DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(var)3-9 and Set2

DIOPT Version :9

Sequence 1:	NP_524357.2	Gene:	Su(var)3-9 / 41483	FlyBaseID:	FBgn0263755	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_572888.2	Gene:	Set2 / 32301	FlyBaseID:	FBgn0030486	Length:	2362	Species:	Drosophila melanogaster

Alignment Length:	698	Identity:	171/698 - (24%)
Similarity:	258/698 - (36%)	Gaps:	183/698 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 KAISGVQ--TVRFKNELERNITIKLERLSEKKIKNLLTSKQQRQQYEIK-------QRSMLRHLA 113
            ||:||..  ...||.....|..::|:..::||:|.:.|..:...:.|..       |:..|....
  Fly   909 KAVSGFVECDAMFKAMDLANAQLRLDEKNKKKLKKVPTKVEAPPKVEPPTAVPVPGQKKSLSGKT 973

  Fly   114 ELRRHSRFR-----RLCTKPASSSMPASTSS-------VDRR-TTRRST----------SQTSLS 155
            .|||::.:.     ...:.|:|.|..|:||:       |.:: ..||||          |.:|.:
  Fly   974 SLRRNTVYEDSPNLERNSSPSSDSAQANTSAGKLKPSKVKKKINPRRSTICEAAKDLRSSSSSST 1038

  Fly   156 PSNSSGYGSVFGCEEHDVDK-------IPSLNGFAKLKRRR-SSC------VGAPTPNSKRSKNN 206
            |:......|..........|       ...|:|.:||.:|| :.|      ...|.|.:|| :.:
  Fly  1039 PTREVAASSPVSTSSDSSSKRNGSKRTTSDLDGGSKLDQRRYTICEDRQPETAIPVPLTKR-RFS 1102

  Fly   207 MGVIAKRPP----------------KGEYVVERIECVE----MDQYQP---------VFFVKWLG 242
            |...|...|                :|:..:.|...::    ..|..|         :.....|.
  Fly  1103 MHPKASANPLHDTLLQTAGKKRGRKEGKESLSRQNSLDSSSSASQGAPKKKALKSAEILSAALLE 1167

  Fly   243 YHDSENT--------WESLANVADCAEME---------KFVERHQQLYEIYIAKITTELEKQ--- 287
            ...||:|        |:    |....|:|         ||:|....|  :...|:..:..|:
  Fly  1168 TESSESTSSGSKMSRWD----VQTSPELEAANPFGDIAKFIEDGVNL--LKRDKVDEDQRKEGQD 1226

  Fly   288 ---LEALP----LMENITVAEVDAYEPL---------NLQIDLILLAQYRAAGS--RSQREPQK- 333
               .||.|    ..:.:...|..|..|.         :......:|.:....|.  ||.|..||
  Fly  1227 EVKREADPEEDEFAQRVANMETPATTPTPSPTQSNPEDSASTTTVLKELETGGGVRRSHRIKQKP 1291

  Fly   334 IGERALKS---MQIKRAQFVRRKQLADLALFEKRMNHVEKPSPPIRVENNIDLDTIDSNFMYIHD 395
            .|.||.:.   ..:..|.....:|||:||..|......      :|.|.   |:|    |..:.:
  Fly  1292 QGPRASQGRGVASVALAPISMDEQLAELANIEAINEQF------LRSEG---LNT----FQLLKE 1343

  Fly   396 NIIGKDVPKPEAGIVGCKCTEDTEECTASTKCCARFAGELFAYERSTRRLRLRPG----SAIYEC 456
            |..              :|.....:..|..:|.....|:    |.:...|....|    ..:.||
  Fly  1344 NFY--------------RCARQVSQENAEMQCDCFLTGD----EEAQGHLSCGAGCINRMLMIEC 1390

  Fly   457 NSRCSCDSSCSNRLVQHGRQVPLVLFKTANGSGWGVRAATALRKGEFVCEYIGEIITSDEANERG 521
            ...||..:.|:|:..|..:..|..:|:|.. .|.|:.|...:..|||:.||:||:|.|:|...|.
  Fly  1391 GPLCSNGARCTNKRFQQHQCWPCRVFRTEK-KGCGITAELLIPPGEFIMEYVGEVIDSEEFERRQ 1454

  Fly   522 KAYD-DNGRTYLFDLDYNTAQDSEYTIDAANYGNISHFINHSCDPNLAVFPCWIEHLNVALPHLV 585
            ..|. |..|.|.|     .|...|..|||.:.||||.:|||||||| |....|.  :|..| .:.
  Fly  1455 HLYSKDRNRHYYF-----MALRGEAVIDATSKGNISRYINHSCDPN-AETQKWT--VNGEL-RIG 1510

  Fly   586 FFTLRPIKAGEELSFD--YIRADNEDVPYENLSTAVRVECRCGADNCR 631
            ||:::||:.|||::||  |:|...:         |.|  |.|.|.|||
  Fly  1511 FFSVKPIQPGEEITFDYQYLRYGRD---------AQR--CYCEAANCR 1547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-9	NP_524357.2	P-loop_NTPase	41..>80	CDD:304359	7/23 (30%)
		CHROMO	217..268	CDD:237991	14/80 (18%)
		PreSET	362..455	CDD:128744	14/96 (15%)
		SET	477..609	CDD:214614	54/134 (40%)
Set2	NP_572888.2	AWS	1358..1410	CDD:197795	12/55 (22%)
		SET	1414..1533	CDD:214614	53/128 (41%)
		PostSET	1535..1551	CDD:214703	8/24 (33%)
		WW	2014..2043	CDD:278809
		SRI	2270..2348	CDD:285448
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467612
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840