DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cog1 and cog1

DIOPT Version :9

Sequence 1:	NP_001262497.1	Gene:	Cog1 / 41479	FlyBaseID:	FBgn0037998	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	XP_012822978.2	Gene:	cog1 / 100497164	XenbaseID:	XB-GENE-1012192	Length:	978	Species:	Xenopus tropicalis

Alignment Length:	1036	Identity:	253/1036 - (24%)
Similarity:	424/1036 - (40%)	Gaps:	243/1036 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LFEQHSVSEIDEVHKKIQSVVENKREELRTHVGERYRDLLQAADTIAAMQTSAGTLMEQVRHVQA 77
            |||.||..||..:.:::::.:|.|:||||..||||||||::|||||..|:.|:|.::..||.::.
Frog    16 LFEAHSAEEIRVLERRVRAEIEQKKEELRQMVGERYRDLIEAADTIGEMRRSSGLVVGAVRDMEK 80

  Fly    78 NCRSLNEQQLLGFQSTANASAKDAALKERNAGKKLQTYYGTMAQIKLLTALPELIWTHLDNDRFY 142
            .|.||..:|..|...|.         ::|.|.:..:.:|.|.||||||..:||.||:.::..::.
Frog    81 YCGSLKCKQSTGAAGTQ---------RDRAASQCQEKFYCTAAQIKLLLEVPEKIWSAMEASQYL 136

  Fly   143 AATELFIFSRHISTGLQLDGQ----SALMQKLPVARKQWEILRPFHVTIKQAILTALEREELLQE 203
            .||:|::...|:.:.|.||..    |.::.:.|:..:|......|..||.|...:.|:......:
Frog   137 HATQLYLLCCHLHSLLHLDSSPSRYSPVLARFPILVRQVAAAGTFRTTILQESKSLLKCPSASDQ 201

  Fly   204 MTVDCLQSLLLLDKSDLSTVLKSFLNLRSSAFLNCLQSGPSEPRRVKDRILASLNVLNSTVELLD 268
            .....|.|::||:.|.....|..:| |...|.:..|.:.|.....:|.::.       |.||||.
Frog   202 AVAGALCSIILLEGSTPRQALTDYL-LARKAGIQQLLNQPHHGLGIKAQVC-------SLVELLA 258

  Fly   269 KCLL-GYSLLFSRLEEC---ASSTC------------------------------------PPSI 293
            ..|. .::|.:::.||.   .|.||                                    |||:
Frog   259 NTLYQAHALFYTQSEEMKPDPSLTCGLLFTMLDTVTGQQGGGKGINVLKEEMKSVSWFKHLPPSV 323

  Fly   294 NRMESSERQLVHLLPEIIAGFKPQFDVPQLTPEQLGSSLQQWLDKMNALAAAHLQQVFALVTNMQ 358
            ...:...|.|.|                .::.|.|..:||||:...|......:..:...|.:::
Frog   324 VNFQPERRTLAH----------------PISQEYLCETLQQWISMCNEDIKVGISALLVYVKSLK 372

  Fly   359 TIQDIKSAA------------------RTNGRP-----DFVRLEQQLHLKRSQ------LDFYAR 394
            .:..|:.|.                  |...||     |.:   |||.|:|.|      .:..:|
Frog   373 GLAGIRDAVWELLTSESMSQNWDKVCHRLLDRPFRFWEDIL---QQLFLERLQALTKEGFESISR 434

  Fly   395 KYVPLINARVREIIRSSWASAMKLTYEQVLLLIEAGQSQPPLQIWREQSDDLPLSLAAALSDQPK 459
            ..|.|:.:.::| :..:..:...|.:|..:...          :|.|...|||.. ||.::...:
Frog   435 NLVQLLMSSLQE-LEGNPETLKHLQHESNICSF----------LWSEGPSDLPPD-AAWVNVGSR 487

