DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4860 and ACOX3

DIOPT Version :9

Sequence 1:	NP_650163.2	Gene:	CG4860 / 41480	FlyBaseID:	FBgn0037999	Length:	415	Species:	Drosophila melanogaster
Sequence 2:	NP_001362712.1	Gene:	ACOX3 / 8310	HGNCID:	121	Length:	700	Species:	Homo sapiens

Alignment Length:	366	Identity:	88/366 - (24%)
Similarity:	140/366 - (38%)	Gaps:	83/366 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 RRLGELGLMSVTVREEYGGSGLDYQA--YAIGMEEVARGDAAVSIVMGVNNLYLG-AVQQHGTEQ 136
            :|:.|...:||   |:...|.|...|  ..:||.     |::::....:::|..| ||...|:|:
Human    83 KRIFEYDFLSV---EDMFKSPLKVPALIQCLGMY-----DSSLAAKYLLHSLVFGSAVYSSGSER 139

  Fly   137 QKQDFLVPYTQG----EHIAFYALSEPGNGSDAGAASTTAKLQG-------DSYQINGTKAWISN 190
            .     :.|.|.    |....:||:|..:||:..|..|||....       .|......|.|:.|
Human   140 H-----LTYIQKIFRMEIFGCFALTELSHGSNTKAIRTTAHYDPATEEFIIHSPDFEAAKFWVGN 199

  Fly   191 -SKEASGGIVFA--TVDKSMKHKGITAFLT----PK---DVPGLSIAKKESKMGMRATSTCQLVL 245
             .|.|:..:|||  .|.....| |:..|:.    ||   .:||:.:.....|:|.........:.
Human   200 MGKTATHAVVFAKLCVPGDQCH-GLHPFIVQIRDPKTLLPMPGVMVGDIGKKLGQNGLDNGFAMF 263

  Fly   246 EDVHVPRSRVLGAAGD----------------GFKIAMQSLDCGRIGIAAQATGIAQAALELAVD 294
            ..|.|||..:|...||                .|..::.||..||:.|.:.|....:.|:.:|:.
Human   264 HKVRVPRQSLLNRMGDVTPEGTYVSPFKDVRQRFGASLGSLSSGRVSIVSLAILNLKLAVAIALR 328

  Fly   295 YSQKRVAFG--------------------KHLARLQLI----QQKLADMATRVEISRLLTW--RA 333
            :|..|..||                    .:||.:..:    :....|:   ||:.|.|..  |:
Human   329 FSATRRQFGPTEEEEIPVLEYPMQQWRLLPYLAAVYALDHFSKSLFLDL---VELQRGLASGDRS 390

  Fly   334 AWLKDNGLPITKEAAMAKLHASESATFCAHQCIQILGGMGY 374
            |...:.|..|...|:.:|..||.:......:|.:..||.||
Human   391 ARQAELGREIHALASASKPLASWTTQQGIQECREACGGHGY 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4860	NP_650163.2	CaiA	37..414	CDD:224871	88/366 (24%)
CG4860	NP_650163.2	SCAD_SBCAD	39..410	CDD:173847	88/366 (24%)
ACOX3	NP_001362712.1	AXO	19..672	CDD:173839	88/366 (24%)
ACOX3	NP_001362712.1	Microbody targeting signal. /evidence=ECO:0000250\|UniProtKB:Q63448	698..700
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810