Protein Alignment Cyp313a5 and CYP3A7-CYP3A51P

DIOPT Version :10

• Sequence 1: NP_650168.1
• Gene: Cyp313a5 / 41486
• FlyBaseID: FBgn0038005
• Length: 487
• Species: Drosophila melanogaster
• Sequence 2: NP_001243426.2
• Gene: CYP3A7-CYP3A51P / 100861540
• HGNCID: 51504
• Length: 535
• Species: Homo sapiens
• Alignment Length: 527
• Identity: 129/527 - (24%)
• Similarity: 227/527 - (43%)
• Gaps: 90/527 - (17%)

  Fly     2 LTLQIFEAFAIILCVYFLWSRRRFYIM-MLKLPGPMGFPFIGLAFEYIRLKRKIRLRTILFKIYG 65
            |.::.:...|:.|.:.:|:..|...:. .|.:|||...||:|.|..:    || ...|...:.|.
Human     7 LAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSF----RK-GYWTFDMECYK 66

  Fly    66 KTVLTWIGL----TPVLVTCEPKILE--------DIFTSPNCSNRSSVVDKAISSCLGLGLLTLK 118
            |....| |:    .|:|...:|.:::        .:||:.........:..|||        ..:
Human    67 KYRKVW-GIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAIS--------IAE 122

  Fly   119 NNHWNERRKLLLPSFKNNAVLSFVPVLNNEANFLV-TLLAEFVDGGDINLLPELNKWSFKIAAQI 182
            :..|...|.||.|:|.:..:...||::....:.|| .|..|...|..:.|......:|..:....
Human   123 DEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITST 187

  Fly   183 TMGDEVRNQANYQNGNLLESYKAL---NNLIPIGV---VMPWLR------------NKYL----- 224
            :.|..:.:..|.|: ..:|:.|.|   |.|.|..:   |.|:|.            .|.:
Human   188 SFGVSIDSLNNPQD-PFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITVFPRKVISFLTK 251

  Fly   225 -------GKLFSYEKRRLEAATQSNAFIKDIIDKKLSSTDNSSEPALIDRILNLVRIGELSYDDV 282
                   |:|...:|.|::       |::.:||.: :|.|:.:..||.|.             ::
Human   252 SVKQIKEGRLKETQKHRVD-------FLQLMIDSQ-NSKDSETHKALSDL-------------EL 295

  Fly   283 MGEFSNIIFAASDTLSITVNNVLILMAMFPKYQDNVFEELAEVFPSGGEFEASHADLEKLVKLDR 347
            |.:....|||..:|.|..::.::..:|..|..|..|.:|:..|.|:  :...::..:.:|..||.
Human   296 MAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPN--KAPPTYDTVLQLEYLDM 358

  Fly   348 VLHETMRLIPAVPLLIRQTSHSIQLSNGFYIPEGVTLMIDIFHTHRNKDIWGPQANAFNPDNFLP 412
            |::||:||.|....|.|.....::: ||.:||:||.:||..:..|.:...| .:...|.|:.|..
Human   359 VVNETLRLFPVAMRLERVCKKDVEI-NGMFIPKGVVVMIPSYVLHHDPKYW-TEPEKFLPERFSK 421

  Fly   413 ENKRARPPYSYLPFSKGKKTCLGWKLSLISAKLALAKILRNYML---STTFLYKDLRFIDNTTMK 474
            :||....||.|.||..|.:.|:|.:.:|::.||||.::|:|:..   ..|.:...|||   ..:.
Human   422 KNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRF---GGLL 483

  Fly   475 LAEQPLL 481
            |.|:|::
Human   484 LTEKPIV 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a5	NP_650168.1	CYP313-like	65..482	CDD:410680	112/463 (24%)
CYP3A7-CYP3A51P	NP_001243426.2	CYP3A	67..492	CDD:410743	112/462 (24%)