Protein Alignment Su(var)3-9 and ash1l

DIOPT Version :10

• Sequence 1: NP_524357.2
• Gene: Su(var)3-9 / 41483
• FlyBaseID: FBgn0263755
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: XP_005159540.1
• Gene: ash1l / 563799
• ZFINID: ZDB-GENE-030131-6101
• Length: 2988
• Species: Danio rerio
• Alignment Length: 798
• Identity: 168/798 - (21%)
• Similarity: 271/798 - (33%)
• Gaps: 273/798 - (34%)

  Fly    20 SNLDVSKLTPLSPEVISRQATINIGTI--GHVAH----GKSTVVKAISGVQ-------TVRFKNE 71
            |:.|.|||:       ..|:....|..  |||.:    .:|....|.|.::       |..|.:.
Zfish  1548 SDTDYSKLS-------RNQSFSGSGAFSEGHVQNPVDCSESDEEDAASPIEEPEISHHTNLFASA 1605

  Fly    72 LERNITIK--------------LERLSEKKIKNLLTSKQQRQ-------QYEIKQRSM------L 109
            |.|. ::|              |.||.....::..||.::|:       |..:.|.|:      |
Zfish  1606 LSRT-SLKGSRSKKGGPLESPSLSRLDRTVRRDRSTSSEKREIGNVSSLQNRVGQSSVPDVSEGL 1669

  Fly   110 RHLAELRRHSRFRRLCTKPASSSMPASTSSVDRRTTRRSTSQTSLSPSNSSGYGSVFGCEEHDVD 174
            .|   ...|.....|....|:|.:|..|......|.....|....|||..|...:.  |    :|
Zfish  1670 HH---RHHHHHHPPLSLSHAASCLPHCTLDQPGNTAPLRPSSRQASPSTCSSQPAC--C----LD 1725

  Fly   175 KIPS--------------LNGFAKLKRRRSSCVGAPTPNSKRSKNNMGVIAKRPP---------- 215
            ..||              :|...:.|:.:         ...|:.|||  :.||.|
Zfish  1726 SPPSHLSHRPPPKNNLLHVNKILRAKKLQ---------RQARTGNNM--VKKRGPGRPRKNPLPS 1779

  Fly   216 ---------------------------KGEYVVERIECVEMDQYQPVFFVK-W----LGYHDSEN 248
                                       :.:.||:.||.|..:|.:.....| |    .|..:.|.
Zfish  1780 PPATPPPQTSEQDNHPLPERHRATALWEADTVVDAIEAVVQNQRKKGRKRKHWERETEGGDEEEE 1844

  Fly   249 TWESLANVADCAEMEKFVERHQQ---LYEIYIAKITTELEKQLEALPLMENITVAEVDAYEPLNL 310
            ..|....|.| .|.|:..|:.||   ..:..::::.||..:|.        :|..||..:..
Zfish  1845 DAEEERQVED-EEEEEDEEQEQQSAAREDDVMSRVRTEGSRQW--------LTQEEVHCFRS--- 1897

  Fly   311 QIDLILLAQYRAAGS-----------------RSQRE------PQKIGERA-------------L 339
                  ..:.:..||                 .||||      |:|..::|             .
Zfish  1898 ------ALEGKPDGSPERPGPATSEPTPNPSVTSQREKRVARPPKKKFQKAGLYSDVYKTDDPRS 1956

  Fly   340 KSMQIKRAQFVRRKQLADLALFEKRMNHVEKPSPPIRVENNIDLDTIDSNFMYIHDNIIGK-DVP 403
            :.:|:|:.:........|..|....: ||.|.....|::..:..|.:   :::.||.:..: |||
Zfish  1957 QLLQLKKEKLEYTPGEHDYGLLPAPI-HVGKYLRQKRIDFQLPYDIL---WLWKHDQLYKRPDVP 2017

  Fly   404 -------------KP----EAGIVGCKCTEDTEECTASTKCCARFAGELFAYERSTRRLRLRPGS 451
                         ||    ||....|:..:|:.|......|..|.
Zfish  2018 LYKKIRSNVYVDVKPLSGYEATTCNCRLPDDSSEKGCQDDCLNRM-------------------- 2062

  Fly   452 AIY-ECN-SRCSCDSSCSNRLVQHGRQVPLVLFKTANGSGWGVRAATALRKGEFVCEYIGEIITS 514
             || ||: |.|.|...|.|:.:|....|..:....|.|.|||:|....||.|:|:.||:||:::.
Zfish  2063 -IYAECSPSTCPCSDQCDNQRIQKHEWVQCLERFRAEGKGWGIRTKQPLRAGQFIIEYLGEVVSE 2126

  Fly   515 DE---------------------------ANERGKAYDDNGRTYLFDLDYNTAQDSEYTIDAANY 552
            .|                           .:...:.|..:...|..:|      ||...||:...
Zfish  2127 QEFRKYIASDCRLHQVKIPMLGENKKQIGVSRMMEQYFSHSGHYCLNL------DSGMVIDSYRM 2185

  Fly   553 GNISHFINHSCDPNLAVFPCWIEHLNV-ALPHLVFFTLRPIKAGEELSFDYIRADNEDVPYENLS 616
            ||.:.|:||||:||     |.::..:| .:..:..|.|:.|.:|.||::||        .:.:.:
Zfish  2186 GNEARFVNHSCEPN-----CEMQKWSVNGVYRIGLFALKDINSGTELTYDY--------NFHSFN 2237

  Fly   617 TAVRVECRCGADNCRKVL 634
            |..:..|:||::.||.::
Zfish  2238 TEEQQVCKCGSEGCRGII 2255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-9	NP_524357.2	PTZ00327	11..>80	CDD:240362	18/86 (21%)
		Chromo	219..268	CDD:459793	15/53 (28%)
		SET_SUV39H	388..634	CDD:380940	72/293 (25%)
ash1l	XP_005159540.1	PHA03307	305..>647	CDD:223039
		PHA03247	<480..906	CDD:223021
		CytochromB561_N	<540..>674	CDD:480696
		AWS	2037..2088	CDD:197795	17/71 (24%)
		SET_ASH1L	2091..2257	CDD:380951	47/184 (26%)
		COG5076	2281..>2500	CDD:227408
		Bromo_ASH1	2408..2513	CDD:99955
		PHD_ASH1L	2559..2601	CDD:277023
		BAH_polybromo	2633..2772	CDD:240068