DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(var)3-9 and Suv39h1l1

DIOPT Version :9

Sequence 1:	NP_524357.2	Gene:	Su(var)3-9 / 41483	FlyBaseID:	FBgn0263755	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_001100426.1	Gene:	Suv39h1l1 / 302553	RGDID:	1565028	Length:	413	Species:	Rattus norvegicus

Alignment Length:	494	Identity:	169/494 - (34%)
Similarity:	243/494 - (49%)	Gaps:	101/494 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 GYGSVFGCE---EHDVDKIPSLNGFAKLKRRRSSCVGAPTPNSKRSKNNMGVIAKRPPKGEYVVE 222
            |..:..||.   :...:::..|...|||     ||     |....||.|:         .::.||
  Rat     2 GEPATLGCSVCCKSSWNQLQDLCRLAKL-----SC-----PALGVSKKNL---------YDFEVE 47

  Fly   223 RIECVEMDQYQPVFFVKWLGYHDSENTWESLANVADCAEMEKFVERHQQLYEIYIAKITTELEKQ 287
            .:...:..:.|..:.|||.||.|||||||...|:       |.|...:|.::        :||::
  Rat    48 YLCDYKKIREQEYYLVKWRGYPDSENTWEPRQNL-------KCVRILKQFHK--------DLERE 97

  Fly   288 LEALPLMENITVAEVDAYEPLNLQIDLILLAQYRAAGSRSQREPQKIGERALKSMQIKRAQFVRR 352
                                        |:.::|.:......:|.      |.:..:::|
  Rat    98 ----------------------------LVRRHRRSKPPRHLDPN------LANYLVQKA----- 123

  Fly   353 KQLADLALFEKRMNHVEKPSPPIRVENNIDLDTIDSNFMYIHDNIIGKDVPKPEAGIVGCKCTED 417
            ||...|..:|:.:|........|.|||.:|||....:|:||::..:|:.:...:.. |||:|
  Rat   124 KQRRALQRWEQELNAKRSHLGRITVENEVDLDGPPRSFVYINEYRVGEGITLNQVA-VGCEC--- 184

  Fly   418 TEECTASTK--CCARFAGELFAYERSTRRLRLRPGSAIYECNSRCSCDSSCSNRLVQHGRQVPLV 480
             ::|..:..  ||...:...||| ....::||:.|..||||||||.|...|.||:||.|.:..|.
  Rat   185 -QDCLLAPTGGCCPGASLHKFAY-NDQGQVRLKAGQPIYECNSRCCCGYDCPNRVVQKGIRYNLC 247

  Fly   481 LFKTANGSGWGVRAATALRKGEFVCEYIGEIITSDEANERGKAYDDNGRTYLFDLDYNTAQDSEY 545
            :|:|.:|.|||||....:||..||.||:||||||:||..||:.||..|.||||||||   .:..|
  Rat   248 IFRTDDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDY---VEDVY 309

  Fly   546 TIDAANYGNISHFINHSCDPNLAVFPCWIEHLNVALPHLVFFTLRPIKAGEELSFDY-IRADNED 609
            |:|||.|||||||:||||||||.|:..:|::|:..||.:.||..|.|.|||||:||| ::.|..|
  Rat   310 TVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIWAGEELTFDYNMQVDPVD 374

  Fly   610 VPYENLST-------------AVRVECRCGADNCRKVLF 635
            :....:.:             .||:||:||...|||.||
  Rat   375 MESTRMDSNFGLAGLPGSPKKRVRIECKCGTTACRKYLF 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-9	NP_524357.2	P-loop_NTPase	41..>80	CDD:304359
		CHROMO	217..268	CDD:237991	18/50 (36%)
		PreSET	362..455	CDD:128744	27/94 (29%)
		SET	477..609	CDD:214614	74/132 (56%)
Suv39h1l1	NP_001100426.1	Chromo	45..92	CDD:278797	19/53 (36%)
		PreSET	133..228	CDD:128744	33/100 (33%)
		SET	244..367	CDD:214614	72/125 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337081
Domainoid	1	1.000	148	1.000	Domainoid score	I4345
eggNOG	1	0.900	-	-		E2759_KOG1082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	256	1.000	Inparanoid score	I3083
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D589939at33208
OrthoFinder	1	1.000	-	-		FOG0001837
OrthoInspector	1	1.000	-	-		otm45878
orthoMCL	1	0.900	-	-		OOG6_100876
Panther	1	1.100	-	-	LDO	PTHR46223
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X219
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.800