DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp313a5 and cyp26c1

DIOPT Version :9

Sequence 1:	NP_650168.1	Gene:	Cyp313a5 / 41486	FlyBaseID:	FBgn0038005	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	XP_031761583.1	Gene:	cyp26c1 / 100489980	XenbaseID:	XB-GENE-1219115	Length:	608	Species:	Xenopus tropicalis

Alignment Length:	597	Identity:	127/597 - (21%)
Similarity:	230/597 - (38%)	Gaps:	177/597 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLTLQI-----FE-----AFAIILCV---YFLWSRR----RFYIMMLKLP-GPMGFPFIGLAFEY 47
            |..|:|     ||     |.:::|.:   :.|||.|    |.....|.|| |.||:||.|....:
Frog     1 MFLLEISYTSFFEAALTSALSLVLLLAASHQLWSLRWHSTRDRGSSLPLPKGSMGWPFFGETLHW 65

  Fly    48 I------RLKRKIRLRTILFK--IYGKTVLTWIGLTPVLVTCEPKIL--EDIFTSPNCSNRSSVV 102
            :      ...|:.:...| ||  :.||.|:...|...:     .|||  |....|......:.::
Frog    66 LVQGSSFHSSRREKYGNI-FKTHLLGKPVIRVTGAENI-----RKILLGEHHLVSTQWPQSTQII 124

  Fly   103 DKAISSCLGLGLLTLKNN----HWNERRKLLLPSFKNNAVLSFVPVLNNEANFLVTLLAEFVDGG 163
                     ||..||.|:    | .::||::.....:.|:.|::|.::....:.|......|  |
Frog   125 ---------LGSNTLSNSIGELH-RQKRKMMSKVLSSAALESYLPRIHEAVRWEVRSWCRGV--G 177

  Fly   164 DINLLPELNKWSFKIAAQITMGDEVRNQANYQNGNLLESYKAL-NNLIPIGVVMPWLRNKYLGKL 227
            .:::|......:|:|||:|.:|   .:..:.|...|..:::.| .||..:.:.:|
Frog   178 PVSMLSCAKALTFRIAARILLG---LSLTDTQFQELTRTFEQLVENLFCLPLDIP---------- 229

  Fly   228 FSYEKRRLEAATQSNAFIKDIIDKKLSSTDNSSEPALIDRILNLVRIG--ELSYDDVMGEFSNII 290
            ||..::.::|....:.::::.|.:|||..|..:....:|.::|..:.|  |::..::......:|
Frog   230 FSGLRKGMKARDTLHQYMEEAIKEKLSKRDPDACEDALDYLINSAKEGGKEINMQELKESAIELI 294

  Fly   291 FAASDTLSITVNNVLILMAMFPKYQDNVFEELA---------EVFPS------------------ 328
            |||..|.:....::::|:...|.....:.:|||         :..|:
Frog   295 FAAFLTTASASTSLVLLLLKHPSAIHKIRQELASHGLSEHCEQCLPATENPNNNILQDNGHQCLT 359

  Fly   329 --------------------------------------------GGE------------------ 331
                                                        .||
Frog   360 AGCQLPLVMGTEGQVKTLWEQTKQLLTDRTDQDPQNSLSSKNLVNGENRIQEAPCSHDKSNCSPV 424

  Fly   332 --------FEAS---HADLEKLVK---LDRVLHETMRLIPAVPLLIRQTSHSIQLSNGFYIPEGV 382
                    ||.:   :..||||..   ||.|:.|.:||:|.|....|....:.:| :|:.||:|.
Frog   425 PGKLQNSVFEGTCQQNISLEKLKSLHYLDCVVKEVLRLLPPVSGGYRTALQTFEL-DGYQIPKGW 488

  Fly   383 TLMIDIFHTHRNKDIWGPQANAFNPDNFLPENKRAR-PPYSYLPFSKGKKTCLGWKLSLISAKLA 446
            ::|..|..||....:: ..|..|:|:.|..|....: ..::|:||..|.::|:|.:|:.|
Frog   489 SVMYSIRDTHETAAVY-QNAEMFDPERFSTERDEGKLGRFNYIPFGGGARSCIGKELAQI----- 547

  Fly   447 LAKILRNYMLST 458
            :.|||...:::|
Frog   548 ILKILAMELVTT 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a5	NP_650168.1	p450	33..458	CDD:299894	112/546 (21%)
cyp26c1	XP_031761583.1	cytochrome_P450	59..588	CDD:425388	107/539 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910