DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(var)3-9 and Ehmt1

DIOPT Version :9

Sequence 1:	NP_524357.2	Gene:	Su(var)3-9 / 41483	FlyBaseID:	FBgn0263755	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	XP_006498485.1	Gene:	Ehmt1 / 77683	MGIID:	1924933	Length:	1312	Species:	Mus musculus

Alignment Length:	668	Identity:	168/668 - (25%)
Similarity:	261/668 - (39%)	Gaps:	191/668 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 GKSTVVKAISGVQTVRFKNELERNITIKLERLSEKKI----KNLLTSKQQRQQYEI--------- 103
            |.:.:|:..||:.....|..|| :..|.|:....||:    |.|..|.:|.:..::
Mouse   714 GPAGLVRPTSGLSQGPGKETLE-SALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGID 777

  Fly   104 --------KQRSMLRHLAELRRHSRFRRLCTKPASSSMPASTSSVDRRTTRRSTSQTSLSPSNSS 160
                    .:||.|...||.....    :|.....:.....|.|.|:||.....:
Mouse   778 PNFKMEHQSKRSPLHAAAEAGHVD----ICHMLVQAGANIDTCSEDQRTPLMEAA---------- 828

  Fly   161 GYGSVFGCEEHDVDKIPSLNGFAKLKRRRSSCVGAPT-PNSKRSKNNMGVIAKRPPKGEYVVER- 223
                    |.:.:|.:..|     :|      .||.. |........:.:.||   ||.|.|.:
Mouse   829 --------ENNHLDAVKYL-----IK------AGAQVDPKDAEGSTCLHLAAK---KGHYDVVQY 871

  Fly   224 --------IEC---------VEMDQYQPVFFVKWL-------GYHDSENT----WESLANVADCA 260
                    :.|         :...:|:.|..||.|       ...|:|..    |.:.:...|.|
Mouse   872 LLSNGQMDVNCQDDGGWTPMIWATEYKHVELVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIA 936

  Fly   261 EMEKFVERHQQLYEIYIAKITTELEKQLEALPLMENITVAEVDAYEPLNL-----QIDLILLAQY 320
            |:            :..||.               ::....:....||::     :.|.::|...
Mouse   937 EI------------LLAAKC---------------DLHAVNIHGDSPLHIAARENRYDCVVLFLS 974

  Fly   321 RAAGSRSQREPQKIGERALK----SMQIKRAQFVRRKQLADLALFEKRMNHVEKPSPPIRVE--- 378
            |.:....:   .|.||..|:    |.|:..| ....|.|.|.|           |..|:.||
Mouse   975 RDSDVTLK---NKEGETPLQCASLSSQVWSA-LQMSKALRDSA-----------PDKPVAVEKTV 1024

  Fly   379 ----------------NNIDLDTIDSNFMYIHDNIIGK--DVPKPEAGIVGCKCTEDTEECTAST 425
                            |.:|.:...:|:.|:..|.:..  ::.:....:..|.|.:|   |::||
Mouse  1025 SRDIARGYERIPIPCVNAVDSELCPTNYKYVSQNCVTSPMNIDRNITHLQYCVCVDD---CSSST 1086

  Fly   426 KCCARFAGELFAYERSTRRL---RLRPGSAIYECNSRCSCDSSCSNRLVQHGRQVPLVLFKTANG 487
            ..|.:.:...: |::..|.|   .:.....|:|||..|||..:|.||:||:|.:..|.|::|.:
Mouse  1087 CMCGQLSMRCW-YDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTQD- 1149

  Fly   488 SGWGVRAATALRKGEFVCEYIGEIITSDEANERGKAYDDNGRTYLFDLDYNTAQDSE-YTIDAAN 551
            .|||||:...:..|.|||||:||:|:..||:.|.:      .:||||||   .:|.| |.|||..
Mouse  1150 MGWGVRSLQDIPLGTFVCEYVGELISDSEADVREE------DSYLFDLD---NKDGEVYCIDARF 1205

  Fly   552 YGNISHFINHSCDPNLAVFPCWIEHLNVALPHLVFFTLRPIKAGEELSFDYIRADNE---DVPYE 613
            |||:|.||||.|:|||.....::.|.::..|.:.||:.|.|:|||:|.|||    .|   ||..:
Mouse  1206 YGNVSRFINHHCEPNLVPVRVFMSHQDLRFPRIAFFSTRLIQAGEQLGFDY----GERFWDVKGK 1266

  Fly   614 NLSTAVRVECRCGADNCR 631
            ..|      ||||:..||
Mouse  1267 LFS------CRCGSSKCR 1278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-9	NP_524357.2	P-loop_NTPase	41..>80	CDD:304359	8/27 (30%)
		CHROMO	217..268	CDD:237991	15/79 (19%)
		PreSET	362..455	CDD:128744	20/116 (17%)
		SET	477..609	CDD:214614	58/135 (43%)
Ehmt1	XP_006498485.1	PHA03095	768..>994	CDD:222980	47/291 (16%)
		ANK repeat	788..817	CDD:293786	7/32 (22%)
		ANK repeat	819..850	CDD:293786	10/59 (17%)
		Ank_2	824..917	CDD:372319	19/124 (15%)
		ANK repeat	852..884	CDD:293786	7/34 (21%)
		ANK repeat	886..917	CDD:293786	5/30 (17%)
		ANK repeat	919..950	CDD:293786	7/57 (12%)
		ANK repeat	952..983	CDD:293786	5/33 (15%)
		SET_EHMT1	1050..1280	CDD:380933	93/253 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R211
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840