Protein Alignment Cog1 and Cog1

DIOPT Version :9

• Sequence 1: NP_001262497.1
• Gene: Cog1 / 41479
• FlyBaseID: FBgn0037998
• Length: 886
• Species: Drosophila melanogaster
• Sequence 2: NP_001100532.2
• Gene: Cog1 / 303652
• RGDID: 1304594
• Length: 980
• Species: Rattus norvegicus
• Alignment Length: 1015
• Identity: 255/1015 - (25%)
• Similarity: 431/1015 - (42%)
• Gaps: 200/1015 - (19%)

  Fly    11 DTLFEQHSVSEIDEVHKKIQSVVENKREELRTHVGERYRDLLQAADTIAAMQTSAGTLMEQVRHV 75
            :.|||.|...||..:.:::::.:|:|:||||..||||||||::|||||..|:..|..|::.|:..
  Rat    19 NALFETHGAEEIRGLERQVRAEIEHKKEELRQMVGERYRDLIEAADTIGQMRRCAEGLVDAVQAT 83

  Fly    76 QANCRSLNEQQLLGFQSTANASAKDAALKERNAGKKLQTYYGTMAQIKLLTALPELIWTHLDNDR 140
            ...|..|.       |:.:.||....|.:.....:|   :|...||||||..:||.||:.::..:
  Rat    84 DQYCARLR-------QAGSAASRVPRAPQPHPPSEK---FYSMAAQIKLLLEIPEKIWSCMEASQ 138

  Fly   141 FYAATELFIFSRHISTGLQLDGQSA----LMQKLPVARKQWEILRPFHVTIKQAILTALEREELL 201
            ...||:|::...|:.:.||||..|:    ::.:.|:..:|......|..||.......|:.:.:.
  Rat   139 HLQATQLYLLCCHLHSLLQLDSSSSRYSPILSRFPILVRQVAAASHFRSTILHESKMLLKCQAVS 203

  Fly   202 QEMTVDCLQSLLLLDKSDLSTVLKSFLNLRSSAFLNCLQSGPSEPRRVKDRILASLNVLNSTVE- 265
            .:...:.|.|::||::|.....|..|| |...|.:..|.:.|.....:|.:|.:.:.:|.:|:.
  Rat   204 DQAVAEALCSIMLLEESSPRQALTDFL-LARKATIQTLLNQPHHGAGIKAQICSLVELLATTLNQ 267

  Fly   266 -----------LLDKCLLGYSLLFSRLEECASSTCPPSINRMESSERQLVHL------------L 307
                       :|....|...||||.||         ::.|...:.:.:..|            |
  Rat   268 AHALFYTLPEGVLPDPSLPCGLLFSTLE---------TVTRQHPTGKGISALQGEMKLCSWFRHL 323

  Fly   308 PEIIAGFKPQFD--VPQLTPEQLGSSLQQWLDKMNALAAAHLQQVFALVTNMQTIQDIKSA---- 366
            |..:..|:|...  ...::.|.|..:|::|:|..:......:..:...|.:|:.:..|:.|
  Rat   324 PASVTEFQPALRTLAHPISQEYLKGTLRKWIDMCSEDIKNGIGNLLMYVKSMKGLAGIRDAIWDL 388

  Fly   367 --------------ARTNGRP--DFVRLEQQLHLKRSQ------LDFYARKYVPLINARVREIIR 409
                          .|...:|  .:..|.|||.|.|.|      .|..:.....|:.:.::|:..
  Rat   389 LTNESASHSWEVVCQRLLEKPLLFWEDLMQQLFLDRLQTLTREGFDSISSSSKELLVSALQELEA 453

  Fly   410 SSWASAMKLTYEQVLLLIEAGQSQPPLQIWREQSDDLPLSLAAALSDQPKRLANRTK-GYDGATI 473
            ::..|...:.:||.:          .|.:|.|..:||| |.||.:|     :|||.: ...|.::
  Rat   454 NNSTSNKHVHFEQNM----------SLYLWSESPNDLP-SDAAWVS-----VANRAQFANSGLSM 502

