-LAKFLPGKRKQLREVRESIR 248

  Fly   244 FI----KDIIDKKLSSTDNSSE-PALIDRILNLVRIGELSYDD--VMGEFSNIIFAASDTLSITV 301
            |:    :|.:.::..:.....| ||  |.:..:::..|.:.||  ::..|.....|..:|.:..:
Human   249 FLRQVGRDWVQRRREALKRGEEVPA--DILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHL 311

  Fly   302 NNVLILMAMFPKYQDNVFEELAEVFPSGG--EFEASHADLEKLVKLDRVLHETMRLIP----AVP 360
            ...::.::..|:....:..|:.||..|..  :||    ||.:|..|.:||.|::||.|    ...
Human   312 AFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFE----DLGRLQYLSQVLKESLRLYPPAWGTFR 372

  Fly   361 LLIRQTSHSIQLSNGFYIPEGVTLMIDIFHTHRNKDIWGPQANAFNPDNFLPENKRARPPYSYLP 425
            ||..:|     |.:|..:|....|:...:...| .|.:......||||.|.|  ...:|.::|.|
Human   373 LLEEET-----LIDGVRVPGNTPLLFSTYVMGR-MDTYFEDPLTFNPDRFGP--GAPKPRFTYFP 429

  Fly   426 FSKGKKTCLGWKLSLISAKLALAKILRNYMLSTTFLYKDLRFIDNTTMKLAEQPLL 481
            ||.|.::|:|.:.:.:..|:.:||:|:..         :.|.:......|.||..|
Human   430 FSLGHRSCIGQQFAQMEVKVVMAKLLQRL---------EFRLVPGQRFGLQEQATL 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a5	NP_650168.1	CYP313-like	65..482	CDD:410680	103/441 (23%)
CYP46A1	NP_006659.1	CYP46A1-like	61..484	CDD:410706	106/452 (23%)