Protein Alignment CG4830 and ACSS3

DIOPT Version :10

• Sequence 1: NP_650160.1
• Gene: CG4830 / 41477
• FlyBaseID: FBgn0037996
• Length: 534
• Species: Drosophila melanogaster
• Sequence 2: NP_078836.1
• Gene: ACSS3 / 79611
• HGNCID: 24723
• Length: 686
• Species: Homo sapiens
• Alignment Length: 630
• Identity: 143/630 - (22%)
• Similarity: 225/630 - (35%)
• Gaps: 174/630 - (27%)

  Fly    13 KIW-KGIPQNNPFKPETSLGRIIFKNMRN-------W----PKNVC------QISDSEGVEV--- 56
            :.| |...|.:.:||.|       |.:.|       |    ..|:|      .|.:.:|.::
Human    75 RFWGKAAEQISWYKPWT-------KTLENKHSPSTRWFVEGMLNICYNAVDRHIENGKGDKIAII 132

  Fly    57 ------------TFGQALTWAIRIAQQLKSRGLDHKDIIGISARNTTYIMPTAVAC----FFHGT 105
                        |:.:.|....::|..|...|:...|.:.|........|.|.:||    ..|..
Human   133 YDSPVTNTKATFTYKEVLEQVSKLAGVLVKHGIKKGDTVVIYMPMIPQAMYTMLACARIGAIHSL 197

  Fly   106 PFQSANPILEESTLKHLYNISKPKIIFTDADHYDKLYSATSAFKPEIILTTGTK-DGVLSIQDLL 169
            .|.........|.:.|:    |||::.|          |:...:|      |.: :.|..:::.|
Human   198 IFGGFASKELSSRIDHV----KPKVVVT----------ASFGIEP------GRRVEYVPLVEEAL 242

  Fly   170 -----APTKTEFFYQP----TPLKEG---------------------PSQTVAILTSSGTTGMPK 204
                 .|.|...:.:|    .||..|                     ....:.||.:|||||:||
Human   243 KIGQHKPDKILIYNRPNMEAVPLAPGRDLDWDEEMAKAQSHDCVPVLSEHPLYILYTSGTTGLPK 307

  Fly   205 AVCISNDILTQETVFVNGY-----------------DTIFISASLDWITG-LWATIFSTVNGCTR 251
            .|...          ..||                 :..:.::.|.|:.| .:......::|.|.
Human   308 GVIRP----------TGGYAVMLHWSMSSIYGLQPGEVWWAASDLGWVVGHSYICYGPLLHGNTT 362

  Fly   252 II-SSKPF----AADYFVYLVSKYSITYALIPPEH-CCSLLDCPTATPE-----------KLGSL 299
            :: ..||.    |..||..|.            || ..:|...|||...           |..||
Human   363 VLYEGKPVGTPDAGAYFRVLA------------EHGVAALFTAPTAIRAIRQQDPGAALGKQYSL 415

  Fly   300 TK---LNFGGGRMTQATVERVKKLAPNGVLNSSYGMTEVGFIV----FNHGHLKLT---AAGNPL 354
            |:   |...|.|....|:|..|.:....||: .:..||.|..:    ...|:.|..   .||..:
Human   416 TRFKTLFVAGERCDVETLEWSKNVFRVPVLD-HWWQTETGSPITASCVGLGNSKTPPPGQAGKSV 479

  Fly   355 PGIQVKIVDDDGNQLGVNQTGEIIVH-----NGFSWNGYFADPEATKAMQDEE--GWFHTGDMGY 412
            ||..|.|:||:..:|.....|.|:|.     ..||  |.:.:.||.|.:..|:  |::.|.|.||
Human   480 PGYNVMILDDNMQKLKARCLGNIVVKLPLPPGAFS--GLWKNQEAFKHLYFEKFPGYYDTMDAGY 542

  Fly   413 FDEDDYLYMTDRKKEVLKWKGLQMWPAEVEAVIDELPEVKRVCVIGVYDETQGDVPGALVVREDN 477
            .||:.|||:..|..:|:...|.::....:|..|.....|....|:|..|..:|.||.||.|...:
Human   543 MDEEGYLYVMSRVDDVINVAGHRISAGAIEESILSHGTVADCAVVGKEDPLKGHVPLALCVLRKD 607

  Fly   478 ATLTAQQVIDHVAKRLPDIQKQLRA--GVQFADEIPQNHNGKVVR 520
            ...|.:||::.:.|.:......:.|  ...|..::|:..:||:.|
Human   608 INATEEQVLEEIVKHVRQNIGPVAAFRNAVFVKQLPKTRSGKIPR 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4830	NP_650160.1	Firefly_Luc_like	46..518	CDD:341237	131/581 (23%)
ACSS3	NP_078836.1	PrpE	62..679	CDD:341271	143/630 (23%)