DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cog1 and COG1

DIOPT Version :9

Sequence 1:NP_001262497.1 Gene:Cog1 / 41479 FlyBaseID:FBgn0037998 Length:886 Species:Drosophila melanogaster
Sequence 2:NP_061184.1 Gene:COG1 / 9382 HGNCID:6545 Length:980 Species:Homo sapiens


Alignment Length:1024 Identity:252/1024 - (24%)
Similarity:416/1024 - (40%) Gaps:222/1024 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 LFEQHSVSEIDEVHKKIQSVVENKREELRTHVGERYRDLLQAADTIAAMQTSAGTLMEQVRHVQA 77
            |||.|...||..:.:::::.:|:|:||||..||||||||::|||||..|:..|..|::.|:....
Human    21 LFETHGAEEIRGLERQVRAEIEHKKEELRQMVGERYRDLIEAADTIGQMRRCAVGLVDAVKATDQ 85

  Fly    78 NCRSLNEQQLLGFQSTANASAKDAALKERNAGKKLQTYYGTMAQIKLLTALPELIWTHLDNDRFY 142
            .|..|.:         |.::|......::......:.:|...||||||..:||.||:.::..:..
Human    86 YCARLRQ---------AGSAAPRPPRAQQPQQPSQEKFYSMAAQIKLLLEIPEKIWSSMEASQCL 141

  Fly   143 AATELFIFSRHISTGLQLDGQSA----LMQKLPVARKQWEILRPFHVTIKQAILTALEREELLQE 203
            .||:|::...|:.:.||||..|:    ::.:.|:..:|......|..||.......|:.:.:..:
Human   142 HATQLYLLCCHLHSLLQLDSSSSRYSPVLSRFPILIRQVAAASHFRSTILHESKMLLKCQGVSDQ 206

  Fly   204 MTVDCLQSLLLLDKSDLSTVLKSFLNLRSSAFLNCLQSGPSEPRRVKDRILASLNVLNSTVE--- 265
            ...:.|.|::||::|.....|..|| |...|.:..|.:.|.....:|.:|.:.:.:|.:|::   
Human   207 AVAEALCSIMLLEESSPRQALTDFL-LARKATIQKLLNQPHHGAGIKAQICSLVELLATTLKQAH 270

  Fly   266 ---------LLDKCLLGYSLLFSRLEECASSTCPPSINRMESSERQLV----HLLPEIIAGFKPQ 317
                     ||....|...||||.||.............:...|.:|.    | ||..|..|:|.
Human   271 ALFYTLPEGLLPDPALPCGLLFSTLETITGQHPAGKGTGVLQEEMKLCSWFKH-LPASIVEFQPT 334

  Fly   318 FD--VPQLTPEQLGSSLQQWLDKMNALAAAHLQQVFALVTNMQTIQDIKSA-------ARTNGRP 373
            ..  ...::.|.|..:||:|:...|......:..:...|.:|:.:..|:.|       ..||...
Human   335 LRTLAHPISQEYLKDTLQKWIHMCNEDIKNGITNLLMYVKSMKGLAGIRDAMWELLTNESTNHSW 399

  Fly   374 DFV-------------RLEQQLHLKRSQLDFYARKYVPLINARVREIIRSSWASAMKLTYEQVLL 425
            |.:             .:.|||.|.|  |....::....|::..:|::.|:            |.
Human   400 DVLCRRLLEKPLLFWEDMMQQLFLDR--LQTLTKEGFDSISSSSKELLVSA------------LQ 450

  Fly   426 LIEAGQSQPP------------LQIWREQSDDLPLSLAAALSDQPKRLANRTK-GYDGATIE--- 474
            .:|:..|..|            |.:|.|..:||| |.||.:|     :|||.: ...|.:::   
Human   451 ELESSTSNSPSNKHIHFEYNMSLFLWSESPNDLP-SDAAWVS-----VANRGQFASSGLSMKAQA 509

