DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4830 and dip2ba

DIOPT Version :9

Sequence 1:	NP_650160.1	Gene:	CG4830 / 41477	FlyBaseID:	FBgn0037996	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	XP_009295115.1	Gene:	dip2ba / 405899	ZFINID:	ZDB-GENE-040426-2305	Length:	1587	Species:	Danio rerio

Alignment Length:	656	Identity:	133/656 - (20%)
Similarity:	207/656 - (31%)	Gaps:	242/656 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 WPKNVCQ--------------------ISDSEGVEV---TFGQALTWAIRIAQQLKSRGLDHKDI 82
            ||.|:.|                    :.:::||.|   |..|....|.:|...|..||
Zfish   995 WPTNMHQFLSEALQWRAQTDPDHVLYMLLNAKGVAVSTATCSQLHKRAEKITAALLERG------ 1053

  Fly    83 IGI-SARNTTYIMPTAV--ACFFHGTPFQSANPILEE-----------STLKHLYNISKPKIIFT 133
             || :..|...:.|..:  ...|:|..:....|:...           .|::.:.::||...|.|
Zfish  1054 -GINTGDNVVLLYPPGIDLIASFYGCLYAGCIPVTVRPPHPQNLSATLPTVRMIIDVSKAACILT 1117

  Fly   134 DADHYDKLYSATSAFKPEIILTTGTKDGVLSIQDLLAPTKTEFFYQPTPLKEGPSQTVAILT-SS 197
            .......|.|..:|..    :...|...::...||........:..||      ::.:|.|. |.
Zfish  1118 TQTLMKTLRSKEAAAS----VNVKTWPNIIDTDDLPRKRPASIYKPPT------AEMLAYLDFSV 1172

  Fly   198 GTTGMPKAVCISNDILTQETVFVNGYDTIFISASLDWITGLWATIFSTVNGCTRII-------SS 255
            .||||...|.:|:                                 |.||...|.|       ||
Zfish  1173 STTGMLTGVKMSH---------------------------------SAVNALCRSIKLQCELYSS 1204

  Fly   256 K-------PFAADYFVY--LVSKYSITYA-LIPPEHCCSLLDCPTATPEKLGSLTKLNF------ 304
            :       |:....||.  |.|.||...: ||||      ::..|:.|..|.:|::...
Zfish  1205 RQIAICMDPYCGLGFVLWCLSSVYSGHQSILIPP------MELETSLPLWLSTLSQYKIRDTFCS 1263

  Fly   305 ---------GGGRMTQATVERVKKLA------------PNGVLNSSYG-------------MTEV 335
                     |.|..|:|...|...|:            |...|..|:.             .|..
Zfish  1264 YSVMELCTKGLGTQTEALKARNVNLSCVRSCVVIAEERPRLALTQSFSKLFKDLGLSPRAVSTAF 1328

  Fly   336 GFIV-----------------------FNHGHLKLTAAGNP-----------LPGIQVKIVD-DD 365
            |..|                       ..|..::|...|.|           |||::|.||: :.
Zfish  1329 GSRVNLAICLQGTAGPDPSTVYVDMKSLRHDRVRLVERGAPQSLPLMESGTMLPGVRVIIVNPET 1393

  Fly   366 GNQLGVNQTGEIIVHNGFSWNGYF---------ADPEATK-AMQDEEG-WFHTGDMGYF------ 413
            ...||.:..|||.|::..:.:||:         ||...|: :..|.|. |..||.:|:.
Zfish  1394 KGPLGDSHLGEIWVNSPHNASGYYTIYGEESLQADHFNTRLSFGDTETLWARTGYLGFVKRTELL 1458

  Fly   414 ----DEDDYLYMTDRKKEVLKWKGLQMWPAEVEAVID-------ELPEVKRVCVIGVYDETQGDV 467
                |..|.|::.....|.|:.:||:..|.::|..:.       |........::.|..|..|..
Zfish  1459 DASGDRHDALFVVGSLDETLELRGLRYHPIDIETSVSRAHRSIAESAVFTWTNLLVVVVELSGSE 1523

  Fly   468 PGAL---------VVREDNATLTAQQVIDHVAKRLPDIQKQLRAGVQFADEIPQNHNGKVVRRYA 523
            ..||         |::|.:..:....::|              .||     ||.|..|:..|.:.
Zfish  1524 QEALDLVPLVTNVVLKEHHLIVGVVVIVD--------------PGV-----IPINSRGEKQRMHL 1569

  Fly   524 RDLFVA 529
            ||.|:|
Zfish  1570 RDSFLA 1575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4830	NP_650160.1	CaiC	18..529	CDD:223395	132/654 (20%)
CG4830	NP_650160.1	AFD_class_I	46..518	CDD:302604	125/638 (20%)
dip2ba	XP_009295115.1	DMAP_binding	8..124	CDD:283995
		CaiC	339..915	CDD:223395
		Dip2	363..927	CDD:213273
		AMP-binding	1007..1481	CDD:278902	105/529 (20%)
		Dip2	1024..1576	CDD:213273	129/627 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900