  Fly   474 E----------LCKRFDSHLADIVQEL--------NVMLQEQTTRAEDKVSLIEFLRE--TAEEQ 518
            :          .|...||.|...:.:|        ..:|::.|...:.|.|..:...:  |.::.
  Rat   503 KAQAISPCVQNFCSALDSKLKVKLDDLLAYLPSSDTPLLKDTTHTHQAKTSAFDRYADAGTVQDM 567

  Fly   519 L-TEYLSNLKGL------ELR----------------ERPALLLALRNSLALVELCPNLKLCF-- 558
            | |:.::.:|.:      |||                :..|:|...|...:|.||||:||.|.
  Rat   568 LRTQSVACIKSVVGCIQAELRVIEEVTQDQKDVLHSTKLHAVLFMARLCQSLGELCPHLKQCIVG 632

  Fly   559 -CQPS-----SWRQWTDNSAG-----LGIE-HWQRICGLIEKEMLSFWLVIVDDVLAGHNCEEKL 611
             |..|     ..|.......|     |.:: .||.:     ||:|     :...|:|.......|
  Rat   633 KCGGSEKPAREVRALKKQGKGKAQDVLPVQAQWQEV-----KEVL-----LQQSVMAYRVWSAAL 687

  Fly   612 PKVI----NHEVVLSD-------FALWQTLTLEQRDEDQEQSVQSTIRIPSQPRLSLQTYLHQLI 665
            .||:    ...::|||       ...|..|.: |.:.:...||.|.||:|:||...:|::|..|.
  Rat   688 VKVLICGFTQSLLLSDAGSVLATATSWDELEI-QEETESGSSVTSKIRLPTQPSWYVQSFLFSLC 751

  Fly   666 QALNSVVPQTLPPKVLQAFIQRLIGKLLCHYEGLAHAECTK------ASQNIALQLYFDLKFLER 724
            |.:|.|....||...||..::..:.:::..||.|......|      .:||.||||.:||::|..
  Rat   752 QEVNRVGGHALPKITLQEMLKTCMAQVIAAYEQLTEENQIKKEGTFPMTQNRALQLLYDLRYLNI 816

  Fly   725 VFAISREE----RTLYD-QIHAQQNQLRDYIDPFDFELFAEHITAHVSRAASRLQGELGVLTPSA 784
            |.....||    |:..| :|....::|...|||||.::|..|:.::::|...|.....|::|
  Rat   817 VLTSKGEEVKSSRSKSDSRIEKMADRLEALIDPFDLDVFTPHLNSNLNRLVQRTSVLFGLVT--- 878

  Fly   785 AAPSQGAAAASSLAHEADPNVLCLSSSGSTSLWFPLLPIVM-----PQAAGRVTSAERKSPIQEP 844
            ...:|.|:.:|:...:...|:|.|:||   .:.|.|||:.|     .:|.||  ..|.::.:..|
  Rat   879 GTENQFASRSSTFNSQEPHNILPLASS---QIRFGLLPLSMTSTRKARATGR--GIESQTQVGPP 938

  Fly   845 VEKTATTTPTRKSGGNGARKGDSSKSKSSAASFFGMSQEW 884
            . .:....||... |:..|:..|.:..|.|.|.|.::  |
  Rat   939 A-LSRVGDPTAHP-GSLFRQLASEEDGSPAPSLFKLA--W 974

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cog1	NP_001262497.1	Vps51	4..84	CDD:285862	31/72 (43%)
Cog1	NP_001100532.2	Vps51	17..91	CDD:285862	30/71 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343058
Domainoid	1	1.000	143	1.000	Domainoid score	I4560
eggNOG	1	0.900	-	-		E1_KOG2033
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8411
Inparanoid	1	1.050	194	1.000	Inparanoid score	I3754
OMA	1	1.010	-	-		QHG53002
OrthoDB	1	1.010	-	-		D221637at2759
OrthoFinder	1	1.000	-	-		FOG0006122
OrthoInspector	1	1.000	-	-		oto95582
orthoMCL	1	0.900	-	-		OOG6_104249
Panther	1	1.100	-	-	LDO	PTHR31658
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5058
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770