  Fly   475 -------LCKRFDSHL-------------------------------------ADIVQELNVMLQ 495
                   .|...||.|                                     |..|||   ||:
Human   510 ISPCVQNFCSALDSKLKVKLDDLLAYLPSDDSSLPKDVSPTQAKSSAFDRYADAGTVQE---MLR 571

  Fly   496 EQTTRAEDKVSLIEFLRETAEEQLTEYLSNLKG----LELRERPALLLALRNSLALVELCPNLKL 556
            .|:      |:.|:.:.:....:|......::|    |...:..::|...|...:|.||||:||.
Human   572 TQS------VACIKHIVDCIRAELQSIEEGVQGQQDALNSAKLHSVLFMARLCQSLGELCPHLKQ 630

  Fly   557 CFCQPSSWRQWTDNSAGLGIE--------------------HWQRICGLIEKEMLSFWLVIVDDV 601
            |....|      ::|.....|                    .||.:     ||:|     :...|
Human   631 CILGKS------ESSEKPAREFRALRKQGKVKTQEIIPTQAKWQEV-----KEVL-----LQQSV 679

  Fly   602 LAGHNCEEKLPKVINHEV-----------VLSDFALWQTLTLEQRDEDQEQSVQSTIRIPSQPRL 655
            :........:.||:.|..           ||:....|..|.: |.:.:...||.|.||:|:||..
Human   680 MGYQVWSSAVVKVLIHGFTQSLLLDDAGSVLATATSWDELEI-QEEAESGSSVTSKIRLPAQPSW 743

  Fly   656 SLQTYLHQLIQALNSVVPQTLPPKVLQAFIQRLIGKLLCHYEGLAHAECTK------ASQNIALQ 714
            .:|::|..|.|.:|.|....||...||..::..:.:::..||.|:..:..|      .:||.|||
Human   744 YVQSFLFSLCQEINRVGGHALPKVTLQEMLKSCMVQVVAAYEKLSEEKQIKKEGAFPVTQNRALQ 808

  Fly   715 LYFDLKFLERVFAISREE----RTLYD-QIHAQQNQLRDYIDPFDFELFAEHITAHVSRAASRLQ 774
            |.:||::|..|.....:|    |:..| :|....:.|...|||||.::|..|:.:::.|...|..
Human   809 LLYDLRYLNIVLTAKGDEVKSGRSKPDSRIEKVTDHLEALIDPFDLDVFTPHLNSNLHRLVQRTS 873

  Fly   775 GELGVLTPSAAAPSQGAAAASSLAHEADPNVLCLSSSGSTSLWFPLLPIVM--PQAAGRVTSAER 837
            ...|::|   ...:|.|..:|:...:...|:|.|:||   .:.|.|||:.|  .:.|....:.|.
Human   874 VLFGLVT---GTENQLAPRSSTFNSQEPHNILPLASS---QIRFGLLPLSMTSTRKAKSTRNIET 932

  Fly   838 KSPIQEPVEKTA--TTTPTRKSGGNGARKGDSSKSKSSAASFFGMSQEW 884
            |:.:..|...||  .|.|     |:..|:..|.:..:||.|.|.:.  |
Human   933 KAQVVPPARSTAGDPTVP-----GSLFRQLVSEEDNTSAPSLFKLG--W 974

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cog1NP_001262497.1 Vps51 4..84 CDD:285862 31/70 (44%)
COG1NP_061184.1 Vps51 17..>71 CDD:285862 26/49 (53%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165149190
Domainoid 1 1.000 144 1.000 Domainoid score I4629
eggNOG 1 0.900 - - E1_KOG2033
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H8411
Inparanoid 1 1.050 195 1.000 Inparanoid score I3831
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53002
OrthoDB 1 1.010 - - D221637at2759
OrthoFinder 1 1.000 - - FOG0006122
OrthoInspector 1 1.000 - - oto88442
orthoMCL 1 0.900 - - OOG6_104249
Panther 1 1.100 - - LDO PTHR31658
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4518
SonicParanoid 1 1.000 - - X5058
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.800

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