DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4830 and PCS60

DIOPT Version :9

Sequence 1:	NP_650160.1	Gene:	CG4830 / 41477	FlyBaseID:	FBgn0037996	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_009781.3	Gene:	PCS60 / 852523	SGDID:	S000000426	Length:	543	Species:	Saccharomyces cerevisiae

Alignment Length:	500	Identity:	121/500 - (24%)
Similarity:	200/500 - (40%)	Gaps:	67/500 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 KDIIGISARN-----TTYIMPTAVACFFHGTPFQSANPILEESTLKHLYNISKPKIIFTDADHYD 139
            :|.:.||.||     ..::..|..|..  |.|.   ||..:|.......|..|.|.|...
Yeast    62 QDTVAISMRNGLEFIVAFLGATMDAKI--GAPL---NPNYKEKEFNFYLNDLKSKAICVP----- 116

  Fly   140 KLYSATSAFKPEIILTTGTKDGVLSIQDLLAPTKTEF-----FYQP------------------- 180
               ..|:..:...||.:.:..|...::  ||...|.|     .|.|
Yeast   117 ---KGTTKLQSSEILKSASTFGCFIVE--LAFDATRFRVEYDIYSPEDNYKRVIYRSLNNAKFVN 176

  Fly   181 -TPLK----EGPSQTVAILTSSGTTGMPKAVCISNDILTQETV-FVNGY-----DTIFISASLDW 234
             .|:|    ...|....||.:||||..||.|.:.:..:.:.|: ..|.|     |..::...|..
Yeast   177 TNPVKFPGFARSSDVALILHTSGTTSTPKTVPLLHLNIVRSTLNIANTYKLTPLDRSYVVMPLFH 241

  Fly   235 ITGLWATIFSTVNGCTRIISSKPFAADYFVYLVSKYSITYALIPPEHCCSLLDCPTATPEKLGSL 299
            :.||...:.||......::....|....|.....||:..:....|.....:|:.|  .|.....:
Yeast   242 VHGLIGVLLSTFRTQGSVVVPDGFHPKLFWDQFVKYNCNWFSCVPTISMIMLNMP--KPNPFPHI 304

  Fly   300 TKLNFGGGRMTQATVERVKKLAPNGVLNSSYGMTEVGFIVFNH----GHLKLTAAGNPLPGIQVK 360
            ..:......:..||..:::| ..|..:..:|.|||....:.::    |..|....|.| .|:.|.
Yeast   305 RFIRSCSSALAPATFHKLEK-EFNAPVLEAYAMTEASHQMTSNNLPPGKRKPGTVGQP-QGVTVV 367

  Fly   361 IVDDDGNQLGVNQTGEIIVHNGFSWNGYFADPEATKA-MQDEEGWFHTGDMGYFDEDDYLYMTDR 424
            |:||:.|.|...:.||:.:.......||..:|:|.|. ....|.:|.|||.||||.:.:|.:|.|
Yeast   368 ILDDNDNVLPPGKVGEVSIRGENVTLGYANNPKANKENFTKRENYFRTGDQGYFDPEGFLVLTGR 432

  Fly   425 KKEVLKWKGLQMWPAEVEAVIDELPEVKRVCVIGVYDETQGDVPGALVVREDNATLTAQQVIDHV 489
            .||::...|.::.|.|::.::...|::......||.|:..|.|..|.:|.:....:|.:::::.:
Yeast   433 IKELINRGGEKISPIELDGIMLSHPKIDEAVAFGVPDDMYGQVVQAAIVLKKGEKMTYEELVNFL 497

  Fly   490 AKRLPDIQKQLRAGVQFADEIPQNHNGKVVRRYARDLFVALSKKN 534
            .|.|...  ::...|.|.|::|:...||:.||...:.| |.|.:|
Yeast   498 KKHLASF--KIPTKVYFVDKLPKTATGKIQRRVIAETF-AKSSRN 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4830	NP_650160.1	CaiC	18..529	CDD:223395	118/493 (24%)
CG4830	NP_650160.1	AFD_class_I	46..518	CDD:302604	114/482 (24%)
PCS60	NP_009781.3	FACL_fum10p_like	18..531	CDD:341249	117/489 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810