Protein Alignment Cog1 and cogc-1

DIOPT Version :10

• Sequence 1: NP_650162.1
• Gene: Cog1 / 41479
• FlyBaseID: FBgn0037998
• Length: 886
• Species: Drosophila melanogaster
• Sequence 2: NP_491128.4
• Gene: cogc-1 / 3565555
• WormBaseID: WBGene00003258
• Length: 787
• Species: Caenorhabditis elegans
• Alignment Length: 945
• Identity: 193/945 - (20%)
• Similarity: 343/945 - (36%)
• Gaps: 230/945 - (24%)

  Fly     8 LNVDTLFEQHSVSEIDEVHKKIQSVVENKREELRTHVGERYRDLLQAADTIAAMQTSAGTLMEQV 72
            ::||.|....||.:::.:.:.::..:|.|||.||..||.||||:|:|:..:..:.:.|..|...:
 Worm     1 MDVDRLMRDLSVEQLENIQQNLEKEMEGKRESLREMVGRRYRDVLEASSEVRHVCSLADKLASDI 65

  Fly    73 RHVQANCRSLNEQQLLGFQSTANASAKDAALKERNAGKKLQTYYGTMAQI------KLLTALPEL 131
                ||.|       :|:|||   ..:....:|:.||:.|......::.|      .|...:...
 Worm    66 ----ANTR-------VGYQST---HVRTGGREEQKAGEHLYAVNYLVSSIGGDSGEPLDDVVALC 116

  Fly   132 IWTHLDNDRFYAATELFIFSRHISTGLQLDGQSALMQKLPVARKQWEILRPFHVTIKQAILTALE 196
            :..||...         :.|.|.|..:..:.: ||..::...|.:.|.         |...|.|:
 Worm   117 MVEHLQKQ---------LISNHSSPMIHKNAR-ALTNRIVATRSELEF---------QNCSTLLD 162

  Fly   197 REELLQEMTVDCLQSLLLLDKSDLSTVLKSFLNLRSSAFLNCLQSGPSEPRRVKDRILASLNVLN 261
            ...  .:...:.|.::.||...|:|.:|:.:|..|.....:.::...:        ||..::.:.
 Worm   163 ISR--SDWATNQLAAIALLQGKDISQLLELYLEKRFEHVTHLIEDSAT--------ILNIVDEMK 217

  Fly   262 STVELLDKCLLGYSLLFS-------------RLEECASS--TCPPSINRMESSERQLVHLLPEII 311
            .|:.::::..:...|:.:             ..|.||..  :...:||  |..:|...||..::.
 Worm   218 KTLAVVEELFVHGELIHAIHSVCNGQYKCELIREMCADQAYSFEKTIN--EDMDRVWRHLREKLS 280

  Fly   312 ---AGFKPQFDVPQLTPEQLGSSLQQWLDKMNALAAAHLQQVFALVTNMQTIQDIKSAARTNGRP 373
               ||..|.        :.:|.....|::|..|:....:.:|.....|:..|.|:..|...:.:.
 Worm   281 GRGAGTLPS--------QLVGEKCAAWIEKTCAVTHKLVAEVCEYFDNLDQIIDLLQAITASLKQ 337

  Fly   374 DFVRLEQQLHLKRSQLDFYARKYVPLINARVREIIRSSWASAMKLTYEQVLLLIEAGQSQPPLQI 438
            |:.|:..    .||..|               ::::::.....|:...|::..||....:.
 Worm   338 DWPRIGS----NRSVYD---------------KLLQTAVVDKAKILLIQMIESIELFAKKR---- 379

  Fly   439 WREQSDDLPLSLAAALSDQPKRLANRTKGYDGATIELCKRFDSHLADIVQELNVM--LQEQTTRA 501
             .|.:.|.|   ..|:.|:      ||...|.         .||:....|..|.:  |.|...:.
 Worm   380 -FESTSDGP---QTAIFDE------RTYHPDS---------QSHIGISTQLYNCVKTLWESLEQT 425

  Fly   502 EDKVSLIE-------------FLRETAEEQLTEYLSNLKGL--ELRERPALLLA-LRNSLALVEL 550
            .:|.:..|             .|:||....:.:.|..|..|  :.:|..|..|| .|.:||||..
 Worm   426 NEKCAQFETICTPMADMATSNALKETMATNVLQLLLRLCELHSDKQEGSARFLARARLALALVHS 490

  Fly   551 CPNLKLCFCQPSSWRQWTDNSAGLGIEHWQRICGLIEKEMLSFWLVIVDDVLAGHNCEEKLPKVI 615
            ...|........|.|..:.|         ||:..:|||.:..|..|:||:.:...:..|.|....
 Worm   491 ESTLICKLLDKDSQRITSLN---------QRLHSIIEKNLGDFCEVVVDEHITVASLSEYLESFE 546

  Fly   616 NHEVVLSDFALWQTLTLEQRDEDQEQSVQSTIRIPSQPRLSLQTYLHQLIQAL-NSVVPQTLPPK 679
            .....|       .|.:|.:..|.....:.|:.|...|  .||:.|..:...| .:.|...|..|
 Worm   547 GGMYAL-------RLVMEFQTVDLPDVGEVTVPIALSP--PLQSILFDISSCLAEASVAHLLTKK 602

  Fly   680 VLQAF-------IQRLIGKLLCHYEGLAHAECTKASQNI----ALQLYFDLKFLERVFAISREER 733
            :.:..       :.:|||:         ..|..|.|.::    .||:.||.:.:..:|...|
 Worm   603 IRKRLDEHVSHRMAQLIGE---------RVEELKDSWHLPSRSTLQVLFDCQLIGAMFPSER--- 655

  Fly   734 TLYDQIHAQQNQLRDYIDPFDFELFAEHITAHVSRAASRLQGELGVLTPSAAAPSQGAAAASSLA 798
                 :.:..:.:..::||||..|.:..:.|:|....:|.|    ||.....|.:
 Worm   656 -----MRSVCSSIESHLDPFDVSLLSPLLAANVKLVYTRTQ----VLFSCLVADT---------- 701

  Fly   799 HEADPNVLCLSSSGSTSLWFPLLPIVMPQAAGRV--TSAERKSPIQEPVEKTATTTPTRKSGGNG 861
                     |||.          .:.:||:..::  .|...:.|.:.|:......|........|
 Worm   702 ---------LSSK----------EVQLPQSFSKIQDVSVHIEQPSRIPMVPRLDRTMNGDKKNGG 747

  Fly   862 AR----------KGDSSKSKSSAASFFG-MSQEWF 885
            ||          :..||||..|.::|:. :|..||
 Worm   748 ARLKNNKYLANPQQGSSKSTPSLSAFYDRISSSWF 782

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cog1	NP_650162.1	Vps51	7..84	CDD:462568	24/75 (32%)
cogc-1	NP_491128.4	None