DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(var)3-9 and clr4

DIOPT Version :9

Sequence 1:	NP_524357.2	Gene:	Su(var)3-9 / 41483	FlyBaseID:	FBgn0263755	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_595186.1	Gene:	clr4 / 2540825	PomBaseID:	SPBC428.08c	Length:	490	Species:	Schizosaccharomyces pombe

Alignment Length:	520	Identity:	151/520 - (29%)
Similarity:	229/520 - (44%)	Gaps:	131/520 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 PPKGEYVVERIECVEMDQYQPV--FFVKWLGYHDSENTWESLANVADCA---------------- 260
            |.:.||.||||...::|:...|  :.::||.|....:|||...|::.|:
pombe     3 PKQEEYEVERIVDEKLDRNGAVKLYRIRWLNYSSRSDTWEPPENLSGCSAVLAEWKRRKRRLKGS 67

  Fly   261 -----------------------EMEKFVERHQQL-YEIYIAK--------ITTELEKQLEALPL 293
                                   :..|.|.|.|:. .|:.:.|        .||:.:.:.::..|
pombe    68 NSDSDSPHHASNPHPNSRQKHQHQTSKSVPRSQRFSRELNVKKENKKVFSSQTTKRQSRKQSTAL 132

  Fly   294 MENITVAEVDAYEPLNLQIDLILLAQYRAAGSRSQREPQKIGERALKSMQIKRA----------- 347
            ..|.|          ::.:|..|....:..|.......::..:|.|.|..||.|
pombe   133 TTNDT----------SIILDDSLHTNSKKLGKTRNEVKEESQKRELVSNSIKEATSPKTSSILTK 187

  Fly   348 -------------QFVRRKQLADLALFEKRMNHVEKPSPPIRVENNIDLDTIDS-NFMYIHDNII 398
                         .|..:::     ||.|::..:|  .|.:.:.|.:|.:...| :|.:|....:
pombe   188 PRNPSKLDSYTHLSFYEKRE-----LFRKKLREIE--GPEVTLVNEVDDEPCPSLDFQFISQYRL 245

  Fly   399 GKDVPKPEAGIVG-----------------CKCTEDTEECTASTKCCARFAGELFAYERSTRRLR 446
            .:.|..|:.....                 |:|.:|.:|.|.            |||: :..|:|
pombe   246 TQGVIPPDPNFQSGCNCSSLGGCDLNNPSRCECLDDLDEPTH------------FAYD-AQGRVR 297

  Fly   447 LRPGSAIYECNSRCSCDSSCSNRLVQHGRQVPLVLFKTANGSGWGVRAATALRKGEFVCEYIGEI 511
            ...|:.||||||.|||...|.||:||.||.:||.:|||.. .|||||:......|.|:..|:||:
pombe   298 ADTGAVIYECNSFCSCSMECPNRVVQRGRTLPLEIFKTKE-KGWGVRSLRFAPAGTFITCYLGEV 361

  Fly   512 ITSDEANERGKAYDDNGRTYLFDLD-YNTAQDSEYTIDAANYGNISHFINHSCDPNLAVFPCWIE 575
            |||.||.:|.|.|||:|.||||||| ::.|  ||||:||.|||::|.|.||||.||:|::.....
pombe   362 ITSAEAAKRDKNYDDDGITYLFDLDMFDDA--SEYTVDAQNYGDVSRFFNHSCSPNIAIYSAVRN 424

  Fly   576 HLNVALPHLVFFTLRPIKAGEELSFDYIRADN-----EDVPYENLSTAVRVECRCGADNCRKVLF 635
            |....:..|.||.::.|:..|||:|||..|.:     .....:|..:.:|.:|:||:.|||..||
pombe   425 HGFRTIYDLAFFAIKDIQPLEELTFDYAGAKDFSPVQSQKSQQNRISKLRRQCKCGSANCRGWLF 489

Fly 636 635
pombe 490 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-9	NP_524357.2	P-loop_NTPase	41..>80	CDD:304359
		CHROMO	217..268	CDD:237991	18/91 (20%)
		PreSET	362..455	CDD:128744	22/110 (20%)
		SET	477..609	CDD:214614	64/137 (47%)
clr4	NP_595186.1	SET	1..489	CDD:225491	149/518 (29%)
		CHROMO	7..62	CDD:214605	16/54 (30%)
		PreSET	209..312	CDD:128744	28/117 (24%)
		SET	329..451	CDD:214614	61/124 (49%)
		PostSET	474..489	CDD:214703	7/14 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	115	1.000	Domainoid score	I1532
eggNOG	1	0.900	-	-		E2759_KOG1082
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H119873
Inparanoid	1	1.050	190	1.000	Inparanoid score	I1059
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001837
OrthoInspector	1	1.000	-	-		oto101646
orthoMCL	1	0.900	-	-		OOG6_100876
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R211
SonicParanoid	1	1.000	-	-		X219
TreeFam	1	0.960	-	-
	12	11.750