DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4830 and CG5568

DIOPT Version :9

Sequence 1:	NP_650160.1	Gene:	CG4830 / 41477	FlyBaseID:	FBgn0037996	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_647992.1	Gene:	CG5568 / 38658	FlyBaseID:	FBgn0035641	Length:	545	Species:	Drosophila melanogaster

Alignment Length:	537	Identity:	195/537 - (36%)
Similarity:	298/537 - (55%)	Gaps:	16/537 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SYDAENKIWKGIPQNNPFKPETSLGRIIFKNMRNWPKNVCQISDSEGVEVTFGQALTWAIRIAQQ 71
            ::|...|||.|..:.:.|.|:.|:|.|||:.|........|||.:|..|:|:....|.|:::|..
  Fly    16 TFDENLKIWSGGEKRSLFSPDLSIGEIIFQQMERNAMLTAQISVTENTELTWKDIQTNAMKVASY 80

  Fly    72 LKSRGLDHKDIIGISARNTTYIMPTAVACFFHGTPFQSANPILEESTLKHLYNISKPKIIFTDAD 136
            ::..||:..|.:|:..|.||::...|.||||:|||:.:.:...|:|.::.|:.|:||::||.|.|
  Fly    81 MRKLGLEQGDFVGVIGRLTTHLTALAYACFFNGTPYHALHTEYEQSAIERLFGITKPRLIFCDGD 145

  Fly   137 HYDKLYSATSAFKPEIILTTGTKDGVLSIQDLLAPTKTEFFYQPTPLKEGPSQTVAILTSSGTTG 201
            .::|:.:||...:.:|:.......|:|.|||:|. |..|..::|..||:|..|.:|||:||||:|
  Fly   146 EFEKVQAATKGLQVQIVTMRNHPAGILRIQDILT-TPVEMNFRPVRLKDGTDQLLAILSSSGTSG 209

  Fly   202 MPKAVCISN------DILTQETVFVNGYDTIFISASLDWITGLWATIFSTVNGCTRIISSKPFAA 260
            :||||.|||      ..|..::..:.     :...:|||.:|:..||.:.|...|.||....|..
  Fly   210 LPKAVTISNSHQIIGSFLPVDSSIIQ-----YNPNTLDWASGITMTINAAVFSLTSIIEDCDFDP 269

  Fly   261 DYFVYLVSKYSITYALIPPEHCCSLLDCPTATPEKLGSLTKLNFGGGRMTQATVERVKKLAPNGV 325
            .....|:.||.|:...:.......|.:||......|.|:....:||...:.....:::....|..
  Fly   270 ANLCGLIEKYRISMVFVSSSQLAMLSNCPEFYAADLSSVKYFFYGGSNCSLEVQNKIRSRLSNEC 334

  Fly   326 LNSSYGMTEV---GFIVFNHGHLKLTAAGNPLPGIQVKIVDDDGNQLGVNQTGEIIVHNGFSWNG 387
            :|.||.:||:   |.:.||... |..:.|.|:.|||:|||::.|...|.|..|||..:||..|.|
  Fly   335 VNFSYTLTELNSPGCLNFNFDE-KPNSVGRPVRGIQIKIVNELGEAQGPNVVGEICFNNGQKWPG 398

  Fly   388 YFADPEATKAMQDEEGWFHTGDMGYFDEDDYLYMTDRKKEVLKWKGLQMWPAEVEAVIDELPEVK 452
            |:.:||.||.|||.|.||||||:||.|||.||::.||.|::||::.:..:|:|:|:||.|:|.|.
  Fly   399 YYKNPEETKKMQDSENWFHTGDLGYMDEDGYLFIIDRLKDMLKYQTIMYYPSEIESVIAEMPNVV 463

  Fly   453 RVCVIGVYDETQGDVPGALVVREDNATLTAQQVIDHVAKRLPDIQKQLRAGVQFADEIPQNHNGK 517
            ..||.|::|...||...|.||::....|.||.|:::|.||:|...|||..|....|.|.|:.|.|
  Fly   464 EACVFGIWDPVYGDKAAASVVKKQGTQLEAQDVVEYVRKRIPAKFKQLNGGALIVDHIIQSGNRK 528

  Fly   518 VVRRYARDLFVALSKKN 534
            ..|...:..|:.:.:||
  Fly   529 ANRAATKAEFLRIMEKN 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4830	NP_650160.1	CaiC	18..529	CDD:223395	188/519 (36%)
CG4830	NP_650160.1	AFD_class_I	46..518	CDD:302604	177/480 (37%)
CG5568	NP_647992.1	CaiC	35..540	CDD:223395	187/511 (37%)
CG5568	NP_647992.1	Firefly_Luc_like	55..530	CDD:213279	178/481 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471313
Domainoid	1	1.000	215	1.000	Domainoid score	I5876
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26958
OrthoDB	1	1.010	-	-		D24284at7147
OrthoFinder	1	1.000	-	-		FOG0004528
OrthoInspector	1	1.000	-	-		mtm9651
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X778
	10	9.860