DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(var)3-9 and Ehmt2

DIOPT Version :9

Sequence 1:	NP_524357.2	Gene:	Su(var)3-9 / 41483	FlyBaseID:	FBgn0263755	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	XP_006256016.2	Gene:	Ehmt2 / 361798	RGDID:	1302972	Length:	1273	Species:	Rattus norvegicus

Alignment Length:	631	Identity:	161/631 - (25%)
Similarity:	252/631 - (39%)	Gaps:	182/631 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 KNELERNITIKLERL-----SEKKIKNL-LTSKQQRQQYEI----------------KQRSMLRH 111
            :.||::.|.:.|:.|     |:::.|.. |.:..|:...||                :||:.|..
  Rat   723 QGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLME 787

  Fly   112 LAELRRHSRFRR--------LCTKPASSSM----PASTSSVDRRTTRRSTSQTSLSPSNSSGYGS 164
             |.:..|....|        :.:|....|.    .|...:::..:...||.|..::..:|.|:..
  Rat   788 -AVVNNHLEVARYMVQLGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTP 851

  Fly   165 VFGCEEH-DVDKIPSLNGFAKLKRRRSSCVGAPTPNSKRSKN---------NMGVIAKRPPKGEY 219
            :....|| .:|.|..|     |.|      ||....:...:|         ....||:
  Rat   852 IIWAAEHKHIDVIRML-----LTR------GADVTLTDNEENICLHWASFTGSAAIAE------- 898

  Fly   220 VVERIEC----VEMDQYQPVFFVKWLGYHDSENTWESLANVADCAEMEKFVERHQQLYEIYIAKI 280
            |:...:|    |......|:.......||             ||..:  |:.|
  Rat   899 VLLNAQCDLHAVNYHGDTPLHIAARESYH-------------DCVLL--FLSR------------ 936

  Fly   281 TTELEKQLEALPLMEN--------ITVAEVDAYEPLNLQIDLILLAQYRAAGSRSQREPQKIGER 337
                    .|.|.:.|        :|....|.:..|.|...|.|                .:|.|
  Rat   937 --------GANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRL----------------GVGNR 977

  Fly   338 ALKSMQIKRAQFVRRKQLADLALFEKRMNHVEKPSPPIRVENNIDLDTIDSNFMYIHDNI----- 397
            |:::.:|......|..:                 :.||...|.:|.:....::.||.:|.
  Rat   978 AVRTEKIICRDVARGYE-----------------NVPIPCVNGVDGEPCPEDYKYISENCETSTM 1025

  Fly   398 -IGKDVPKPEAGIVGCKCTEDTEECTASTKCCARFAGELFAYERSTRRL----RLRPGSAIYECN 457
             |.:::    ..:..|.|.:|   |::|...|.:.:...: |::..|.|    ::.| ..|:|||
  Rat  1026 NIDRNI----THLQHCTCVDD---CSSSNCLCGQLSIRCW-YDKDGRLLQEFNKIEP-PLIFECN 1081

  Fly   458 SRCSCDSSCSNRLVQHGRQVPLVLFKTANGSGWGVRAATALRKGEFVCEYIGEIITSDEANERGK 522
            ..|||..||.||:||.|.:|.|.|::||. .||||||...:.:|.|:|||:||:|:..||:.|
  Rat  1082 QACSCWRSCKNRVVQSGIKVRLQLYRTAK-MGWGVRALQTIPQGTFICEYVGELISDAEADVR-- 1143

  Fly   523 AYDDNGRTYLFDLDYNTAQDSE-YTIDAANYGNISHFINHSCDPNLAVFPCWIEHLNVALPHLVF 586
             .||   :||||||   .:|.| |.|||..|||||.||||.||||:.....::.|.::..|.:.|
  Rat  1144 -EDD---SYLFDLD---NKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAF 1201

  Fly   587 FTLRPIKAGEELSFDYIRADN-EDVPYENLSTAVRVECRCGADNCR 631
            |:.|.|:.||||.|||  .|. .|:..:..:      |:||::.|:
  Rat  1202 FSSRDIRTGEELGFDY--GDRFWDIKSKYFT------CQCGSEKCK 1239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-9	NP_524357.2	P-loop_NTPase	41..>80	CDD:304359	3/10 (30%)
		CHROMO	217..268	CDD:237991	9/54 (17%)
		PreSET	362..455	CDD:128744	19/102 (19%)
		SET	477..609	CDD:214614	63/133 (47%)
Ehmt2	XP_006256016.2	PHA03247	<5..258	CDD:223021
		EHMT_ZBD	473..602	CDD:411018
		Ank_2	717..804	CDD:403870	17/81 (21%)
		ANK repeat	749..778	CDD:293786	4/28 (14%)
		Ank_2	785..878	CDD:403870	21/104 (20%)
		ANK repeat	813..845	CDD:293786	5/31 (16%)
		ANK repeat	848..878	CDD:293786	10/40 (25%)
		Ank_2	852..944	CDD:403870	24/144 (17%)
		ANK repeat	880..911	CDD:293786	5/37 (14%)
		ANK repeat	913..944	CDD:293786	9/65 (14%)
		SET_EHMT2	1011..1249	CDD:380931	96/256 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D753093at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820