Protein Alignment CG3916 and TMPRSS3

DIOPT Version :10

• Sequence 1: NP_650167.1
• Gene: CG3916 / 41484
• FlyBaseID: FBgn0038003
• Length: 267
• Species: Drosophila melanogaster
• Sequence 2: NP_076927.1
• Gene: TMPRSS3 / 64699
• HGNCID: 11877
• Length: 454
• Species: Homo sapiens
• Alignment Length: 281
• Identity: 84/281 - (29%)
• Similarity: 132/281 - (46%)
• Gaps: 45/281 - (16%)

  Fly     3 VLQLFCMLLILRQGLADVVTSTTESPTRINGGQRVNETVPFQVSLQMQRRGRWQHFCGGSIVSGQ 67
            |:.|.|.....|:|.:..:         :.|...:....|:|.|||.|    ..|.||||:::..
Human   199 VVTLQCTACGHRRGYSSRI---------VGGNMSLLSQWPWQASLQFQ----GYHLCGGSVITPL 250

  Fly    68 HVLTAAHCMEKMKV-EDVSVVVGTLNWKAGGLRHRLVTKHV-HPQYSMNPRIINDIALVKVTPPF 130
            .::|||||:..:.: :..::.||.::.........||.|.| |.:|... |:.|||||:|:..|.
Human   251 WIITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPK-RLGNDIALMKLAGPL 314

  Fly   131 RLERSDISTILIGGSDRIGEKVP----VRLTGWGST-------SPSTSSATLPDQLQALNYRTIS 184
            ..... |..:.:..|:   |..|    ...:|||:|       ||..:.|.:|         .||
Human   315 TFNEM-IQPVCLPNSE---ENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVP---------LIS 366

  Fly   185 NEDCNQK---GFRVTRNEICA-LAVQGQGACVGDSGGPLI-RPGKQPHLVGIVSYGSSTCAQGRP 244
            |:.||.:   |..::.:.:|| ....|..:|.|||||||: :..:...|||..|:|.......:|
Human   367 NKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKP 431

  Fly   245 DVYTRVSSFLPYISQVINQDL 265
            .|||||:|||.:|.:.:.:||
Human   432 GVYTRVTSFLDWIHEQMERDL 452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3916	NP_650167.1	Tryp_SPc	30..257	CDD:214473	76/244 (31%)
TMPRSS3	NP_076927.1	LDLa	74..107	CDD:238060
		SRCR_2	112..210	CDD:464747	3/10 (30%)
		Tryp_SPc	216..444	CDD:214473	76/254 (30%)