DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4830 and DIP2B

DIOPT Version :9

Sequence 1:	NP_650160.1	Gene:	CG4830 / 41477	FlyBaseID:	FBgn0037996	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_775873.2	Gene:	DIP2B / 57609	HGNCID:	29284	Length:	1576	Species:	Homo sapiens

Alignment Length:	634	Identity:	127/634 - (20%)
Similarity:	216/634 - (34%)	Gaps:	170/634 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 IPQNNPFKPETSLGRIIFKNMRNWPKNVC-QISDSEGVEVTFGQALTW---AIRIAQQLKSRGLD 78
            |.:|:..:....|..|:....:..|.:|. .:.:::|..|.....|..   |.|||..|..:|
Human   979 IEENDLVRKHQFLAEILQWRAQATPDHVLFMLLNAKGTTVCTASCLQLHKRAERIASVLGDKG-- 1041

  Fly    79 HKDIIGISARNTTYIMPTAV-------ACFFHG------TPFQSANPILEESTLKHLYNISKPKI 130
            |.:    :..|...:.|..:       .|.:.|      .|..:.|......|::.:.::||...
Human  1042 HLN----AGDNVVLLYPPGIELIAAFYGCLYAGCIPVTVRPPHAQNLTATLPTVRMIVDVSKAAC 1102

  Fly   131 IFTDADHYDKLYSATSAFKPEIILTTGTKDGVLSIQDLLAPTKTEFFYQPTPLKEGPSQTVAILT 195
            |.|.......|.|..:|...::    .|...::...||......:.:..|||      :.:|.|.
Human  1103 ILTSQTLMRLLRSREAAAAVDV----KTWPTIIDTDDLPRKRLPQLYKPPTP------EMLAYLD 1157

  Fly   196 -SSGTTGMPKAVCISNDILTQETVFVNG-----------YDTIFISASLDWITG----LWATIFS 244
             |..||||...|.:|:..       ||.           |.:..|:..||...|    ||. :.|
Human  1158 FSVSTTGMLTGVKMSHSA-------VNALCRAIKLQCELYSSRQIAICLDPYCGLGFALWC-LCS 1214

  Fly   245 TVNGCTRI-ISSKPFAADYFVYL--VSKYSI-----TYALIPPEHCCSLLDCPTATPEKLGSLTK 301
            ..:|...: |.......:.|::|  |::|.|     :|:::  |.|...|.......:..|
Human  1215 VYSGHQSVLIPPMELENNLFLWLSTVNQYKIRDTFCSYSVM--ELCTKGLGNQVEVLKTRG---- 1273

  Fly   302 LNFGGGRMTQATVERVKK---------------LAPNGVLNSSYGMTEVGFIV------------ 339
            :|....|......|...:               |:|..|..:......|...:
Human  1274 INLSCVRTCVVVAEERPRVALQQSFSKLFKDIGLSPRAVSTTFGSRVNVAICLQGTSGPDPTTVY 1338

  Fly   340 -----FNHGHLKLTAAGNP-----------LPGIQVKIVD-DDGNQLGVNQTGEIIVHNGFSWNG 387
                 ..|..::|...|.|           |||::|.||: :....:|.:..|||.|::..:.:|
Human  1339 VDLKSLRHDRVRLVERGAPQSLLLSESGKILPGVKVVIVNPETKGPVGDSHLGEIWVNSPHTASG 1403

  Fly   388 YFA--DPEATKAMQ----------DEEGWFHTGDMGYF----------DEDDYLYMTDRKKEVLK 430
            |:.  |.|..:|..          .:..|..||.:|:.          :..|.||:.....|.|:
Human  1404 YYTIYDSETLQADHFNTRLSFGDAAQTLWARTGYLGFVRRTELTAATGERHDALYVVGALDETLE 1468

  Fly   431 WKGLQMWPAEVEAVIDELPEVKRVCVIGVYD-------ETQGDVPGAL--------VVREDNATL 480
            .:||:..|.::|..:..:......|.:..:.       |..|....||        ||.|::..:
Human  1469 LRGLRYHPIDIETSVSRIHRSIAECAVFTWTNLLVVVVELCGSEQEALDLVPLVTNVVLEEHYLI 1533

  Fly   481 TAQQVIDHVAKRLPDIQKQLRAGVQFADEIPQNHNGKVVRRYARDLFVA 529
            ....|:             :..||     ||.|..|:..|.:.||.|:|
Human  1534 VGVVVV-------------VDPGV-----IPINSRGEKQRMHLRDSFLA 1564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4830	NP_650160.1	CaiC	18..529	CDD:223395	126/632 (20%)
CG4830	NP_650160.1	AFD_class_I	46..518	CDD:302604	116/593 (20%)
DIP2B	NP_775873.2	DMAP_binding	14..131	CDD:283995
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..167
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	179..201
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	217..246
		CaiC	336..912	CDD:223395
		AFD_class_I	360..924	CDD:302604
		AMP-binding	995..1470	CDD:278902	99/504 (20%)
		AFD_class_I	1012..1565	CDD:302604	121/601 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900