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Protein Alignment Su(var)3-9 and ASH1L

DIOPT Version :10

Sequence 1:	NP_524357.2	Gene:	Su(var)3-9 / 41483	FlyBaseID:	FBgn0263755	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_001353106.1	Gene:	ASH1L / 55870	HGNCID:	19088	Length:	2969	Species:	Homo sapiens

Alignment Length:	671	Identity:	141/671 - (21%)
Similarity:	244/671 - (36%)	Gaps:	206/671 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 KLERLSEKKIKNLLTSKQQRQQYEIKQRSMLRHLAEL---------RRHSRFRRLCTKPASSSMP 134
            :|....:..:.:||....|.:..|..::|:...:|..         |.||:.|.| .||.|..:|
Human  1705 RLVASGDDSVDSLLQRMVQNEDQEPMEKSIDAVIATASAPPSSSPGRSHSKDRTL-GKPDSLLVP 1768

  Fly   135 ASTS-SVDRRTTRRSTSQTSLSPSNSSGYGSVFGCEEHDV------------------DKI---- 176
            |.|| |.:...:..|...||             .|..|.:                  |||
Human  1769 AVTSDSCNNSISLLSEKLTS-------------SCSPHHIKRSVVEAMQRQARKMCNYDKILATK 1820

  Fly   177 ---PSLNGFAKLKRRRSSCVGAPTPNSKRSKNNMGVIAKRPPKGEYVVERIEC-----VEMDQYQ 233
               ..:|...|.|:.:         ...|:.||.  :.:||.:..      :|     |.|..:|
Human  1821 KNLDHVNKILKAKKLQ---------RQARTGNNF--VKRRPGRPR------KCPLQAVVSMQAFQ 1868

  Fly   234 PVFFVKWLGYHDSEN-----TWESLANVADCA--------EMEKFVERHQQLYEIYIAKITTELE 285
            ...||......|.|.     :.:::.:|.:..        |.:|.::|...|.|       .:..
Human  1869 AAQFVNPELNRDEEGAALHLSPDTVTDVIEAVVQSVNLNPEHKKGLKRKGWLLE-------EQTR 1926

  Fly   286 KQLEALPLME------NITVAEVDAYEP-----------LNLQIDLILLAQYRAAGSRSQREPQK 333
            |:.:.||..|      :...|.|:...|           ..||..|.|:.:.:......:::.||
Human  1927 KKQKPLPEEEEQENNKSFNEAPVEIPSPSETPAKPSEPESTLQPVLSLIPREKKPPRPPKKKYQK 1991

  Fly   334 IG---------ERALKSMQIKR--------------------------AQFVRRK----QLADLA 359
            .|         :...:.:|:|:                          .:::|:|    ||....
Human  1992 AGLYSDVYKTTDPKSRLIQLKKEKLEYTPGEHEYGLFPAPIHVVFFVSGKYLRQKRIDFQLPYDI 2056

  Fly   360 LFEKRMNHV-EKPSPPI--RVENNIDLDTIDSNFMYIHDNIIGKDVPKPEAGIVGCKCTEDTEEC 421
            |::.:.|.: :||..|:  ::.:|:.:|.              |.:...||....||..:|....
Human  2057 LWQWKHNQLYKKPDVPLYKKIRSNVYVDV--------------KPLSGYEATTCNCKKPDDDTRK 2107

  Fly   422 TASTKCCARFAGELFAYERSTRRLRLRPGSAIYECN-SRCSCDSSCSNRLVQHGRQVPLVLFKTA 485
            .....|..|.   :||                 ||: :.|.|...|.|:.:|....|..:....|
Human  2108 GCVDDCLNRM---IFA-----------------ECSPNTCPCGEQCCNQRIQRHEWVQCLERFRA 2152

  Fly   486 NGSGWGVRAATALRKGEFVCEYIGEIITSDE-ANERGKAYDDNGRTYLFDLDYNTAQDSEYTIDA 549
            ...|||:|....|:.|:|:.||:||:::..| .|...:.|.::...|..:|      ||...||:
Human  2153 EEKGWGIRTKEPLKAGQFIIEYLGEVVSEQEFRNRMIEQYHNHSDHYCLNL------DSGMVIDS 2211

  Fly   550 ANYGNISHFINHSCDPNLAVFPCWIEHLNV-ALPHLVFFTLRPIKAGEELSFDYIRADNEDVPYE 613
            ...||.:.|||||||||     |.::..:| .:..:..:.|:.:.||.||::||        .:.
Human  2212 YRMGNEARFINHSCDPN-----CEMQKWSVNGVYRIGLYALKDMPAGTELTYDY--------NFH 2263

  Fly   614 NLSTAVRVECRCGADNCRKVL 634
            :.:...:..|:||.:.||.::
Human  2264 SFNVEKQQLCKCGFEKCRGII 2284

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.