Protein Alignment Su(var)3-9 and EZH2

DIOPT Version :10

• Sequence 1: NP_524357.2
• Gene: Su(var)3-9 / 41483
• FlyBaseID: FBgn0263755
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: XP_011514185.1
• Gene: EZH2 / 2146
• HGNCID: 3527
• Length: 759
• Species: Homo sapiens
• Alignment Length: 541
• Identity: 114/541 - (21%)
• Similarity: 193/541 - (35%)
• Gaps: 183/541 - (33%)

  Fly   116 RRHSRFRRLCTKPASSSMPASTS-----SVDRRTTRRSTSQTSLSPSNSSGYGSVFGCEEHDVDK 175
            ||..|.      |.:||.|::.:     |.|..:.|.:.::|              |.|.:|.::
Human   366 RRRGRL------PNNSSRPSTPTINVLESKDTDSDREAGTET--------------GGENNDKEE 410

  Fly   176 IPSLNGFAKLKRRRSSCVGAPTPNSKRSKNNMGVIAKRPPKGEYVVERIECVEMDQYQPVFFVKW 240
                      :.::.....:...||:         .:.|.|.:..:|..|.||....:...|...
Human   411 ----------EEKKDETSSSSEANSR---------CQTPIKMKPNIEPPENVEWSGAEASMFRVL 456

  Fly   241 LG-YHDSENTWESLANVADCAEMEKFVERHQQLYEIYIAKITTELEKQLEALPLMENITVAEVDA 304
            :| |:|:......|.....|          :|:||..:                .|:..:|...|
Human   457 IGTYYDNFCAIARLIGTKTC----------RQVYEFRV----------------KESSIIAPAPA 495

  Fly   305 YEPLNLQIDLILLAQYRAAGSRSQREPQKIGERALKSMQIKRAQFVRRKQLADLALFEKRMNHVE 369
            .:     :|         ...|.::...::.....:.:|:|:               :...|||.
Human   496 ED-----VD---------TPPRKKKRKHRLWAAHCRKIQLKK---------------DGSSNHVY 531

  Fly   370 KPSPPIRVENNIDLD---TIDSNFMYIHDNIIGKDVPKPEAGIVGCKCTEDTEECTASTKCCARF 431
            ...|........|..   .|..||                     |:     :.|..|::|..||
Human   532 NYQPCDHPRQPCDSSCPCVIAQNF---------------------CE-----KFCQCSSECQNRF 570

  Fly   432 AGELFAYERSTRRLRLRPGSAIYECNSR-CSC---------------------DS---SCSNRLV 471
            .|           .|.:.     :||:: |.|                     ||   ||.|..:
Human   571 PG-----------CRCKA-----QCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSI 619

  Fly   472 QHGRQVPLVLFKTANGSGWGVRAATALRKGEFVCEYIGEIITSDEANERGKAYDDNGRTYLFDLD 536
            |.|.:..|:| ..::.:|||:.....::|.||:.||.||||:.|||:.|||.||....::||:|
Human   620 QRGSKKHLLL-APSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNL- 682

  Fly   537 YNTAQDSEYTIDAANYGNISHFINHSCDPNLAVFPCWIEHLNVALPHLV-FFTLRPIKAGEELSF 600
                 ::::.:||...||...|.|||.:||     |:.:.:.|...|.: .|..|.|:.||||.|
Human   683 -----NNDFVVDATRKGNKIRFANHSVNPN-----CYAKVMMVNGDHRIGIFAKRAIQTGEELFF 737

  Fly   601 DYIRADNEDVPYENLSTAVRV 621
            ||..:..:.:.|..:...:.:
Human   738 DYRYSQADALKYVGIEREMEI 758

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-9	NP_524357.2	PTZ00327	11..>80	CDD:240362
		Chromo	219..268	CDD:459793	10/49 (20%)
		SET_SUV39H	388..634	CDD:380940	70/260 (27%)
EZH2	XP_011514185.1	EZH2_WD-Binding	47..76	CDD:463308
		PRC2_HTH_1	166..257	CDD:436286
		preSET_CXC	572..603	CDD:408079	6/46 (13%)
		SET_EZH2	622..741	CDD:380995	49/130 (38%)