DRSC/TRiP Functional Genomics Resources

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Protein Alignment Su(var)3-9 and Kmt2b

DIOPT Version :10

Sequence 1:NP_524357.2 Gene:Su(var)3-9 / 41483 FlyBaseID:FBgn0263755 Length:635 Species:Drosophila melanogaster
Sequence 2:NP_001277502.1 Gene:Kmt2b / 75410 MGIID:109565 Length:2722 Species:Mus musculus


Alignment Length:424 Identity:103/424 - (24%)
Similarity:156/424 - (36%) Gaps:148/424 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   291 LPLMENITVAEVDAYEPLNLQIDLILLAQYR--AAGSRSQRE-------------PQKIGER--- 337
            |||.|..:.|       |:...||:..:|:.  :||..|..|             |:::|..   
Mouse  2366 LPLAEAPSQA-------LDGSSDLLFESQWHHYSAGEASSSEEEPPSPEDKENQVPKRVGPHLRF 2423

  Fly   338 ----------ALKSMQIKRAQFVRRKQLA------------------------DLALF------- 361
                      ..:|:::.....:.:.|.|                        |..:|       
Mouse  2424 EISSDDGFSVEAESLEVAWRTLIEKVQEARGHARLRHLSFSGMSGARLLGIHHDAVIFLAEQLPG 2488

  Fly   362 EKRMNHVE---------KPSPPI------RVENNIDLDTIDS-NFMYIHDNIIGKDVPKPEAGIV 410
            .:|..|.:         :..||:      |.|..:...|.|. ||:.....::      ||    
Mouse  2489 AQRCQHYKFRYHQQGEGQEEPPLNPHGAARAEVYLRKCTFDMFNFLASQHRVL------PE---- 2543

  Fly   411 GCKCTEDTEECTASTKCCARFAGELFAYERSTRR---LRLRPGSAIYECNSRCSCDSSCSNRLVQ 472
            |..|.|:.:|...                |||||   |.| |.:..:....:.|.::....|...
Mouse  2544 GATCDEEEDEVQL----------------RSTRRATSLEL-PMAMRFRHLKKTSKEAVGVYRSAI 2591

  Fly   473 HGRQVPLVLFKTANGSGWGVRAATALRKGEFVCEYIGEIITSDEANERGKAYDDNG-RTYLFDLD 536
            |||               |:.....:..||.|.||.|.:|.|...::|.|.||..| ..|:|.:|
Mouse  2592 HGR---------------GLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYDGKGIGCYMFRMD 2641

  Fly   537 YNTAQDSEYTIDAANYGNISHFINHSCDPNLAVFPCWIEHLNV-ALPHLVFFTLRPIKAGEELSF 600
                 |.: .:||..:||.:.||||||:||     |:...::| ...|:|.|.||.|..||||::
Mouse  2642 -----DFD-VVDATMHGNAARFINHSCEPN-----CFSRVIHVEGQKHIVIFALRRILRGEELTY 2695

  Fly   601 DYIRADNEDVPYENLSTAVRVECRCGADNCRKVL 634
            ||      ..|.|:.|.  ::.|.|||..||:.|
Mouse  2696 DY------KFPIEDASN--KLPCNCGAKRCRRFL 2721

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Su(var)3-9NP_524357.2 PTZ00327 11..>80 CDD:240362
Chromo 219..268 CDD:459793
SET_SUV39H 388..634 CDD:380940 74/251 (29%)
Kmt2bNP_001277502.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..65
Menin-binding motif (MBM). /evidence=ECO:0000250|UniProtKB:Q9UMN6 17..36
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 82..524
PHA03378 <483..>702 CDD:223065
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 542..783
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 831..872
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 899..964
zf-CXXC 963..1010 CDD:366873
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1032..1076
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1088..1138
PHD1_KMT2B 1209..1255 CDD:277064
PHD2_KMT2B 1257..1306 CDD:277066
PHD3_KMT2B 1343..1399 CDD:277068
Bromo_ALL-1 1380..1522 CDD:99925
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1550..1572
ePHD_KMT2B 1587..1691 CDD:277164
FYRN 1739..1786 CDD:461787
PHA03307 1814..>2193 CDD:223039
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2065..2113
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2125..2169
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2288..2365
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2391..2417 5/25 (20%)
FYRC 2420..2504 CDD:197781 7/83 (8%)
WDR5 interaction motif (WIN). /evidence=ECO:0000250|UniProtKB:Q9UMN6 2515..2520 1/4 (25%)
SET_KMT2A_2B 2569..2722 CDD:380947 59/187 (32%)
Blue background indicates that the domain is not in the aligned region.

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