DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(var)3-9 and ehmt1

DIOPT Version :9

Sequence 1:	NP_524357.2	Gene:	Su(var)3-9 / 41483	FlyBaseID:	FBgn0263755	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	XP_031762692.1	Gene:	ehmt1 / 100124713	XenbaseID:	XB-GENE-5793917	Length:	1277	Species:	Xenopus tropicalis

Alignment Length:	692	Identity:	176/692 - (25%)
Similarity:	281/692 - (40%)	Gaps:	183/692 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 KQDLSNLDVSKLTPLSPEVISRQATINIGTIGHVAHG--KSTVVKAISGVQTVRFKNELERNITI 78
            ||:.:    |.|...:||.|.   |.::|....::.|  |.|:..|:                 :
Frog   664 KQEAT----SSLPGGTPEPIE---TPSLGKPPSLSQGPVKETLESAL-----------------L 704

  Fly    79 KLERLSEKKI----KNLLTSKQQRQ--------------QYEIKQ---RSMLRHLAELRRHSRFR 122
            .|:....||:    |.|..|.:|.:              .|:::|   |:.|...||:    .:.
Frog   705 ALDSEKPKKLRFHPKQLYFSARQGELQKVLMMLVDGIDPNYKMEQHSRRTPLHAAAEM----GYT 765

  Fly   123 RLCTKPASSSMPASTSSVDRRTTRRSTSQTSLSPSNSSGYGSVFGCEEHDVDKIPSL-NGFAKLK 186
            .:|.....:.....:.|.|:||.....:                  |.:.:|.:..| .|.|.:
Frog   766 DICHMLIQAGANLDSCSEDQRTPLMEAA------------------ENNHLDTVKYLVKGGALI- 811

  Fly   187 RRRSSCVGAPTPNSKRSKNNMGVIAKRPPKGEYVV-------ER--IEC---------VEMDQYQ 233
                      .|........:.:.||   ||.|.|       ||  :.|         :...:|:
Frog   812 ----------DPKDSEGSTCLHLAAK---KGHYEVVKYLLSSERTDVNCQDDGGWTPMIWATEYK 863

  Fly   234 PVFFVKWLGYHDSE---NTWESLANVADCAEMEKFVERHQQLYEIYIAKITTELEKQLEALPLME 295
            .|..||.|  |.|.   |..::..|:  |.....|..      .:.||:|....:..|.|:
Frog   864 HVEIVKLL--HSSRADVNIRDNEENI--CLHWAAFAG------SVEIAEILLASKCDLRAV---- 914

  Fly   296 NITVAEVDAYEPLNL-------QIDLILLAQYRAAGSRSQREPQKIGERALKS--------MQIK 345
                 .:....||::       :..::.|......|.::     |.||..|:.        ..:.
Frog   915 -----NIHGDSPLHIAARENRHECVMLFLGHGSEVGLKN-----KEGETPLECSAPNSDVWAALS 969

  Fly   346 RAQFVRRKQLADLALFEKRMN--HVEKPSPPIRVENNIDLDTIDSNFMYIHDNIIGK--DVPKPE 406
            :.|.:..|......:.::.::  :...|.|.:..|   |.:....|:.|:..|.:..  ::.:..
Frog   970 KCQALPEKPTLQEKVVDRDISRGYENIPIPCVNAE---DSELCPVNYKYVSQNCVTSPLNIDRNI 1031

  Fly   407 AGIVGCKCTEDTEECTASTKCCARFAGELFAYERSTRRL----RLRPGSAIYECNSRCSCDSSCS 467
            ..:..|.|.:|   |::|...|.:.:...: |:::.|.|    .|.| ..|:|||..|||..:|.
Frog  1032 THLQYCVCIDD---CSSSNCMCGQLSMRCW-YDKNGRLLPEFNMLEP-PLIFECNHACSCWRNCR 1091

  Fly   468 NRLVQHGRQVPLVLFKTANGSGWGVRAATALRKGEFVCEYIGEIITSDEANERGKAYDDNGRTYL 532
            ||:||:|.::.|.||:| ...|||||:...:.:|.|||||:||:|:..||:.|   .||   |||
Frog  1092 NRVVQNGLKIRLQLFRT-KSKGWGVRSLQDIPQGTFVCEYVGELISDAEADVR---EDD---TYL 1149

  Fly   533 FDLDYNTAQDSE-YTIDAANYGNISHFINHSCDPNLAVFPCWIEHLNVALPHLVFFTLRPIKAGE 596
            ||||   .:|.| |.|||..|||||.||||.|:|||.....::.|.::..|.:.||:.|.|.|||
Frog  1150 FDLD---NKDREVYCIDARFYGNISRFINHLCEPNLLPVRVFMSHQDLRFPRIGFFSSRHIGAGE 1211

  Fly   597 ELSFDYIRADN-EDVPYENLSTAVRVECRCGADNCR---KVL 634
            |:.|||  .|. .||..:..|      |:||:..|:   |||
Frog  1212 EIGFDY--GDRFWDVKGKLFS------CQCGSPKCKHPIKVL 1245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)3-9	NP_524357.2	P-loop_NTPase	41..>80	CDD:304359	5/40 (13%)
		CHROMO	217..268	CDD:237991	17/71 (24%)
		PreSET	362..455	CDD:128744	19/100 (19%)
		SET	477..609	CDD:214614	63/133 (47%)
ehmt1	XP_031762692.1	EHMT_ZBD	495..622	CDD:411018
		Ank_2	721..815	CDD:403870	20/126 (16%)
		ANK repeat	753..782	CDD:293786	5/32 (16%)
		ANK repeat	784..815	CDD:293786	9/59 (15%)
		Ank_2	789..882	CDD:403870	23/126 (18%)
		ANK repeat	817..849	CDD:293786	9/34 (26%)
		ANK repeat	851..882	CDD:293786	8/32 (25%)
		Ank_2	856..948	CDD:403870	20/110 (18%)
		ANK repeat	884..915	CDD:293786	8/47 (17%)
		ANK repeat	917..948	CDD:293786	4/30 (13%)
		SET_EHMT1	1011..1241	CDD:380933	97/252 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D753093at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010