Protein Alignment Su(var)3-9 and Kmt2a

DIOPT Version :10

• Sequence 1: NP_524357.2
• Gene: Su(var)3-9 / 41483
• FlyBaseID: FBgn0263755
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: NP_001344478.1
• Gene: Kmt2a / 214162
• MGIID: 96995
• Length: 3966
• Species: Mus musculus
• Alignment Length: 605
• Identity: 136/605 - (22%)
• Similarity: 215/605 - (35%)
• Gaps: 164/605 - (27%)

  Fly    92 LTSKQQRQQYEI--KQRSMLRHLAELRRHSRFRRLCT----KPASSSMPASTSSVDRRTTRRS-- 148
            |||::.|.....  .|.|.....||.....|..:..|    |||||:.|.|:.|..:::...|
Mouse  3463 LTSQRDRDPDSAPGTQPSNFTQTAEAPNGVRLEQNKTLPSAKPASSASPGSSPSSGQQSGSSSVP 3527

  Fly   149 --------TSQTSLSPSNSSGYGSVFGCEEHDVDKI------------------PSLNGFAKLKR 187
                    ..:..|.....||       ::|.|..:                  ||:....:..|
Mouse  3528 GPTKPKPKAKRIQLPLDKGSG-------KKHKVSHLRTSSEAHIPHRDTDPAPQPSVTRTPRANR 3585

  Fly   188 RRSSCVGAPTPNSKRSKNNMGVIAKRP-------PKGEYVVERIECVEMDQYQPVF---FVKWLG 242
            .:....|...|:.|......|.:|..|       |..|.  |..|...|::.:..|   .:.||
Mouse  3586 EQQDAAGVEQPSQKECGQPAGPVAALPEVQATQNPANEQ--ENAEPKAMEEEESGFSSPLMLWL- 3647

  Fly   243 YHDSENTWESLAN-------VADCAEMEKFVERHQQLYEIYIAKITTELEKQLEALPLMENITVA 300
             ...:...||:..       |.:.:..:.|....:.:.:.:  |..|:..::..:...::.::.|
Mouse  3648 -QQEQKRKESITERKPKKGLVFEISSDDGFQICAESIEDAW--KSLTDKVQEARSNARLKQLSFA 3709

  Fly   301 EVDAYEPLNLQIDLILLAQYRAAGSRSQR-------EPQKIGERALKSMQIKRAQFVRRKQLADL 358
            .|:....|.:..|.::....:.||::..|       :|::..|..|......||:...||...|:
Mouse  3710 GVNGLRMLGILHDAVVFLIEQLAGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDM 3774

  Fly   359 ALFEKRMNHVEKP--SPPIRVENNIDLDTIDSNFMYIHDNIIGKDVPKPEAGIVGCKCTEDTEEC 421
            ..| ....|.:.|  :|....|..:.|.:.        ......|:|.|
Mouse  3775 FNF-LASKHRQPPEYNPNDEEEEEVQLKSA--------RRATSMDLPMP---------------- 3814

  Fly   422 TASTKCCARFAGELFAYERSTRRLRLRPGSAIYECNSRCSCDSSCSNRLVQHGRQVPLVLFKTAN 486
                   .||           |.|:.....|:....|..            |||
Mouse  3815 -------MRF-----------RHLKKTSKEAVGVYRSPI------------HGR----------- 3838

  Fly   487 GSGWGVRAATALRKGEFVCEYIGEIITSDEANERGKAYDDNG-RTYLFDLDYNTAQDSEYTIDAA 550
                |:.....:..||.|.||.|.:|.|.:.::|.|.||..| ..|:|.:|     ||| .:||.
Mouse  3839 ----GLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRID-----DSE-VVDAT 3893

  Fly   551 NYGNISHFINHSCDPNLAVFPCWIEHLNV-ALPHLVFFTLRPIKAGEELSFDYIRADNEDVPYEN 614
            .:||.:.||||||:||     |:...:|: ...|:|.|.:|.|..||||::||      ..|.|:
Mouse  3894 MHGNAARFINHSCEPN-----CYSRVINIDGQKHIVIFAMRKIYRGEELTYDY------KFPIED 3947

  Fly   615 LSTAVRVECRCGADNCRKVL 634
            .|.  ::.|.|||..|||.|
Mouse  3948 ASN--KLPCNCGAKKCRKFL 3965

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-9	NP_524357.2	PTZ00327	11..>80	CDD:240362
		Chromo	219..268	CDD:459793	10/58 (17%)
		SET_SUV39H	388..634	CDD:380940	67/247 (27%)
Kmt2a	NP_001344478.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..106
		Menin-binding motif (MBM). /evidence=ECO:0000250|UniProtKB:Q03164	6..25
		Integrase domain-binding motif 1 (IBM1). /evidence=ECO:0000250|UniProtKB:Q03164	121..132
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	130..231
		Integrase domain-binding motif 2 (IBM2). /evidence=ECO:0000250|UniProtKB:Q03164	145..150
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	322..343
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	440..590
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	711..943
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	963..1003
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1034..1064
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1101..1161
		zf-CXXC	1144..1191	CDD:366873
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1196..1390
		PHD1_KMT2A	1432..1478	CDD:277063
		PHD2_KMT2A	1480..1529	CDD:277065
		PHD3_KMT2A	1567..1626	CDD:277067
		Interaction with histone H3K4me3. /evidence=ECO:0000250|UniProtKB:Q03164	1583..1599
		Bromo_ALL-1	1649..1779	CDD:99925
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1665..1714
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1807..1870
		ePHD_KMT2A	1873..1985	CDD:277163
		FYRN	2026..2073	CDD:461787
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2147..2174
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2214..2339
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2371..2619
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2639..2673
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2709..2759
		9aaTAD. /evidence=ECO:0000250|UniProtKB:Q03164	2843..2851
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2958..3060
		Herpes_BLLF1	<3152..>3361	CDD:282904
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3164..3239
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3462..3640		38/185 (21%)
		FYRC	3666..3749	CDD:197781	12/84 (14%)
		WDR5 interaction motif (WIN). /evidence=ECO:0000250|UniProtKB:Q03164	3759..3764		1/4 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3782..3805		5/30 (17%)
		SET_KMT2A_2B	3813..3966	CDD:380947	66/233 (28%)