DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4830 and ACSF3

DIOPT Version :9

Sequence 1:	NP_650160.1	Gene:	CG4830 / 41477	FlyBaseID:	FBgn0037996	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	XP_005256350.1	Gene:	ACSF3 / 197322	HGNCID:	27288	Length:	610	Species:	Homo sapiens

Alignment Length:	536	Identity:	121/536 - (22%)
Similarity:	206/536 - (38%)	Gaps:	117/536 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 ISDSEGVEVTFGQALTWAIRIA----------QQLKSRGL---------------DHKD--IIGI 85
            ::.|:.....|.:||.:..|||          ::|.||.|               |.::  :..:
Human    37 VARSDRSAPVFTRALAFGDRIALVDQHGRHTYRELYSRSLRLSQEICRLCGCVGGDLREERVSFL 101

  Fly    86 SARNTTYIMPTAVACFFHG--TPFQSANPILEESTLKHLYNISKPKIIFTDADHYDKLYSATSAF 148
            .|.:.:|::....:....|  .|....:|..:   |:::...|:..::....::.:.|.......
Human   102 CANDASYVVAQWASWMSGGVAVPLYRKHPAAQ---LEYVICDSQSSVVLASQEYLELLSPVVRKL 163

  Fly   149 -KPEIILTTGTKDGVLSIQDLLAPTKTEFFYQPTPLKEGPSQTVAILTSSGTTGMPKAVCISN-D 211
             .|.:.||.....|.:.     .|.:.     |.|.:...::...|:.:|||||.||.|..:: :
Human   164 GVPLLPLTPAIYTGAVE-----EPAEV-----PVPEQGWRNKGAMIIYTSGTTGRPKGVLSTHQN 218

  Fly   212 ILTQETVFVNGY-----DTIFISASLDWITG--------LW--ATI-----FSTVNGCTRIISSK 256
            |....|..|:.:     |.|.....|..:.|        ||  ||.     ||......:.:||:
Human   219 IRAVVTGLVHKWAWTKDDVILHVLPLHHVHGVVNALLCPLWVGATCVMMPEFSPQQVWEKFLSSE 283

  Fly   257 P-----FAADYFVY--LVSKYSITYALIPPEHCCSLLDCPTATPEKLGSLTKLNFGGGRMTQATV 314
            .     |.|...:|  |:..|...:.   ..|....|  .....||:..:..   |...:....:
Human   284 TPRINVFMAVPTIYTKLMEYYDRHFT---QPHAQDFL--RAVCEEKIRLMVS---GSAALPLPVL 340

  Fly   315 ERVKKLAPNGVLNSSYGMTEVGFIVFNHGHLKLTAA-------GNPLPGIQVKIVDD-------- 364
            |:.|.:..:.:| ..|||||:|..:..    .||.|       |.||||:||:||.:
Human   341 EKWKNITGHTLL-ERYGMTEIGMALSG----PLTTAVRLPGSVGTPLPGVQVRIVSENPQREACS 400

  Fly   365 -----DGNQLGVNQT-------GEIIVHNGFSWNGYFADPEATKAMQDEEGWFHTGDMGYFDEDD 417
                 :|::.|...|       ||::|.....:..|:..||.||:....:|||.|||...|.:..
Human   401 YTIHAEGDERGTKVTPGFEEKEGELLVRGPSVFREYWNKPEETKSAFTLDGWFKTGDTVVFKDGQ 465

  Fly   418 YLYMTDRKKEVLKWKGLQMWPAEVEAVIDELPEVKRVCVIGVYDETQGDVPGALVVREDNATLTA 482
            |........:::|..|.::...|||..:...|.:..|.||||.|.|.|....|:|...:..:|:.
Human   466 YWIRGRTSVDIIKTGGYKVSALEVEWHLLAHPSITDVAVIGVPDMTWGQRVTAVVTLREGHSLSH 530

  Fly   483 QQ------VIDHVAKR 492
            ::      :.:|..||
Human   531 RELKEWARLKEHPTKR 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4830	NP_650160.1	CaiC	18..529	CDD:223395	121/536 (23%)
CG4830	NP_650160.1	AFD_class_I	46..518	CDD:302604	121/536 (23%)
ACSF3	XP_005256350.1	MCS	55..546	CDD:341264	115/516 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.946395	Normalized mean entropy	S3694
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.760