DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4830 and DIP2

DIOPT Version :9

Sequence 1:	NP_650160.1	Gene:	CG4830 / 41477	FlyBaseID:	FBgn0037996	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_612019.2	Gene:	DIP2 / 252479	FlyBaseID:	FBgn0024806	Length:	1773	Species:	Drosophila melanogaster

Alignment Length:	706	Identity:	126/706 - (17%)
Similarity:	214/706 - (30%)	Gaps:	263/706 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GIPQNNPFKPETSLGRIIFKNMRNWPKN------VCQISDSEGV---EVTFGQALTWAIRIAQQL 72
            |:.::...||:...|      :..|..|      :..:.:|:|.   .:|..:....|.:||..|
  Fly  1126 GLAEDCERKPQLITG------VLRWRANTSPDHIIFTLLNSKGAIAKTLTCSELHKRAEKIAALL 1184

  Fly    73 KSRGL----DHKDII---GISARNTTYIMPTAVACFFHGTPFQSANPILEE-----------STL 119
            :.||.    ||..:|   |:.           :.|.|:|..:..|.||...           .|:
  Fly  1185 QERGRIEPGDHVALIFPPGLD-----------LLCAFYGCLYLGAIPITIRPPHPQNLNTTLPTV 1238

  Fly   120 KHLYNISKPKIIFT--------------------------DADHYDKLYSA--------TSAFKP 150
            :.:.::||..|:.:                          |.|...|...|        :||:..
  Fly  1239 RMIVDVSKSGIVLSIQPIIKLLKSREAATSIDPKTWPPILDIDDNPKRKYAGIATVSFDSSAYLD 1303

  Fly   151 EIILTTGTKDGV----LSIQDLLAPTK--TEFFYQPTPLKEGPSQTVAILTSSGTTGMPKAVCIS 209
            ..:.|.|...||    .|:..|.|..|  .|.:         ||:.||:...        ..|..
  Fly  1304 FSVSTCGRLSGVNITHRSLSSLCASLKLACELY---------PSRHVALCLD--------PYCGL 1351

  Fly   210 NDILTQETVFVNGYDTIFISA-SLDWITGLWATIFS------------TVNGCTRIISSKPFAAD 261
            ..::.......:|:.:|.|:. .::....||.:..|            .:..||:.:|:.
  Fly  1352 GFVMWTLIGVYSGHHSILIAPYEVEANPSLWLSTLSQHRVRDTFCSYGVIELCTKALSNS----- 1411

  Fly   262 YFVYLVSKYSI------TYALIPPE--------HCCSLLDCPTATPEKLGSLTK---LNFGGGRM 309
              :..:.:.:|      |..::..|        ..|.|.       :.||..|:   .:| |.|:
  Fly  1412 --IPSLKQRNIDLRCVRTCVVVAEERPRVQLTQQFCKLF-------QALGLNTRCVSTSF-GCRV 1466

  Fly   310 TQATVERVKKLAPNGVLNSSYGMTEVGFIVFNHGHLKLTAAGNP-----------LPGIQVKIVD 363
            ..|       :...|..::......|......:..:.|...|.|           |||::|.|.:
  Fly  1467 NPA-------ICVQGASSAESAQVYVDMRALRNNRVALVERGAPNSLCVIESGKLLPGVKVIIAN 1524

  Fly   364 -DDGNQLGVNQTGEIIVHNGFSWNGYFA---------DPEATKAM--QDEEGWFHTGDMGYF--- 413
             :.....|.:..|||.|....:.||||.         |....|.:  ...|.:..||.:|:.
  Fly  1525 PETKGHCGDSHLGEIWVQAPHNANGYFTIYGDETDYNDHFNAKLVTGATSELYARTGYLGFLRRT 1589

  Fly   414 -------------------DED----------------------------------------DYL 419
                               |.|                                        |.:
  Fly  1590 ECSQSASLLDETTPSVASRDSDTESLNSISQLQLNFSNVSLGGNSEHSLVGGASNANDQELHDAV 1654

  Fly   420 YMTDRKKEVLKWKGLQMWPAEVEAVIDELPEVKRVCVIGVYD-------ETQGDVPGALVVREDN 477
            |:.....||:..:|:...|.::|..:....:....|.:..:.       |..|:...||    |.
  Fly  1655 YVVGAVDEVISLRGMNYHPIDIENSVMRCHKKIAECAVFTWTNLLVVVVELDGNESEAL----DL 1715

  Fly   478 ATLTAQQVI-DHVAKRLPDIQKQLRAGVQFADE---IPQNHNGKVVRRYARDLFVA 529
            ..|....|: ||          ||..||....:   :|.|..|:..|.:.||.|:|
  Fly  1716 VPLVTNTVLEDH----------QLIVGVVVVVDPGVVPINSRGEKQRMHLRDGFLA 1761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4830	NP_650160.1	CaiC	18..529	CDD:223395	124/703 (18%)
CG4830	NP_650160.1	AFD_class_I	46..518	CDD:302604	115/658 (17%)
DIP2	NP_612019.2	DMAP_binding	3..115	CDD:283995
		ARG80	33..369	CDD:227400
		PRK09192	470..1061	CDD:236403
		Dip2	470..1054	CDD:213273
		AMP-binding	1142..1587	CDD:278902	91/494 (18%)
		AFD_class_I	1159..1762	CDD:302604	120/667 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900