DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(var)3-9 and Set1

DIOPT Version :9

Sequence 1:	NP_524357.2	Gene:	Su(var)3-9 / 41483	FlyBaseID:	FBgn0263755	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_001015221.1	Gene:	Set1 / 3354971	FlyBaseID:	FBgn0040022	Length:	1641	Species:	Drosophila melanogaster

Alignment Length:	729	Identity:	153/729 - (20%)
Similarity:	269/729 - (36%)	Gaps:	203/729 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LQKQDLSNLDVSKLTPLSPEVISRQATINIGTIGHVAHGKSTVVKAISGVQTVRFKNELERNIT- 77
            |:::::|.:    |:.|  |.||:.:.|.:...|.    :.|:::.|.  .|.:...|..|::|
  Fly  1007 LKEKNISTI----LSDL--EEISKDSCIGLDENGI----EPTILRKIP--NTPKLNEECRRSLTP 1059

  Fly    78 IKLERLSEKKIKNLLTSKQ--------------QRQQYEIKQRSMLRHLAELRR------HSRFR 122
            :.....:|::||..:..||              :.::|:.:::....::|::.|      ..|..
  Fly  1060 VPPPGYNEEEIKKKVDCKQKPSFEYDRIYSDSEEEKEYQERRKRNTEYMAQMEREFLEEQEKRIE 1124

  Fly   123 RLCTKPASSSMPASTSSVDRRTTRRSTSQTSLSPSNSSGYGSV-------------------FG- 167
            :...|...|......::...|.....|.:|::|.:.|. :.|.                   ||
  Fly  1125 KSLDKNLQSPNNIVKNNNSPRNKNDETRKTAISQTRSC-FESASKVDTTLVNIISVENDINEFGP 1188

  Fly   168 CEEHDV-----DKIPSLNGFAKLKRRRSSCV--GAPTPNSKRSKNNMGVIAKRPPK----GEYVV 221
            .||.||     :|:.: |...|.||.:|...  |..:..|:.|:..:......||.    |:|..
  Fly  1189 HEEGDVLTNGCNKMYT-NSKGKTKRTQSPVYSEGGSSQASQASQVALEHCYSLPPHSVSLGDYPS 1252

  Fly   222 ERIECVEMDQYQPVFFVKWLGYHDSENTWESLA-NVADCAEMEKFVERHQQLYEIYIAKITTELE 285
            .::                   ::::|..:..| |:|..::|.:......:...|.|.|
  Fly  1253 GKV-------------------NETKNILKREAENIAIVSQMTRTGPGRPRKDPICIQK------ 1292

  Fly   286 KQLEALPLMENI---TVAEVDAYEPL-NLQIDLILLAQYRAAGSRSQREPQKIGERAL-KSMQIK 345
            |:.:..|.|.|:   .....|.:..| :..:..:....|:   :|.|.|...|....| |.:..:
  Fly  1293 KKRDLAPRMSNVKSKMTPNGDEWPDLAHKNVHFVPCDMYK---TRDQNEEMVILYTFLTKGIDAE 1354

  Fly   346 RAQFVRRKQLADLALFEKRMNHVEKPSPPIRVENN---IDLDTIDSNFMYIHDNIIGKDVPKPEA 407
            ...|::...|          :|:.| .|.....||   :|..|.|..|.           |.|..
  Fly  1355 DINFIKMSYL----------DHLHK-EPYAMFLNNTHWVDHCTTDRAFW-----------PPPSK 1397

  Fly   408 GIVGCKCTEDTEECTASTKCCARFAG--ELFAYERSTRRLRLRPGSAIYECNSRCSCDSSC---- 466
                 |..:|.|.....|. |||..|  :|...|::..:......:.....|...|.:.:.
  Fly  1398 -----KRRKDDELIRHKTG-CARTEGFYKLDVREKAKHKYHYAKANTEDSFNEDRSDEPTALTNH 1456

  Fly   467 -SNRLVQ---------HGRQVPLVLFKTANGS---------------------------GWGVRA 494
             .|:|:.         ...|..|:   ||.||                           .||:.|
  Fly  1457 HHNKLISKMQGISREARSNQRRLL---TAFGSMGESELLKFNQLKFRKKQLKFAKSAIHDWGLFA 1518

  Fly   495 ATALRKGEFVCEYIGEIITSDEANERGKAYD--DNGRTYLFDLDYNTAQDSEYTIDAANYGNISH 557
            ...:...|.|.||:|::|....|:.|...|:  ..|.:|||.:|..|      .|||...||::.
  Fly  1519 MEPIAADEMVIEYVGQMIRPVVADLRETKYEAIGIGSSYLFRIDMET------IIDATKCGNLAR 1577

  Fly   558 FINHSCDPNLAVFPCWIEHLNV-ALPHLVFFTLRPIKAGEELSFDY-IRADNEDVPYENLSTAVR 620
            ||||||:||     |:.:.:.: :...:|.::.:||...||:::|| ...::|.:|
  Fly  1578 FINHSCNPN-----CYAKVITIESEKKIVIYSKQPIGINEEITYDYKFPLEDEKIP--------- 1628

  Fly   621 VECRCGADNCRKVL 634
              |.|||..||..|
  Fly  1629 --CLCGAQGCRGTL 1640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-9	NP_524357.2	P-loop_NTPase	41..>80	CDD:304359	8/39 (21%)
		CHROMO	217..268	CDD:237991	7/51 (14%)
		PreSET	362..455	CDD:128744	21/97 (22%)
		SET	477..609	CDD:214614	44/162 (27%)
Set1	NP_001015221.1	RRM_Set1	99..191	CDD:240750
		DUF1777	255..>380	CDD:285811
		PRP38_assoc	<318..388	CDD:289628
		N-SET	1341..1492	CDD:288597	36/181 (20%)
		SET	<1463..1641	CDD:225491	54/203 (27%)
		SET	1504..1625	CDD:214614	39/131 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467617
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840