DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4830 and Acsm4

DIOPT Version :9

Sequence 1:	NP_650160.1	Gene:	CG4830 / 41477	FlyBaseID:	FBgn0037996	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_859046.1	Gene:	Acsm4 / 353317	RGDID:	727928	Length:	580	Species:	Rattus norvegicus

Alignment Length:	585	Identity:	146/585 - (24%)
Similarity:	225/585 - (38%)	Gaps:	115/585 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 YDAENKIWKGIPQNNPFKPETSLGRIIFKNMRNWPKNVCQISDSEGVEVTFGQALTWAIRIAQQL 72
            ::|.|:..|.:|:|..|..:.         :..|     .:.:..| |.....||.|......::
  Rat    38 FEAINRCEKPLPKNFNFAADV---------LDQW-----SLKEKSG-ERPANPALWWVNGKGDEV 87

  Fly    73 K---------SR----------GLDHKDIIGISARNTTYIMPTA-------VACFFHGTPFQSAN 111
            |         ||          ||...|.:.:       |:|..       |||...|..|....
  Rat    88 KWSFQELGSLSRKAANVLTKPCGLQRGDRVAV-------ILPRIPEWWLINVACMRTGLVFMPGT 145

  Fly   112 PILEESTLKHLYNISKPKIIFTD---ADHYDKLYSATSAFKPEIILTTGTKDGVLSIQDLLAPTK 173
            ..|....:.:....||.|.|...   |...|.:.|.....|.:::::....||.||.|:||....
  Rat   146 IQLTRKDILYRLQASKAKCIVASEEVAPAVDSIASECPNLKTKLLVSPHRWDGWLSFQELLQSAS 210

  Fly   174 TEFFYQPTPLKEGPSQTVAILTSSGTTGMPK-------------AVCISNDI-LTQETVFVNGYD 224
            .|.    ..::.|..:.:||..:|||||.||             |:|....: ||...:..|..|
  Rat   211 EEH----NCVQTGSQEPMAIYFTSGTTGSPKMAQHSQSSLGIGYALCGRYWLDLTSSDIMWNMSD 271

  Fly   225 TIFISASLDWITGLWATIFST-VNG-CTRIISSKPFAADYFVYLVSKYSITYALIPPEHCCSLLD 287
            |       .||.....::||| :.| |..:.....|..|.|:..::.|.||          :|..
  Rat   272 T-------GWIKAAIGSVFSTWLRGACVFVHRMAQFNTDTFLDTLTSYPIT----------TLCS 319

  Fly   288 CPTATPEKL-GSLTKLNF--------GGGRMTQATVERVKKLAPNGV-LNSSYGMTEVGFIVFNH 342
            .||.....: ..|.:..|        ||..:....:|:.|  |..|: |...||.||||.|..|.
  Rat   320 APTVYRMLVQQDLKRYQFKRLRHCLTGGEPLNPEVLEQWK--AQTGLELYEGYGQTEVGIICANR 382

  Fly   343 --GHLKLTAAGNPLPGIQVKIVDDDGNQLGVNQTGEIIVHNGFS-----WNGYFADPEATKAMQD 400
              ..:|..:.|..:....|:|:|:.||.|...:.|||.:..|..     ::.|..:||.|.| ..
  Rat   383 KGEEIKPGSMGKGVVPYDVQIIDEHGNILPSGKEGEIALRLGSDRPFCFFSEYVDNPEKTDA-TI 446

  Fly   401 EEGWFHTGDMGYFDEDDYLYMTDRKKEVLKWKGLQMWPAEVEAVIDELPEVKRVCVIGVYDETQG 465
            ...::.|||.|..|:|.||:...|..:|:...|.::.|.|||:.:.|.|.|....|:...|..:|
  Rat   447 RRNFYITGDRGVMDDDGYLWFVGRADDVIISSGYRIGPFEVESALIEHPAVVESAVVSSPDPIRG 511

  Fly   466 DVPGALVV-----REDNATLTAQQVIDHVAKRLPDIQKQLRAGVQFADEIPQNHNGKVVRRYARD 525
            :|..|.:|     :..|......::.|||.......:...:  |:|..|:|:...||:.|...||
  Rat   512 EVVKAFIVLAAPFKSSNREKLTAELQDHVKNSTAPYKYPRK--VEFVQELPKTITGKIKRNVLRD 574

Fly 526 525
Rat 575 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4830	NP_650160.1	CaiC	18..529	CDD:223395	143/575 (25%)
CG4830	NP_650160.1	AFD_class_I	46..518	CDD:302604	135/538 (25%)
Acsm4	NP_859046.1	MACS_euk	48..577	CDD:341251	143/575 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D683933at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920