  Fly   460 RLANRTKGYDGATIE----------LCKRFDSHLADIVQELNVMLQEQ-----------TTRAED 503
            .|..|:    |.:::          ||...||.|...:::|...|..:           ||.|
Frog   488 GLQCRS----GLSLKAQAVTPCIQSLCATLDSQLKVKLEDLCSYLPGESPVTEKHNEFVTTAA-- 546

  Fly   504 KVSLIEFLRE--TAEEQLTEY---------------LSNLK-------GLEL--RERPALLLALR 542
            |:|..:...:  |.:|.|:.:               |.::|       |:.|  .:..|:|...|
Frog   547 KISAFDRYGDASTVQEMLSHHCLSCMQQIQDSVNTTLQSVKHEGLVDHGVALFSPKLTAVLFLAR 611

  Fly   543 NSLALVELCPNLKLC-----------FCQPSSWRQWTDNSAGLGIE------HWQRICGLIEKEM 590
            ...:|.||||:||.|           |.:|.|.::   ...|..::      .||.:...::|:.
Frog   612 LCQSLCELCPHLKQCILGKSVSTEQSFREPRSTKK---TGKGKKVDSHAVSCKWQDLKDKLKKQS 673

  Fly   591 L---SFWLVIVDDVLAGHNCEEKLPKVINHEVV-------LSDFALWQTLTLEQRDEDQEQSVQS 645
            |   |.|...|         .:.|.....|.::       |:....|..:.: |.:.:...||.|
Frog   674 LEAYSIWSSFV---------VKHLVTSFTHTLLINTAGSALATATHWDEIEI-QEETEAGSSVTS 728

  Fly   646 TIRIPSQPRLSLQTYLHQLIQALNSVVPQTLPPKVLQAFIQRLIGKLLCHYEGLAH--------A 702
            .||:|.|....:|..|..|.||:|:|....||...||..::..:.:::..||.|.|        .
Frog   729 KIRLPGQCSWYVQMLLFSLCQAVNNVGGHALPRVTLQELLRHCLEEVVGAYESLCHKSLDKMKSK 793

  Fly   703 ECTKASQNIALQLYFDLKFLERVFAISREE------RTLYDQIHAQQNQLRDYIDPFDFELFAEH 761
            :.:..:|..||||.|||:::..:.: ||.|      .....:|....:||...|||||.::|..|
Frog   794 QASSLTQARALQLLFDLRYMNLILS-SRSEDLKSSKSKQESRIQKVADQLETCIDPFDLDVFTPH 857

  Fly   762 ITAHVSRAASRLQGELGVLTPSAAAPSQGAAAASSLAHEADPNVLCLSSSGSTSLWFPLLPIVMP 826
            :.|:::|.|.|.....|:||   .|.:|....:|::..:...|||.|:||   .:.|.|||:.|.
Frog   858 LNANLNRYAQRTSVLFGLLT---GAENQFITRSSTVGLQETHNVLPLASS---QIRFGLLPLSMS 916

  Fly   827 QAAGRVTSAERKSPIQEPVEKTATTTPTRKSG---GNGARKGDSSKSKSSAASFFGMSQEW 884
            .:......||..:.||..:.:   ..|:.:.|   |:..|:..:...::.:.|.|.:.  |
Frog   917 SSRKTKGRAEEDAKIQVTLSE---VPPSEEEGFRPGSLFRQLATQDEEAPSQSLFKLG--W 972

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cog1	NP_001262497.1	Vps51	4..84	CDD:285862	34/70 (49%)
cog1	XP_012822978.2	Vps51	12..>67	CDD:400855	27/50 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	138	1.000	Domainoid score	I4819
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8411
Inparanoid	1	1.050	199	1.000	Inparanoid score	I3678
OMA	1	1.010	-	-		QHG53002
OrthoDB	1	1.010	-	-		D221637at2759
OrthoFinder	1	1.000	-	-		FOG0006122
OrthoInspector	1	1.000	-	-		oto102321
Panther	1	1.100	-	-	LDO	PTHR31658
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4518
SonicParanoid	1	1.000	-	-		X5058
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110