Protein Alignment Su(var)3-9 and KMT2D

DIOPT Version :10

• Sequence 1: NP_524357.2
• Gene: Su(var)3-9 / 41483
• FlyBaseID: FBgn0263755
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: NP_003473.3
• Gene: KMT2D / 8085
• HGNCID: 7133
• Length: 5537
• Species: Homo sapiens
• Alignment Length: 331
• Identity: 87/331 - (26%)
• Similarity: 134/331 - (40%)
• Gaps: 85/331 - (25%)

  Fly   331 PQKIGERALKSMQIKRAQFVRRKQLADLALFEKRMNHVEKPSPPIRVENNI--DLDTIDS--NFM 391
            ||.:..|.::.:.      ..||:...|.||.:.:...|.....:.....|  .|..::|  |::
Human  5260 PQAVWNRIIEPVA------AMRKEADMLRLFPEYLKGEELFGLTVHAVLRIAESLPGVESCQNYL 5318

  Fly   392 YIHDNIIGKDVP---KPEAGIVGCKCTE----------DTEECTASTKCC-ARFAGEL------- 435
            :.:......::|   .|    .||..:|          .|...|:.:|.. :.|.||.
Human  5319 FRYGRHPLMELPLMINP----TGCARSEPKILTHYKRPHTLNSTSMSKAYQSTFTGETNTPYSKQ 5379

  Fly   436 FAYERST--RRLRLRPGSAIYECNSRCSCDSSCSNRLVQHGRQVPLVLFKTANGSGWGVRAATAL 498
            |.:.:|:  ||||....:.:|...||.                           .|.|:.||..|
Human  5380 FVHSKSSQYRRLRTEWKNNVYLARSRI---------------------------QGLGLYAAKDL 5417

  Fly   499 RKGEFVCEYIGEIITSDEANERGKAYDDNGR-TYLFDLDYNTAQDSEYTIDAANYGNISHFINHS 562
            .|...|.||||.||.::.||.|.|.|::..| .|:|.:      ::|:.|||...|..:.:||||
Human  5418 EKHTMVIEYIGTIIRNEVANRREKIYEEQNRGIYMFRI------NNEHVIDATLTGGPARYINHS 5476

  Fly   563 CDPNLAVFPCWIEHLNV-ALPHLVFFTLRPIKAGEELSFDYIRADNEDVPYENLSTAVRVECRCG 626
            |.||     |..|.:.. ....::..:.|.|..||||::|| :.|.||..:       ::.|.||
Human  5477 CAPN-----CVAEVVTFDKEDKIIIISSRRIPKGEELTYDY-QFDFEDDQH-------KIPCHCG 5528

  Fly   627 ADNCRK 632
            |.||||
Human  5529 AWNCRK 5534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-9	NP_524357.2	PTZ00327	11..>80	CDD:240362
		Chromo	219..268	CDD:459793
		SET_SUV39H	388..634	CDD:380940	76/272 (28%)
KMT2D	NP_003473.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..60
		ePHD1_KMT2D	134..217	CDD:277165
		PHD1_KMT2C_like	228..273	CDD:276984
		PHD_SF	275..320	CDD:473978
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	368..387
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	393..416
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	436..1331
		15 X 5 AA repeats of S/P-P-P-E/P-E/A	439..668
		PHA03247	<469..860	CDD:223021
		PHA03247	<690..1272	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1340..1359
		PHD3_KMT2D	1378..1428	CDD:277072
		PHD5_KMT2C_like	1429..1475	CDD:276988
		PHD5_KMT2D	1506..1556	CDD:277074
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1610..1767
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1793..1889
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1904..2002
		HMG-box_KMT2D	1995..2078	CDD:438836
		PHA03247	<2108..2600	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2165..2683
		LXXLL motif 1	2686..2690
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2697..2814
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2835..2996
		LXXLL motif 2	3038..3042
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3078..3110
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3147..3209
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3263..3339
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3462..3499
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3596..3673
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3758..3802
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3984..4191
		PHA03247	<4162..4426	CDD:223021
		LXXLL motif 3	4222..4226
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	4233..4398
		LXXLL motif 4	4253..4257
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	4410..4452
		LXXLL motif 5	4463..4467
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	4503..4544
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	4613..4727
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	4822..4857
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	4905..4980
		LXXLL motif 6	4990..4994
		ePHD2_KMT2D	5032..5138	CDD:277168
		FYRN	5181..5232	CDD:461787
		FYRC	5240..5327	CDD:197781	13/72 (18%)
		WDR5 interaction motif (WIN). /evidence=ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:22665483	5337..5342		2/4 (50%)
		SET_KMT2D	5382..5536	CDD:380986	62/199 (31%)