DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(var)3-9 and ash1

DIOPT Version :9

Sequence 1:	NP_524357.2	Gene:	Su(var)3-9 / 41483	FlyBaseID:	FBgn0263755	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster

Alignment Length:	756	Identity:	153/756 - (20%)
Similarity:	256/756 - (33%)	Gaps:	203/756 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 DLSNLDVSKLTPLSPEVISRQATINIGTIGHVAHGKSTVVKAISGVQTVR--------FKNELER 74
            |.:::...||..:||   |...::.....|..|..|.:..|.:..:|:..        |:..:|.
  Fly   838 DNNSISGGKLLDISP---SSLCSLKQQRRGGAAKQKVSAAKDLVQLQSPAGSYPPPGVFEPSVEL 899

  Fly    75 NITIKLERLSEKKIKNLLTSKQQRQQYEIKQ---RSMLRHLAELRRHSRFRRLCTKPASSSMPAS 136
            .|.|.|.:|:|..|.............:||:   :.:.:.:.|...|.....|..|.....:..:
  Fly   900 EIQIPLSKLNESVITKAEVESPLLSALDIKEDTKKEVGQRVVETLLHKTGGNLLLKRKRKKINRT 964

  Fly   137 TSSVDRRTTRRST--SQT-------------------SLSPSNSSGYGSVFGCEEHDVD------ 174
            .....||..|:.:  .||                   ||..:.||...:|.......:|
  Fly   965 GFPTVRRKKRKVSVEQQTTAVIDEHEPEFDPDDEPLQSLRETRSSNNVNVQAAPNPPLDCERVPQ 1029

  Fly   175 --------------KIPSLNGFA--KLKRRRSSCVGAPTPNSKRSKNNMGVIAKRPPKGEYVVER 223
                          |.|.|:..|  :|:|.::...|.|.....:::.......:.|||.|..:..
  Fly  1030 AGEARETFVARTNQKAPRLSVVALERLQRPQTPARGRPRGRKPKNREQAEAAPQPPPKSEPEIRP 1094

  Fly   224 IECVEMDQYQPVFFVKWLGYHDSENTWESLANVADCAEMEKFVERHQQLYE------IYIAKITT 282
            .:.......|||.              |.........:.:..:|.:.:|.:      .:..||..
  Fly  1095 AKKRGRQPKQPVL--------------EEPPPTPPPQQKKNKMEPNIRLPDGIDPNTNFSCKIRL 1145

  Fly   283 ELEKQLEA---------------------LPLMENITVAEVDA--YEPLNLQIDLILLAQYRAAG 324
            :..|.|||                     :|:.:....||.:|  .:.:..:.|.:..::....|
  Fly  1146 KRRKNLEAGTQPKKEKPVQPVTVEEIPPEIPVSQEEIDAEAEAKRLDSIPTEHDPLPASESHNPG 1210

  Fly   325 SRSQREPQKIGERALKSMQIKRAQFVRRKQLADLALFEKRMNHVEK------------------- 370
            .:......:..|....:..:::...|::..|. ..||.   ||.::
  Fly  1211 PQDYASCSESSEDKASTTSLRKLSKVKKTYLV-AGLFS---NHYKQSLMPPPAKVNKKPGLEEQV 1271

  Fly   371 ------PSPPI------RVENNIDL----------------DTIDS-NFMYIHDNIIGKDVPKPE 406
                  |.||.      |.|.:.:|                :.:.| |:..|..|:..:.|....
  Fly  1272 GPASLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPSWNYRKIRTNVYAESVRPNL 1336

  Fly   407 AGIVGCKCTEDTEECTASTKCCARFAGELFAYERSTRRLRLRPGSAIY-ECN-SRCSCDSSCSNR 469
            ||.       |...|....:      ||....:....|:       :| ||: |.|.....|.|:
  Fly  1337 AGF-------DHPTCNCKNQ------GEKSCLDNCLNRM-------VYTECSPSNCPAGEKCRNQ 1381

  Fly   470 LVQHGRQVPLV-LFKTANGSGWGVRAATALRKGEFVCEYIGEIITSDEANER-GKAYDDNGRTYL 532
            .:|.....|.| .|.||: .|||||....:.||.::.||:||::|..|..:| ...|.::...|.
  Fly  1382 KIQRHAVAPGVERFMTAD-KGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHHYC 1445

  Fly   533 FDLDYNTAQDSEYTIDAANYGNISHFINHSCDPNLAVFPCWIEHLNV-ALPHLVFFTLRPIKAGE 596
            ..|      |....||....|:...|:||||:||     |.::..:| .|..:|.|..|.|:.||
  Fly  1446 LHL------DGGLVIDGQRMGSDCRFVNHSCEPN-----CEMQKWSVNGLSRMVLFAKRAIEEGE 1499

  Fly   597 ELSFDY---IRADNEDVPYENLSTAVRVECRCGADNCRKVL 634
            ||::||   :...:|..|           |||....||.|:
  Fly  1500 ELTYDYNFSLFNPSEGQP-----------CRCNTPQCRGVI 1529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-9	NP_524357.2	P-loop_NTPase	41..>80	CDD:304359	9/46 (20%)
		CHROMO	217..268	CDD:237991	5/50 (10%)
		PreSET	362..455	CDD:128744	21/141 (15%)
		SET	477..609	CDD:214614	46/137 (34%)
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795	13/60 (22%)
		SET	1392..1512	CDD:214614	45/131 (34%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467616
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840