Protein Alignment Cog1 and Cog1

DIOPT Version :10

• Sequence 1: NP_650162.1
• Gene: Cog1 / 41479
• FlyBaseID: FBgn0037998
• Length: 886
• Species: Drosophila melanogaster
• Sequence 2: NP_038609.3
• Gene: Cog1 / 16834
• MGIID: 1333873
• Length: 980
• Species: Mus musculus
• Alignment Length: 1013
• Identity: 245/1013 - (24%)
• Similarity: 408/1013 - (40%)
• Gaps: 196/1013 - (19%)

  Fly    11 DTLFEQHSVSEIDEVHKKIQSVVENKREELRTHVGERYRDLLQAADTIAAMQTSAGTLMEQVRHV 75
            :.|||.|...||..:.:::::.:|:|:||||..||||||||::|||||..|:..|..|::.|:..
Mouse    19 NALFETHGAEEIRGLERQVRAEIEHKKEELRQMVGERYRDLIEAADTIGQMRRCAEGLVDAVQAT 83

  Fly    76 QANCRSLNEQQLLGFQSTANASAKDAALKERNAGKKLQTYYGTMAQIKLLTALPELIWTHLDNDR 140
            ...|..|.       |:.:.|.....|.:.:...:|   :|...||||||..:||.||:.::..:
Mouse    84 DQYCARLR-------QAGSVAPRVPRAPQPQPPSEK---FYSMAAQIKLLLEIPEKIWSAMEASQ 138

  Fly   141 FYAATELFIFSRHISTGLQLDGQ----SALMQKLPVARKQWEILRPFHVTIKQAILTALEREELL 201
            ...||:|::...|:.:.||||..    |.::.:.|:..:|......|..||.......|:.:.:.
Mouse   139 HLQATQLYLLCCHLHSLLQLDSSNSRYSPILSRFPILIRQVAAASHFRSTILHESKMLLKCQAVS 203

  Fly   202 QEMTVDCLQSLLLLDKSDLSTVLKSFLNLRSSAFLNCLQSGPSEPRRVKDRILASLNVLNSTVE- 265
            .:...:.|.|::||::|.....|..|| |...|.:..|.:.......:|.:|.:.:.:|.:|:.
Mouse   204 DQAVAEALCSIMLLEESSPRQALTDFL-LARKATIQTLLNQSHHGAGIKAQICSLVELLATTLNQ 267

  Fly   266 -----------LLDKCLLGYSLLFSRLEECASSTCPPSINRMESSERQLVHL------------L 307
                       :|....|...||||.||         ::.|...:.:.:..|            |
Mouse   268 AHALFYTLPEGVLPDPSLPCGLLFSTLE---------TVTRQHPTGKGIGALQGEMKLCSWFRHL 323

  Fly   308 PEIIAGFKPQFD--VPQLTPEQLGSSLQQWLDKMNALAAAHLQQVFALVTNMQTIQDIKSA---- 366
            |..|..|:|...  ...::.|.|..:||:|:|..|......:..:...|.:|:.:..|:.|
Mouse   324 PTSIIEFQPTLRTLAHPISQEYLKDTLQKWIDMCNEDIKNGIGNLLMYVKSMKGLAGIRDAIWDL 388

  Fly   367 --------------ARTNGRP--DFVRLEQQLHLKRSQ------LDFYARKYVPLINARVREIIR 409
                          .|...:|  .:..|.|||.|.|.|      .:..:.....|:.:.::|:..
Mouse   389 LSNESASHSWEVVCQRLLEKPLLFWEDLMQQLFLDRLQTLTREGFESISNSSKELLVSALQELET 453

  Fly   410 SSWASAMKLTYEQVLLLIEAGQSQPPLQIWREQSDDLP-----LSLAAALSDQPKRLANRTKGYD 469
            ::..|...:.:||.:...          :|.|..:|||     :|:|.........|:.:.:...
Mouse   454 NNSTSNKHVHFEQNMSFF----------LWSESPNDLPSDAAWVSVANRAQFASSGLSMKAQAIS 508

  Fly   470 GATIELCKRFDSHLADIVQELNVMLQEQTT------------------RAEDKVSLIEFLRE--- 513
            ......|...||.|...:.:|...|....|                  |..|..::.:.||.
Mouse   509 PCVQNFCSALDSKLKVKLDDLLAYLPSSDTPLLKDTTPTHQPKNSAFDRYADAGTVQDMLRTQSV 573

  Fly   514 ---------------TAEEQLTEYLSNLKGLELRERPALLLALRNSLALVELCPNLKLCF---CQ 560
                           |.||...|....|...:|.   |:|...|...:|.||||:||.|.   |.
Mouse   574 ACIKSVVGCIQAELCTIEEVTREQKDVLHSTKLH---AVLFMARLCQSLGELCPHLKQCVVGQCG 635

  Fly   561 PS-----SWRQWTDNSAGLGIE------HWQRICG-LIEKEMLSF--W-LVIVDDVLAGHNCEEK 610
            .|     ..|.......|...:      .||.:.. |:::.::::  | ..:|..::.|......
Mouse   636 GSEKPAREARALKKQGKGRAQDVLPAQAQWQGVKEVLLQQSVMAYRVWSTALVKFLICGFTRSLL 700

  Fly   611 LPKVINHEVVLSDFALWQTLTLEQRDEDQEQSVQSTIRIPSQPRLSLQTYLHQLIQALNSVVPQT 675
            |....:   ||:....|..|.: |.:.:...||.|.||:|:||...:|::|..|.|.:|.|....
Mouse   701 LRDAGS---VLATATNWDELEI-QEETESGSSVTSKIRLPTQPSWYVQSFLFSLCQEVNRVGGHA 761

  Fly   676 LPPKVLQAFIQRLIGKLLCHYEGLAHAECTK------ASQNIALQLYFDLKFLERVFAISREE-- 732
            ||...||..::..:.:::..||.|......|      .:||.||||.:||::|..|.:...||
Mouse   762 LPKVTLQEMLKTCMAQVIAAYEQLTEENQIKKEGAFPMTQNRALQLLYDLRYLTMVLSSKGEEVK 826

  Fly   733 --RTLYD-QIHAQQNQLRDYIDPFDFELFAEHITAHVSRAASRLQGELGVLTPSAAAPSQGAAAA 794
              |:..| ::.....:|...|||||.::|..|:.::::|...|.....|::|   ...:|.|:.:
Mouse   827 SGRSKADSRMEKMTERLEALIDPFDLDVFTPHLNSNLNRLVQRTSVLFGLVT---GTENQFASRS 888

  Fly   795 SSLAHEADPNVLCLSSSGSTSLWFPLLPIVMPQAAGRVTSAERKSPIQEPVEKTATTTPTRKSGG 859
            |:...:...|:|.|:||   .:.|.|||:.|       ||..:.......||..|...|...|
Mouse   889 STFNSQEPHNILPLASS---QIRFGLLPLSM-------TSTRKARATSRSVETQAQVGPPALS-- 941

  Fly   860 NGARKGD-------------SSKSKSSAASFFGMSQEW 884
               |.||             |.:..|.|.|.|.::  |
Mouse   942 ---RVGDPTTHPGSLFRQLASEEDDSPAPSLFKLA--W 974

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cog1	NP_650162.1	Vps51	7..84	CDD:462568	31/72 (43%)
Cog1	NP_038609.3	Vps51	17..92	CDD:462568	31/72 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	923..950