DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4860 and ACADSB

DIOPT Version :9

Sequence 1:	NP_650163.2	Gene:	CG4860 / 41480	FlyBaseID:	FBgn0037999	Length:	415	Species:	Drosophila melanogaster
Sequence 2:	NP_001600.1	Gene:	ACADSB / 36	HGNCID:	91	Length:	432	Species:	Homo sapiens

Alignment Length:	423	Identity:	163/423 - (38%)
Similarity:	252/423 - (59%)	Gaps:	18/423 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 QLIRVARTLGQR--------------SSGAWSARIIAGGNRGI--ACLAALSETHQILQKTCREF 51
            :|:|.:|.|.:.              |..:.|..::...|.||  |.|...::...:::.:.::|
Human     7 RLLRGSRLLRRNFLTCLSSWKIPPHVSKSSQSEALLNITNNGIHFAPLQTFTDEEMMIKSSVKKF 71

  Fly    52 ANAELAPKARHHDREELYPAEQVRRLGELGLMSVTVREEYGGSGLDYQAYAIGMEEVARGDAAVS 116
            |..::||.....|.........::.|.:.|||.:.|..||||:|..:.:..:.:||:|:.||:|:
Human    72 AQEQIAPLVSTMDENSKMEKSVIQGLFQQGLMGIEVDPEYGGTGASFLSTVLVIEELAKVDASVA 136

  Fly   117 IVMGVNNLYLGA-VQQHGTEQQKQDFLVPYTQGEHIAFYALSEPGNGSDAGAASTTAKLQGDSYQ 180
            :...:.|..:.. :::||||:||..:| |....|.:..:.|||.|.|||:.|..|.|..:||.|.
Human   137 VFCEIQNTLINTLIRKHGTEEQKATYL-PQLTTEKVGSFCLSEAGAGSDSFALKTRADKEGDYYV 200

  Fly   181 INGTKAWISNSKEASGGIVFATVDKSMKHKGITAFLTPKDVPGLSIAKKESKMGMRATSTCQLVL 245
            :||:|.|||:::.|...:|.|.||.::.:||||:||..:|.|||.|.|.|:|:|:||:|||.|..
Human   201 LNGSKMWISSAEHAGLFLVMANVDPTIGYKGITSFLVDRDTPGLHIGKPENKLGLRASSTCPLTF 265

  Fly   246 EDVHVPRSRVLGAAGDGFKIAMQSLDCGRIGIAAQATGIAQAALELAVDYSQKRVAFGKHLARLQ 310
            |:|.||.:.:||..|.|:|.|:.||:.||||||||..|:||...:..:.|.::|:.|||.|...|
Human   266 ENVKVPEANILGQIGHGYKYAIGSLNEGRIGIAAQMLGLAQGCFDYTIPYIKERIQFGKRLFDFQ 330

  Fly   311 LIQQKLADMATRVEISRLLTWRAAWLKDNGLPITKEAAMAKLHASESATFCAHQCIQILGGMGYT 375
            .:|.::|.:||::|.:||||:.||.|.:.|.|..|||:|||.:|||.|.....:||:.:||:|||
Human   331 GLQHQVAHVATQLEAARLLTYNAARLLEAGKPFIKEASMAKYYASEIAGQTTSKCIEWMGGVGYT 395

  Fly   376 TDLPAELYYRNARVTEIYEGTSEIQRIVIANAV 408
            .|.|.|.|:|:|::..||||.|.||...||..:
Human   396 KDYPVEKYFRDAKIGTIYEGASNIQLNTIAKHI 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4860	NP_650163.2	CaiA	37..414	CDD:224871	152/373 (41%)
CG4860	NP_650163.2	SCAD_SBCAD	39..410	CDD:173847	152/371 (41%)
ACADSB	NP_001600.1	CaiA	57..428	CDD:224871	152/371 (41%)
		SCAD_SBCAD	59..430	CDD:173847	152/371 (41%)
		Substrate binding. /evidence=ECO:0000269\|Ref.15	291..294		0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1951
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D589058at2759
OrthoFinder	1	1.000	-	-		FOG0000508
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102170
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.670