DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4860 and Acadvl

DIOPT Version :9

Sequence 1:	NP_650163.2	Gene:	CG4860 / 41480	FlyBaseID:	FBgn0037999	Length:	415	Species:	Drosophila melanogaster
Sequence 2:	NP_059062.1	Gene:	Acadvl / 11370	MGIID:	895149	Length:	656	Species:	Mus musculus

Alignment Length:	480	Identity:	145/480 - (30%)
Similarity:	225/480 - (46%)	Gaps:	73/480 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 QQLIRVARTLGQRSSGAWSARIIAGGNRGIAC--LAALSETHQILQK---------TCREFANAE 55
            :||:|    ||.|||.  |..::.|..|.|:.  |.|...|..:|.|         |..:.|.||
Mouse    12 RQLLR----LGARSSR--STTVLQGQPRPISAQRLYAREATQAVLDKPETLSSDASTREKPARAE 70

  Fly    56 ------------------------------------LAPKAR---------HHDREELYPAEQVR 75
                                                :.|.||         .:|..|....:.::
Mouse    71 SKSFAVGMFKGQLTIDQVFPYPSVLSEEQAQFLKELVGPVARFFEEVNDPAKNDALEKVEDDTLQ 135

  Fly    76 RLGELGLMSVTVREEYGGSGLDYQAYAIGMEEVARGDAAVSIVMGVN-NLYLGAVQQHGTEQQKQ 139
            .|.|||...:.|..|.||.||....||...|.|...|..||:.:|.: ::....:..:||:.|::
Mouse   136 GLKELGAFGLQVPSELGGLGLSNTQYARLAEIVGMHDLGVSVTLGAHQSIGFKGILLYGTKAQRE 200

  Fly   140 DFLVPYTQGEHIAFYALSEPGNGSDAGAASTTA--KLQGDSYQINGTKAWISNSKEASGGIVFA- 201
            .:|.....|:.:|.:.|:||.:|||..:..::|  ...|..|.:||:|.||||...|....|||
Mouse   201 KYLPRVASGQALAAFCLTEPSSGSDVASIRSSAIPSPCGKYYTLNGSKIWISNGGLADIFTVFAK 265

  Fly   202 -----TVDKSMKHKGITAFLTPKDVPGLSIAKKESKMGMRATSTCQLVLEDVHVPRSRVLGAAGD 261
                 ....::|.| ||||:..:...|::....|.|||::|::|.::..:.|.||...|||..||
Mouse   266 TPIKDAATGAVKEK-ITAFVVERSFGGVTHGLPEKKMGIKASNTSEVYFDGVKVPSENVLGEVGD 329

  Fly   262 GFKIAMQSLDCGRIGIAAQATGIAQAALELAVDYSQKRVAFGKHLARLQLIQQKLADMATRVEIS 326
            |||:|:..|:.||.|:||...|..::.:..|||::..|..||..:....:||:|||.||....::
Mouse   330 GFKVAVNILNNGRFGMAATLAGTMKSLIAKAVDHATNRTQFGDKIHNFGVIQEKLARMAILQYVT 394

  Fly   327 RLLTWRAAWLKDNGL-PITKEAAMAKLHASESATFCAHQCIQILGGMGYTTDLPAELYYRNARVT 390
            ..:.:..:...|.|. ....|||::|:..||:|...|.:||||:||||:..:...|...|:.|:.
Mouse   395 ESMAYMLSANMDQGFKDFQIEAAISKIFCSEAAWKVADECIQIMGGMGFMKEPGVERVLRDIRIF 459

  Fly   391 EIYEGTSEIQRIVIANAVLRELGKE 415
            .|:||.::|.|:.:|.....:.|||
Mouse   460 RIFEGANDILRLFVALQGCMDKGKE 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4860	NP_650163.2	CaiA	37..414	CDD:224871	128/440 (29%)
CG4860	NP_650163.2	SCAD_SBCAD	39..410	CDD:173847	128/434 (29%)
Acadvl	NP_059062.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		10/26 (38%)
		Catalytic. /evidence=ECO:0000250\|UniProtKB:P49748	42..483		129/441 (29%)
		VLCAD	73..482	CDD:173850	121/409 (30%)
		CaiA	95..474	CDD:224871	120/379 (32%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P49748	462..464		0/1 (0%)
		Membrane-anchoring. /evidence=ECO:0000250\|UniProtKB:P49748	484..517		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810