DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(var)3-9 and SUV39H1

DIOPT Version :9

Sequence 1:	NP_524357.2	Gene:	Su(var)3-9 / 41483	FlyBaseID:	FBgn0263755	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_001269095.1	Gene:	SUV39H1 / 6839	HGNCID:	11479	Length:	423	Species:	Homo sapiens

Alignment Length:	484	Identity:	168/484 - (34%)
Similarity:	245/484 - (50%)	Gaps:	98/484 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 CEEHDVDKIPSLNGFAKLKRRRSSCVGAPTPNSKRSKNNMGVIAKRPPKGEYVVERIECVEMDQY 232
            |.:...:::..|...|||     ||     |....||.|:         .::.||.:...:..:.
Human    22 CCKSSWNQLQDLCRLAKL-----SC-----PALGISKRNL---------YDFEVEYLCDYKKIRE 67

  Fly   233 QPVFFVKWLGYHDSENTWESLANVADCAEMEKFVERHQQLYEIYIAKITTELEKQLEALPLMENI 297
            |..:.|||.||.|||:|||...|:       |.|...:|.::        :||::|
Human    68 QEYYLVKWRGYPDSESTWEPRQNL-------KCVRILKQFHK--------DLEREL--------- 108

  Fly   298 TVAEVDAYEPLNLQIDLILLAQYRAAGSRSQREPQKIGERALKSMQIKRAQFVRRKQLADLALFE 362
                              |...:|:      :.|:.: :.:|.:..:::|     ||...|..:|
Human   109 ------------------LRRHHRS------KTPRHL-DPSLANYLVQKA-----KQRRALRRWE 143

  Fly   363 KRMNHVEKPSPPIRVENNIDLDTIDSNFMYIHDNIIGKDVPKPEAGIVGCKCTEDTEEC--TAST 425
            :.:|........|.|||.:|||.....|:||::..:|:.:...:.. |||:|    ::|  ..:.
Human   144 QELNAKRSHLGRITVENEVDLDGPPRAFVYINEYRVGEGITLNQVA-VGCEC----QDCLWAPTG 203

  Fly   426 KCCARFAGELFAYERSTRRLRLRPGSAIYECNSRCSCDSSCSNRLVQHGRQVPLVLFKTANGSGW 490
            .||...:...||| ....::|||.|..||||||||.|...|.||:||.|.:..|.:|:|.:|.||
Human   204 GCCPGASLHKFAY-NDQGQVRLRAGLPIYECNSRCRCGYDCPNRVVQKGIRYDLCIFRTDDGRGW 267

  Fly   491 GVRAATALRKGEFVCEYIGEIITSDEANERGKAYDDNGRTYLFDLDYNTAQDSEYTIDAANYGNI 555
            |||....:||..||.||:||||||:||..||:.||..|.||||||||   .:..||:|||.||||
Human   268 GVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDY---VEDVYTVDAAYYGNI 329

  Fly   556 SHFINHSCDPNLAVFPCWIEHLNVALPHLVFFTLRPIKAGEELSFDY-IRADNEDVPYENLST-- 617
            |||:||||||||.|:..:|::|:..||.:.||..|.|:|||||:||| ::.|..|:....:.:
Human   330 SHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIRAGEELTFDYNMQVDPVDMESTRMDSNF 394

  Fly   618 -----------AVRVECRCGADNCRKVLF 635
                       .||:||:||.::|||.||
Human   395 GLAGLPGSPKKRVRIECKCGTESCRKYLF 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-9	NP_524357.2	P-loop_NTPase	41..>80	CDD:304359
		CHROMO	217..268	CDD:237991	17/50 (34%)
		PreSET	362..455	CDD:128744	28/94 (30%)
		SET	477..609	CDD:214614	74/132 (56%)
SUV39H1	NP_001269095.1	CD_SUV39H1_like	54..102	CDD:349289	18/54 (33%)
SUV39H1	NP_001269095.1	SET_SUV39H1	169..423	CDD:380923	117/262 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143354
Domainoid	1	1.000	148	1.000	Domainoid score	I4476
eggNOG	1	0.900	-	-		E2759_KOG1082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	253	1.000	Inparanoid score	I3207
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D589939at33208
OrthoFinder	1	1.000	-	-		FOG0001837
OrthoInspector	1	1.000	-	-		otm41746
orthoMCL	1	0.900	-	-		OOG6_100876
Panther	1	1.100	-	-	LDO	PTHR46223
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R211
SonicParanoid	1	1.000	-	-		X219
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.790