DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a5 and Cyp4v3

DIOPT Version :9

Sequence 1:	NP_650168.1	Gene:	Cyp313a5 / 41486	FlyBaseID:	FBgn0038005	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_598730.1	Gene:	Cyp4v3 / 102294	MGIID:	2142763	Length:	525	Species:	Mus musculus

Alignment Length:	514	Identity:	141/514 - (27%)
Similarity:	238/514 - (46%)	Gaps:	54/514 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 AFAIILCVYF--LWSRRRFYIMMLKLPG-PMGFPFIGLAFEYIRLKRKIRLRTILFKIYGK---- 66
            |.|.||...|  |.|..|.:..|..:|. ...:|.:|.|. |::.......:.:::  |.:
Mouse    25 AGATILISIFPMLVSYARKWQQMRSIPSVARAYPLVGHAL-YMKPNNAEFFQQLIY--YTEEFRH 86

  Fly    67 --TVLTWIGLTPVLVTCEPKILEDIFTSPNCSNRSSVVDKA-----ISSCLGLGLLTLKNNHWNE 124
              .:..|||..|::...:.:.:|.|.||      |..:||:     :...|||||||...:.|..
Mouse    87 LPIIKLWIGPVPLVALYKAENVEVILTS------SKQIDKSFLYKFLQPWLGLGLLTSTGSKWRT 145

  Fly   125 RRKLLLPSFKNNAVLSFVPVLNNEANFLVTLLAEFVDGGDINLLPELNKWSFKIAAQITMGDEVR 189
            |||:|.|:|....:.:|:.|:|.:||.||..|.:.|:....|....:...:..|..:..||..:.
Mouse   146 RRKMLTPTFHFTILENFLDVMNEQANILVNKLEKHVNQEAFNCFFYITLCALDIICETAMGKNIG 210

  Fly   190 NQANYQNGNLLESYKALNNLIPIGVVMPWLRNKYLGKLFSY---EKRRLEAA-TQSNAFIKDIID 250
            .|:|..:..:...|: ::::|...:.||||.......:|..   .||.|:.. |.:|..|.:.:.
Mouse   211 AQSNNDSEYVRTVYR-MSDMIYRRMKMPWLWFDLWYLVFKEGRDHKRGLKCLHTFTNNVIAERVK 274

  Fly   251 KKLSSTD-----------NSSEPALIDRILNLV--RIGELSYDDVMGEFSNIIFAASDTLSITVN 302
            ::.:..|           .:...|.:|.:|::.  ....||.:|:..|....:|...||.:..:|
Mouse   275 ERKAEEDWTGAGRGPIPSKNKRKAFLDLLLSVTDEEGNRLSQEDIREEVDTFMFEGHDTTAAAIN 339

  Fly   303 NVLILMAMFPKYQDNVFEELAEVFPSGGEFEASH-----ADLEKLVKLDRVLHETMRLIPAVPLL 362
            ..|.|:...|:.|..|.:||.||      |..||     .||:||..||.|:.||:|:.|:|||.
Mouse   340 WSLYLLGTNPEVQRKVDQELDEV------FGRSHRPVTLEDLKKLKYLDCVIKETLRVFPSVPLF 398

  Fly   363 IRQTSHSIQLSNGFYIPEGVTLMIDIFHTHRNKDIWGPQANAFNPDNFLPENKRARPPYSYLPFS 427
            .|..|...:: .|:.:.:|...:|..:..||:...: |....|.|:.|.|||.:.|.||:|:|||
Mouse   399 ARSLSEDCEV-GGYKVTKGTEAIIIPYALHRDPRYF-PDPEEFRPERFFPENSQGRHPYAYVPFS 461

  Fly   428 KGKKTCLGWKLSLISAKLALAKILRNYMLSTTFLYKDLRFIDNTTMKLAEQPLLAVKRR 486
            .|.:.|:|.|.:::..|..||.|||.:.:.:....::|....:..::......:.:|||
Mouse   462 AGPRNCIGQKFAVMEEKTILACILRQFWVESNQKREELGLAGDLILRPNNGIWIKLKRR 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a5	NP_650168.1	p450	33..458	CDD:299894	128/458 (28%)
Cyp4v3	NP_598730.1	p450	51..517	CDD:278495	129/483 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810